Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Davide Moiani"'
Autor:
Davide Moiani, John A. Tainer
Publikováno v:
Frontiers in Molecular Biosciences, Vol 11 (2024)
While many researchers can design knockdown and knockout methodologies to remove a gene product, this is mainly untrue for new chemical inhibitor designs that empower multifunctional DNA Damage Response (DDR) networks. Here, we present a robust Goldi
Externí odkaz:
https://doaj.org/article/632138a147ec4d4d8690bbfa253a66fc
Autor:
Jerry H. Houl, Zu Ye, Chris A. Brosey, Lakshitha P. F. Balapiti-Modarage, Sarita Namjoshi, Albino Bacolla, Daniel Laverty, Brian L. Walker, Yasin Pourfarjam, Leslie S. Warden, Naga Babu Chinnam, Davide Moiani, Roderick A. Stegeman, Mei-Kuang Chen, Mien-Chie Hung, Zachary D. Nagel, Tom Ellenberger, In-Kwon Kim, Darin E. Jones, Zamal Ahmed, John A. Tainer
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
PARG catalyzes the removal of poly(ADP-ribose) (PAR) from target proteins and executes critical functions in the DNA damage response. Here the authors provide structural and biological insight with small molecule PARG inhibitors and show that PARG in
Externí odkaz:
https://doaj.org/article/b8239efdcde244de83ae43188c91b2d3
Autor:
Dihua Yu, John A. Tainer, Jenny C. Chang, Shao-Cong Sun, Haoqiang Ying, Wen-Ling Kuo, Xianghua Liu, Yohei Saito, Akosua Badu-Nkansah, Chenyu Zhang, Ping Li, Arseniy E. Yuzhalin, Lin Zhang, Hongzhong Li, Jun Yao, Davide Moiani, Zamal Ahmed, Yuan Zhang, Yutao Qi, Kai Sun, Yi Xiao, Yimin Duan, Xiangliang Yuan
Supplementary Data from Vitamin E Enhances Cancer Immunotherapy by Reinvigorating Dendritic Cells via Targeting Checkpoint SHP1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::154bc5981696651ae8cde6a89bc4e522
https://doi.org/10.1158/2159-8290.22541254
https://doi.org/10.1158/2159-8290.22541254
Autor:
Dihua Yu, John A. Tainer, Jenny C. Chang, Shao-Cong Sun, Haoqiang Ying, Wen-Ling Kuo, Xianghua Liu, Yohei Saito, Akosua Badu-Nkansah, Chenyu Zhang, Ping Li, Arseniy E. Yuzhalin, Lin Zhang, Hongzhong Li, Jun Yao, Davide Moiani, Zamal Ahmed, Yuan Zhang, Yutao Qi, Kai Sun, Yi Xiao, Yimin Duan, Xiangliang Yuan
Despite the popular use of dietary supplements during conventional cancer treatments, their impacts on the efficacies of prevalent immunotherapies, including immune-checkpoint therapy (ICT), are unknown. Surprisingly, our analyses of electronic healt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbadfae3bf1ca3b84fe40c1ef2c54ec8
https://doi.org/10.1158/2159-8290.c.6549589.v1
https://doi.org/10.1158/2159-8290.c.6549589.v1
Autor:
Xiangliang Yuan, Yimin Duan, Yi Xiao, Kai Sun, Yutao Qi, Yuan Zhang, Zamal Ahmed, Davide Moiani, Jun Yao, Hongzhong Li, Lin Zhang, Arseniy E. Yuzhalin, Ping Li, Chenyu Zhang, Akosua Badu-Nkansah, Yohei Saito, Xianghua Liu, Wen-Ling Kuo, Haoqiang Ying, Shao-Cong Sun, Jenny C. Chang, John A. Tainer, Dihua Yu
Publikováno v:
Cancer Discov
Despite the popular use of dietary supplements during conventional cancer treatments, their impacts on the efficacies of prevalent immunotherapies, including immune-checkpoint therapy (ICT), are unknown. Surprisingly, our analyses of electronic healt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5985879b0d56272b3b7831d3f94d5c50
