Zobrazeno 1 - 10 of 256 pro vyhledávání: '"Davidson-Smith H"'
1
Akademický článek
DNMT3B PWWP mutations cause hypermethylation of heterochromatin.
Autor: Taglini F; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.; CRUK Edinburgh Centre, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK., Kafetzopoulos I; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.; CRUK Edinburgh Centre, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.; Altos Labs, Cambridge Institute, Cambridge, UK., Rolls W; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.; Wellcome Centre for Cell Biology, University of Edinburgh, Edinburgh, UK., Musialik KI; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.; CRUK Edinburgh Centre, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.; MRC London Institute of Medical Sciences and Institute of Clinical Sciences, Imperial College London, London, UK., Lee HY; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.; CRUK Edinburgh Centre, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.; Endocrine Oncology Research Group, Department of Surgery, The Royal College of Surgeons RCSI, University of Medicine and Health Sciences, Dublin, Ireland., Zhang Y; Wellcome Centre for Cell Biology, University of Edinburgh, Edinburgh, UK., Marenda M; IEO, European Institute of Oncology IRCCS, Department of Experimental Oncology, Milan, Italy., Kerr L; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.; Department of Mathematics and Statistics, University of Strathclyde, Glasgow, UK., Finan H; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.; CRUK Edinburgh Centre, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.; Swiss Federal Institute of Technology, ETH Zürich, Institute of Molecular Health Sciences, Zürich, Switzerland., Rubio-Ramon C; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.; CRUK Edinburgh Centre, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.; Université Paris Cité, CNRS, Institut Jacques Monod, Paris, France., Gautier P; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK., Wapenaar H; Wellcome Centre for Cell Biology, University of Edinburgh, Edinburgh, UK., Kumar D; Wellcome Centre for Cell Biology, University of Edinburgh, Edinburgh, UK., Davidson-Smith H; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK., Wills J; CRUK Edinburgh Centre, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK., Murphy LC; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK., Wheeler A; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK., Wilson MD; Wellcome Centre for Cell Biology, University of Edinburgh, Edinburgh, UK. Marcus.Wilson@ed.ac.uk., Sproul D; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK. d.sproul@ed.ac.uk.; CRUK Edinburgh Centre, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK. d.sproul@ed.ac.uk.
Publikováno v: EMBO reports [EMBO Rep] 2024 Mar; Vol. 25 (3), pp. 1130-1155. Date of Electronic Publication: 2024 Jan 30.
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2
Akademický článek
De novo DNA methyltransferase activity in colorectal cancer is directed towards H3K36me3 marked CpG islands.
Autor: Masalmeh RHA; MRC Human Genetics Unit, IGMM, University of Edinburgh, Edinburgh, UK., Taglini F; MRC Human Genetics Unit, IGMM, University of Edinburgh, Edinburgh, UK.; CRUK Edinburgh Centre, IGMM, University of Edinburgh, Edinburgh, UK., Rubio-Ramon C; MRC Human Genetics Unit, IGMM, University of Edinburgh, Edinburgh, UK.; CRUK Edinburgh Centre, IGMM, University of Edinburgh, Edinburgh, UK., Musialik KI; MRC Human Genetics Unit, IGMM, University of Edinburgh, Edinburgh, UK.; CRUK Edinburgh Centre, IGMM, University of Edinburgh, Edinburgh, UK., Higham J; MRC Human Genetics Unit, IGMM, University of Edinburgh, Edinburgh, UK., Davidson-Smith H; MRC Human Genetics Unit, IGMM, University of Edinburgh, Edinburgh, UK., Kafetzopoulos I; MRC Human Genetics Unit, IGMM, University of Edinburgh, Edinburgh, UK.; CRUK Edinburgh Centre, IGMM, University of Edinburgh, Edinburgh, UK., Pawlicka KP; MRC Human Genetics Unit, IGMM, University of Edinburgh, Edinburgh, UK.; CRUK Edinburgh Centre, IGMM, University of Edinburgh, Edinburgh, UK., Finan HM; MRC Human Genetics Unit, IGMM, University of Edinburgh, Edinburgh, UK.; CRUK Edinburgh Centre, IGMM, University of Edinburgh, Edinburgh, UK., Clark R; Edinburgh Clinical Research Facility, University of Edinburgh, Edinburgh, UK., Wills J; CRUK Edinburgh Centre, IGMM, University of Edinburgh, Edinburgh, UK., Finch AJ; CRUK Edinburgh Centre, IGMM, University of Edinburgh, Edinburgh, UK.; Centre for Tumour Biology, Barts Cancer Institute, Queen Mary University of London, London, UK., Murphy L; Edinburgh Clinical Research Facility, University of Edinburgh, Edinburgh, UK., Sproul D; MRC Human Genetics Unit, IGMM, University of Edinburgh, Edinburgh, UK. Duncan.Sproul@igmm.ed.ac.uk.; CRUK Edinburgh Centre, IGMM, University of Edinburgh, Edinburgh, UK. Duncan.Sproul@igmm.ed.ac.uk.
