Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Davide Pradella"'
Autor:
Davide Pradella, Gianluca Deflorian, Alex Pezzotta, Anna Di Matteo, Elisa Belloni, Daniele Campolungo, Andrea Paradisi, Mattia Bugatti, William Vermi, Matteo Campioni, Antonella Chiapparino, Luigi Scietti, Federico Forneris, Costanza Giampietro, Nina Volf, Michael Rehman, Serena Zacchigna, Maria Paola Paronetto, Anna Pistocchi, Anne Eichmann, Patrick Mehlen, Claudia Ghigna
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
UNC5B is a Netrin-1 receptor expressed in endothelial cells that in the absence of ligand induces apoptosis. Here the authors identify an UNC5B splicing isoform that is insensitive to the pro-survival ligand Netrin-1 and is required for apoptosis-dep
Externí odkaz:
https://doaj.org/article/bc552c64149c47869cf73be5501499a0
Autor:
Anna Di Matteo, Elisa Belloni, Davide Pradella, Anna Maria Chiaravalli, Giacomo Maria Pini, Mattia Bugatti, Roberta Alfieri, Chiara Barzan, Elena Franganillo Tena, Silvia Bione, Elisa Terenzani, Fausto Sessa, Christopher D. R. Wyatt, William Vermi, Claudia Ghigna
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 9, p 8102 (2023)
Angiogenesis is crucial for cancer progression. While several anti-angiogenic drugs are in use for cancer treatment, their clinical benefits are unsatisfactory. Thus, a deeper understanding of the mechanisms sustaining cancer vessel growth is fundame
Externí odkaz:
https://doaj.org/article/5533e10b06cc462aaeccf54295a027ba
Autor:
Anna Di Matteo, Elisa Belloni, Davide Pradella, Ambra Cappelletto, Nina Volf, Serena Zacchigna, Claudia Ghigna
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 39, Iss 1, Pp 1-19 (2020)
Abstract Alternative splicing (AS) is a pervasive molecular process generating multiple protein isoforms, from a single gene. It plays fundamental roles during development, differentiation and maintenance of tissue homeostasis, while aberrant AS is c
Externí odkaz:
https://doaj.org/article/ff0b01acf4e14a90b143c5b7c6634b64
Autor:
Jagyeong Oh, Davide Pradella, Yoonseong Kim, Changwei Shao, Hairi Li, Namjeong Choi, Jiyeon Ha, Anna Di Matteo, Xiang-Dong Fu, Xuexiu Zheng, Claudia Ghigna, Haihong Shen
Publikováno v:
Cancers, Vol 13, Iss 12, p 3071 (2021)
Breast cancer is the most frequently occurred cancer type and the second cause of death in women worldwide. Alternative splicing (AS) is the process that generates more than one mRNA isoform from a single gene, and it plays a major role in expanding
Externí odkaz:
https://doaj.org/article/88a4e3cc70314e67b20dcd3d01a130bd
Autor:
Francesca Angiolini, Elisa Belloni, Marco Giordano, Matteo Campioni, Federico Forneris, Maria Paola Paronetto, Michela Lupia, Chiara Brandas, Davide Pradella, Anna Di Matteo, Costanza Giampietro, Giovanna Jodice, Chiara Luise, Giovanni Bertalot, Stefano Freddi, Matteo Malinverno, Manuel Irimia, Jon D Moulton, James Summerton, Antonella Chiapparino, Carmen Ghilardi, Raffaella Giavazzi, Daniel Nyqvist, Davide Gabellini, Elisabetta Dejana, Ugo Cavallaro, Claudia Ghigna
Publikováno v:
eLife, Vol 8 (2019)
The biological players involved in angiogenesis are only partially defined. Here, we report that endothelial cells (ECs) express a novel isoform of the cell-surface adhesion molecule L1CAM, termed L1-ΔTM. The splicing factor NOVA2, which binds direc
Externí odkaz:
https://doaj.org/article/376dd173fafe4dde820cc904b3e48e1d