https://doi.org/10.1158/2159-8290.cd-21-0900
https://doi.org/10.1158/2159-8290.cd-21-0900
Autor:
Chris A. Brosey, Runze Shen, Davide Moiani, Darin E. Jones, Kathryn Burnett, Greg L. Hura, John A. Tainer
Publikováno v:
Small Angle Scattering Part B: Methods for Structural Interpretation ISBN: 9780323991810
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9751060d4c2ee5d3eaaa6f6b8e32282b
https://doi.org/10.1016/bs.mie.2022.09.022
https://doi.org/10.1016/bs.mie.2022.09.022
Autor:
John A. Tainer, Darin E. Jones, Yan Yan, Davide Moiani, John J. Pink, Stanton L. Gerson, Daniel J. Laverty, Sarita Namjoshi, Dave S. Shin, Yuriy Fedorov, Zamal Ahmed, My T. Nguyen, Andrew S. Arvai, Zachary D. Nagel, Edward J. Selvik
Publikováno v:
Progress in biophysics and molecular biology
Human uracil DNA-glycosylase (UDG) is the prototypic and first identified DNA glycosylase with a vital role in removing deaminated cytosine and incorporated uracil and 5-fluorouracil (5-FU) from DNA. UDG depletion sensitizes cells to high APOBEC3B de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b56ffc793d58107fe40a464f176770b
https://doi.org/10.1016/j.pbiomolbio.2021.02.004
https://doi.org/10.1016/j.pbiomolbio.2021.02.004
Autor:
Ka Cheong Lee, Kay Padget, Hannah Curtis, Ian G. Cowell, Davide Moiani, Zbyslaw Sondka, Nicholas J. Morris, Graham H. Jackson, Simon J. Cockell, John A. Tainer, Caroline A. Austin
Publikováno v:
Biology Open, Vol 1, Iss 9, Pp 863-873 (2012)
Summary Topoisomerase II creates a double-strand break intermediate with topoisomerase covalently coupled to the DNA via a 5′-phosphotyrosyl bond. These intermediate complexes can become cytotoxic protein-DNA adducts and DSB repair at these lesions
Externí odkaz:
https://doaj.org/article/c1789a07de1448d3ab9e218b1af5e122
Autor:
Davide, Moiani, Todd M, Link, Chris A, Brosey, Panagiotis, Katsonis, Olivier, Lichtarge, Youngchang, Kim, Andrzej, Joachimiak, Zhijun, Ma, In-Kwon, Kim, Zamal, Ahmed, Darin E, Jones, Susan E, Tsutakawa, John A, Tainer
Publikováno v:
Methods in Enzymology
We present a Chemistry and Structure Screen Integrated Efficiently (CASSIE) approach (named for Greek prophet Cassandra) to design inhibitors for cancer biology and pathogenesis. CASSIE provides an effective path to target master keys to control the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::ca218418abb5cfe9bec3ed739a35e092
http://europepmc.org/articles/PMC8474023
http://europepmc.org/articles/PMC8474023
Autor:
John A. Tainer, Davide Moiani, Ashley M. Deacon, Millie M. Georgiadis, Matthew A. J. Duncton, Andrew P. Yeh, Patricia Pellicena, Andrew S. Arvai, David M. Wilson, Debanu Das
Publikováno v:
Progress in biophysics and molecular biology
Cancer will directly affect the lives of over one-third of the population. The DNA Damage Response (DDR) is an intricate system involving damage recognition, cell cycle regulation, DNA repair, and ultimately cell fate determination, playing a central
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2907db155d8a91d57edcb2e66d86b79e
https://escholarship.org/uc/item/00q4j9tj
https://escholarship.org/uc/item/00q4j9tj