Publikováno v: Nature communications [Nat Commun] 2021 Jan 29; Vol. 12 (1), pp. 694. Date of Electronic Publication: 2021 Jan 29.
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3
FOXA1 repression is associated with loss of BRCA1 and increased promoter methylation and chromatin silencing in breast cancer
Autor: Gong, C, Fujino, K, Monteiro, LJ, Gomes, AR, Drost, R, Davidson-Smith, H, Takeda, S, Khoo, US, Jonkers, J, Sproul, D, Lam, EW
FOXA1 expression correlates with the breast cancer luminal subtype and patient survival. RNA and protein analysis of a panel of breast cancer cell lines revealed that BRCA1 deficiency is associated with the downregulation of FOXA1 expression. Knockdo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::69e7f88730fd7a60f77c0585a6ba9789
http://hdl.handle.net/10722/214737
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4
Akademický článek
The up-regulation of SYNCRIP promotes the proliferation and tumorigenesis via DNMT3A/p16 in colorectal cancer.
Autor: Li, Chenglong1 (AUTHOR), Lu, Tailiang1 (AUTHOR), Chen, Hongxi1 (AUTHOR), Yu, Zhige1 (AUTHOR) yuzhige1977@sina.com, Chen, Chaowu1 (AUTHOR) dr.chencw@hunnu.edu.cn
Publikováno v: Scientific Reports. 9/16/2024, Vol. 14 Issue 1, p1-14. 14p.
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5
Akademický článek
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6
Akademický článek
DISC1 regulates N-methyl-D-aspartate receptor dynamics: abnormalities induced by a Disc1 mutation modelling a translocation linked to major mental illness.
Autor: Malavasi ELV; Centre for Genomic and Experimental Medicine, MRC Institute of Genetics and Molecular Medicine at the University of Edinburgh, Edinburgh, UK., Economides KD; Xtuit Pharmaceuticals, Waltham, MA, USA., Grünewald E; Centre for Genomic and Experimental Medicine, MRC Institute of Genetics and Molecular Medicine at the University of Edinburgh, Edinburgh, UK., Makedonopoulou P; Centre for Genomic and Experimental Medicine, MRC Institute of Genetics and Molecular Medicine at the University of Edinburgh, Edinburgh, UK., Gautier P; MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine at the University of Edinburgh, Edinburgh, UK., Mackie S; Centre for Genomic and Experimental Medicine, MRC Institute of Genetics and Molecular Medicine at the University of Edinburgh, Edinburgh, UK., Murphy LC; Centre for Genomic and Experimental Medicine, MRC Institute of Genetics and Molecular Medicine at the University of Edinburgh, Edinburgh, UK., Murdoch H; Molecular Pharmacology Group, Wolfson Building, Institute of Neuroscience and Psychology, The University of Glasgow, University Avenue, Glasgow, UK., Crummie D; Centre for Genomic and Experimental Medicine, MRC Institute of Genetics and Molecular Medicine at the University of Edinburgh, Edinburgh, UK., Ogawa F; Centre for Genomic and Experimental Medicine, MRC Institute of Genetics and Molecular Medicine at the University of Edinburgh, Edinburgh, UK., McCartney DL; Centre for Genomic and Experimental Medicine, MRC Institute of Genetics and Molecular Medicine at the University of Edinburgh, Edinburgh, UK., O'Sullivan ST; Centre for Genomic and Experimental Medicine, MRC Institute of Genetics and Molecular Medicine at the University of Edinburgh, Edinburgh, UK., Burr K; Centre for Regenerative Medicine, The University of Edinburgh, Edinburgh, UK., Torrance HS; Centre for Genomic and Experimental Medicine, MRC Institute of Genetics and Molecular Medicine at the University of Edinburgh, Edinburgh, UK., Phillips J; Centre for Genomic and Experimental Medicine, MRC Institute of Genetics and Molecular Medicine at the