Zobrazeno 1 - 10
of 138
pro vyhledávání: '"Davide Michieletto"'
Publikováno v:
Physical Review Research, Vol 6, Iss 3, p 033160 (2024)
Loop extrusion is one of the main processes shaping chromosome organization across the cell cycle, yet its role in regulating deoxyribonucleic acid (DNA) entanglement and nucleoplasm viscoelasticity remains overlooked. We simulate entangled solutions
Externí odkaz:
https://doaj.org/article/5a929eabc0ca4b44ae316062be7b8623
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Phase separation has been suggested as a mechanism for heterochromatin formation through condensation of heterochromatin-associated factors. Here the authors show Polycomb complex PRC1 forms condensates on chromatin. Using optogenetic tools they nucl
Externí odkaz:
https://doaj.org/article/7f452b896dc54166b408650ee691f243
Publikováno v:
Physical Review X, Vol 13, Iss 2, p 021010 (2023)
Kinetoplast DNA (kDNA) is a two-dimensional Olympic-ring-like network of mutually linked DNA minicircles found in certain parasites called trypanosomes. Understanding the self-assembly and replication of this structure are not only major open questio
Externí odkaz:
https://doaj.org/article/1b0c945aa2c34735b17c81121d51d81a
Publikováno v:
Mobile DNA, Vol 11, Iss 1, Pp 1-10 (2020)
Abstract Chromosome organisation is increasingly recognised as an essential component of genome regulation, cell fate and cell health. Within the realm of transposable elements (TEs) however, the spatial information of how genomes are folded is still
Externí odkaz:
https://doaj.org/article/427e9980a5504e28bb4a00096cf60322
Publikováno v:
Royal Society Open Science, Vol 7, Iss 11 (2020)
The study and the investigation of structural and dynamical properties of complex systems have attracted considerable interest among scientists in general and physicists and biologists in particular. The present review paper represents a broad overvi
Externí odkaz:
https://doaj.org/article/bb7ae5bfd600454697840549ee9f9e18
Publikováno v:
Physical Review Research, Vol 3, Iss 4, p 043070 (2021)
Topological entanglements are abundant, and often detrimental, in polymeric systems in biology and materials science. Here we theoretically investigate the topological simplification of knots by diffusing slip-links (SLs), which may represent biologi
Externí odkaz:
https://doaj.org/article/0474545bd60943e7a5cf238b468d57bc
Autor:
Davide Michieletto, Mattia Marenda
Publikováno v:
Michieletto, D & Marenda, M 2022, ' Rheology and Viscoelasticity of Proteins and Nucleic Acids Condensates ', JACS Au, vol. 2, no. 7, pp. 1506-1521 . https://doi.org/10.1021/jacsau.2c00055
Phase separation is as familiar as watching vinegar separating from oil in vinegrette. The observation that phase separation of proteins and nucleic acids is widespread in living cells has opened an entire field of research into the biological signif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30eb4f7947befd2af463fff048594b77
https://doi.org/10.1021/jacsau.2c00055
https://doi.org/10.1021/jacsau.2c00055
Autor:
Michael Chiang, Davide Michieletto, Chris A. Brackley, Nattaphong Rattanavirotkul, Hisham Mohammed, Davide Marenduzzo, Tamir Chandra
Publikováno v:
Cell Reports, Vol 28, Iss 12, Pp 3212-3223.e6 (2019)
Summary: Lamina-associated domains (LADs) cover a large part of the human genome and are thought to play a major role in shaping the nuclear architectural landscape. Here, we perform polymer simulations, microscopy, and mass spectrometry to dissect t
Externí odkaz:
https://doaj.org/article/b3bd1b48ebd04c8aab0d737c668e05f9
Autor:
Davide Michieletto
Publikováno v:
Physics World. 34:48-52
DNA molecules are not fixed objects – they are constantly getting broken up and glued back together to adopt new shapes. Davide Michieletto explains how this process can be harnessed to create a new generation of “topologically active” material
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9570b2e81e8ed6c2f5884343bd96dea1
https://doi.org/10.1088/2058-7058/34/03/33
https://doi.org/10.1088/2058-7058/34/03/33
Autor:
Davide Michieletto
Publikováno v:
Entropy, Vol 22, Iss 10, p 1130 (2020)
Systems of “living” polymers are ubiquitous in industry and are traditionally realised using surfactants. Here I first review the theoretical state-of-the-art of living polymers and then discuss non-equilibrium extensions that may be realised wit
Externí odkaz:
https://doaj.org/article/ace9246352684b649e8dd723b2e36598