Zobrazeno 1 - 10 of 10 pro vyhledávání: '"Davidson Zhao"'
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Akademický článek
Molecular characterization of AML‐MRC reveals TP53 mutation as an adverse prognostic factor irrespective of MRC‐defining criteria, TP53 allelic state, or TP53 variant allele frequency
Autor: Davidson Zhao, Entsar Eladl, Mojgan Zarif, José‐Mario Capo‐Chichi, Andre Schuh, Eshetu Atenafu, Mark Minden, Hong Chang
Publikováno v: Cancer Medicine, Vol 12, Iss 6, Pp 6511-6522 (2023)
Abstract Background Acute myeloid leukemia with myelodysplasia‐related changes (AML‐MRC) generally confers poor prognosis, however, patient outcomes are heterogeneous. The impact of TP53 allelic state and variant allele frequency (VAF) in AML‐M
Externí odkaz: https://doaj.org/article/6f54f92f63484ca5b7485ba8f700b7ea
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3
TP53 Mutations in AML Patients Are Associated with Dismal Clinical Outcome Irrespective of Frontline Induction Regimen and Allogeneic Hematopoietic Cell Transplantation
Autor: Chang, Davidson Zhao, Mojgan Zarif, Qianghua Zhou, José-Mario Capo-Chichi, Andre Schuh, Mark D. Minden, Eshetu G. Atenafu, Rajat Kumar, Hong
Publikováno v: Cancers; Volume 15; Issue 12; Pages: 3210
TP53 mutations are associated with extremely poor outcomes in acute myeloid leukemia (AML). The outcomes of patients with TP53-mutated (TP53MUT) AML after different frontline treatment modalities are not well established. Allogeneic hematopoietic cel
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=multidiscipl::082d7acd1fa7e8152118d670185532e3
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5
Molecular genetic characterization of Philadelphia chromosome-positive acute myeloid leukemia
Autor: Qianghua Zhou, Davidson Zhao, Entsar Eladl, Jose-Mario Capo-Chichi, Dennis Dong Hwan Kim, Hong Chang
Publikováno v: Leukemia research. 124
Philadelphia chromosome-positive acute myeloid leukemia (Ph+ AML) is a provisional disease entity in the 2016 WHO classification, while its genetic profile of Ph+ AML remains poorly defined. In addition, the differentiating features of Ph+ AML and ch
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c52b8418d70589715ccad414def6addd
https://pubmed.ncbi.nlm.nih.gov/36563650
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6
Molecular characterization of AML-MRC reveals TP53 mutation as an adverse prognostic factor irrespective of MRC-defining criteria, TP53 allelic state, or TP53 variant allele frequency
Autor: Davidson, Zhao, Entsar, Eladl, Mojgan, Zarif, José-Mario, Capo-Chichi, Andre, Schuh, Eshetu, Atenafu, Mark, Minden, Hong, Chang
Publikováno v: Cancer medicineREFERENCES.
Acute myeloid leukemia with myelodysplasia-related changes (AML-MRC) generally confers poor prognosis, however, patient outcomes are heterogeneous. The impact of TP53 allelic state and variant allele frequency (VAF) in AML-MRC remains poorly defined.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::73ea409b20108f29a7a80ca4722d804a
https://pubmed.ncbi.nlm.nih.gov/36394085
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8
Targeting an MDM2/MYC Axis to Overcome Drug Resistance in Multiple Myeloma
Autor: Omar Faruq, Davidson Zhao, Mariusz Shrestha, Andrea Vecchione, Eldad Zacksenhaus, Hong Chang
Publikováno v: Cancers; Volume 14; Issue 6; Pages: 1592
Background: MDM2 is elevated in multiple myeloma (MM). Although traditionally, MDM2 negatively regulates p53, a growing body of research suggests that MDM2 plays several p53-independent roles in cancer pathogenesis as a regulator of oncogene mRNA sta
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2a586dd55e8fd3a682ad655f7d0c8a7
https://pubmed.ncbi.nlm.nih.gov/35326742
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9
NPM1-mutated AML-MRC diagnosed on the basis of history of MDS or MDS/MPN frequently harbours secondary-type mutations and confers inferior outcome compared to AML with mutated NPM1
Autor: Davidson Zhao, Mojgan Zarif, Entsar Eladl, José-Mario Capo-Chichi, Adam C. Smith, Eshetu G. Atenafu, Anne Tierens, Mark D. Minden, Andre Schuh, Hong Chang
Publikováno v: Leukemia Research. 118:106869
Acute myeloid leukemia with myelodysplasia-related changes (AML-MRC) is a prognostically diverse disease. Owing to its favourable prognosis, AML-MRC with mutated NPM1 (NPM1The clinicopathological features, molecular profiles and outcomes of 241 AML-M
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39745b21aea71b1beaee2cad22d6e7e1
https://doi.org/10.1016/j.leukres.2022.106869
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Downregulation of MDM2 Leads to Anti-Proliferative Effects through Activation of p53-Associated Pathway Mediated By Both Dual Inhibitor MX69 and Mir-548c-3p in Multiple Myeloma
Autor: Min Zhang, Davidson Zhao, Jian Wu, Hong Chang, Faruq Faruq, Jonahunnatha Nesson George William
Publikováno v: Blood. 134:4419-4419
Multiple myeloma (MM) is a plasma cell malignancy characterized by abnormal proliferation of clonal plasma cells in the bone marrow. MM remains an incurable disease with a high rate of relapse and development of drug resistance. Mouse double minute 2
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8c7c69cf9a405753a53a22ff994d630c
https://doi.org/10.1182/blood-2019-129430
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