University of Edinburgh, Edinburgh, UK., Bonneau M; Centre for Genomic and Experimental Medicine, MRC Institute of Genetics and Molecular Medicine at the University of Edinburgh, Edinburgh, UK., Anderson SM; Centre for Genomic and Experimental Medicine, MRC Institute of Genetics and Molecular Medicine at the University of Edinburgh, Edinburgh, UK., Perry P; MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine at the University of Edinburgh, Edinburgh, UK., Pearson M; MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine at the University of Edinburgh, Edinburgh, UK., Constantinides C; Centre for Genomic and Experimental Medicine, MRC Institute of Genetics and Molecular Medicine at the University of Edinburgh, Edinburgh, UK., Davidson-Smith H; Centre for Genomic and Experimental Medicine, MRC Institute of Genetics and Molecular Medicine at the University of Edinburgh, Edinburgh, UK., Kabiri M; Translational In Vivo Models at Sanofi, Frankfurt, Germany., Duff B; Division of Psychiatry, The University of Edinburgh, Edinburgh, UK., Johnstone M; Centre for Genomic and Experimental Medicine, MRC Institute of Genetics and Molecular Medicine at the University of Edinburgh, Edinburgh, UK.; Division of Psychiatry, The University of Edinburgh, Edinburgh, UK., Polites HG; Regeneron Pharmaceuticals, Tarrytown NY, USA., Lawrie SM; Division of Psychiatry, The University of Edinburgh, Edinburgh, UK., Blackwood DH; Division of Psychiatry, The University of Edinburgh, Edinburgh, UK., Semple CA; MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine at the University of Edinburgh, Edinburgh, UK., Evans KL; Centre for Genomic and Experimental Medicine, MRC Institute of Genetics and Molecular Medicine at the University of Edinburgh, Edinburgh, UK., Didier M; Translational Sciences at Sanofi, Chilly-Mazarin, France., Chandran S; Centre for Regenerative Medicine, The University of Edinburgh, Edinburgh, UK., McIntosh AM; Division of Psychiatry, The University of Edinburgh, Edinburgh, UK., Price DJ; Centre for Integrative Physiology, The University of Edinburgh, Edinburgh, UK., Houslay MD; School of Cancer and Pharmaceutical Sciences, King's College London, London, UK., Porteous DJ; Centre for Genomic and Experimental Medicine, MRC Institute of Genetics and Molecular Medicine at the University of Edinburgh, Edinburgh, UK., Millar JK; Centre for Genomic and Experimental Medicine, MRC Institute of Genetics and Molecular Medicine at the University of Edinburgh, Edinburgh, UK. kirsty.millar@igmm.ed.ac.uk.
Publikováno v: Translational psychiatry [Transl Psychiatry] 2018 Sep 06; Vol. 8 (1), pp. 184. Date of Electronic Publication: 2018 Sep 06.
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7
Akademický článek
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9
Akademický článek
Epigenetic Landscape and Therapeutic Implication of Gene Isoforms of Doublecortin-Like Kinase 1 for Cancer Stem Cells.
Autor: Moore, Landon L.1 (AUTHOR) landon-moore@ouhsc.edu, Houchen, Courtney W.1,2,3 (AUTHOR) courtney-houchen@ouhsc.edu
Publikováno v: International Journal of Molecular Sciences. Nov2023, Vol. 24 Issue 22, p16407. 17p.
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10
Akademický článek
Genome-wide single-molecule analysis of long-read DNA methylation reveals heterogeneous patterns at heterochromatin that reflect nucleosome organisation.
Autor: Kerr, Lyndsay1 (AUTHOR), Kafetzopoulos, Ioannis2,3 (AUTHOR), Grima, Ramon4 (AUTHOR), Sproul, Duncan2 (AUTHOR) d.sproul@ed.ac.uk
Publikováno v: PLoS Genetics. 10/2/2023, Vol. 19 Issue 10, p1-32. 32p.
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