Autor:
Jagyeong Oh, Davide Pradella, Changwei Shao, Hairi Li, Namjeong Choi, Jiyeon Ha, Sonia Ruggiero, Xiang-Dong Fu, Xuexiu Zheng, Claudia Ghigna, Haihong Shen
Publikováno v:
Cells, Vol 10, Iss 4, p 858 (2021)
Aberrant alternative splicing (AS) is a hallmark of cancer and a potential target for novel anti-cancer therapeutics. Breast cancer-associated AS events are known to be linked to disease progression, metastasis, and survival of breast cancer patients
Externí odkaz:
https://doaj.org/article/0e25bcbfa710456fafb43b35e31eb1ef
Autor:
Jiyeon Ha, Hana Jang, Namjeong Choi, Jagyeong Oh, Chanhyuk Min, Davide Pradella, Da-Woon Jung, Darren R. Williams, Daeho Park, Claudia Ghigna, Xuexiu Zheng, Haihong Shen
Publikováno v:
Cells, Vol 10, Iss 3, p 679 (2021)
Alternative splicing (AS) is an important posttranscriptional regulatory process. Damaged or unnecessary cells need to be removed though apoptosis to maintain physiological processes. Caspase-2 pre-mRNA produces pro-apoptotic long mRNA and anti-apopt
Externí odkaz:
https://doaj.org/article/6042f6f5d8524550a785883f7e51c77b
Autor:
Jagyeong Oh, Yongchao Liu, Namjeong Choi, Jiyeon Ha, Davide Pradella, Claudia Ghigna, Xuexiu Zheng, Haihong Shen
Publikováno v:
Cancers, Vol 12, Iss 11, p 3195 (2020)
CD44 is a transmembrane glycoprotein involved in cell–cell and cell–matrix interactions. Several CD44 protein isoforms are generated in human through alternative splicing regulation of nine variable exons encoding for the extracellular juxta-memb
Externí odkaz:
https://doaj.org/article/bce0ad7b802b47ff9d839dd223d68b37
Autor:
Alex Pezzotta, Anna Pistocchi, Patrick Mehlen, Andrea Paradisi, Anna Di Matteo, Federico Forneris, Daniele Campolungo, Costanza Giampietro, Elisa Belloni, Gianluca Deflorian, Nina Volf, Antonella Chiapparino, Michael Rehman, William Vermi, Maria Paola Paronetto, Mattia Bugatti, Davide Pradella, Claudia Ghigna, Anne Eichmann, Matteo Campioni, Serena Zacchigna, Luigi Scietti
Publikováno v:
Nature Communications
Nature Communications, 2021, 12 (1), pp.4872. ⟨10.1038/s41467-021-24998-6⟩
Nature Communications, 12
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Nature Communications, Nature Publishing Group, 2021, 12 (1), pp.4872. ⟨10.1038/s41467-021-24998-6⟩
Nature Communications, 2021, 12 (1), pp.4872. ⟨10.1038/s41467-021-24998-6⟩
Nature Communications, 12
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Nature Communications, Nature Publishing Group, 2021, 12 (1), pp.4872. ⟨10.1038/s41467-021-24998-6⟩
The Netrin-1 receptor UNC5B is an axon guidance regulator that is also expressed in endothelial cells (ECs), where it finely controls developmental and tumor angiogenesis. In the absence of Netrin-1, UNC5B induces apoptosis that is blocked upon Netri
Autor:
Claudia Ghigna, Hairi Li, Namjeong Choi, Xuexiu Zheng, Jiyeon Ha, Haihong Shen, Yoonseong Kim, Changwei Shao, Jagyeong Oh, Xiang-Dong Fu, Davide Pradella, Anna Di Matteo
Publikováno v:
Cancers
Volume 13
Issue 12
Cancers, Vol 13, Iss 3071, p 3071 (2021)
Cancers, vol 13, iss 12
Volume 13
Issue 12
Cancers, Vol 13, Iss 3071, p 3071 (2021)
Cancers, vol 13, iss 12
Simple Summary Aberrant alternative splicing (AS) regulation plays a pivotal role in breast cancer development, progression, and resistance to therapeutical interventions. Indeed, cancer cells can adapt their own transcriptome by changing different A