Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Davide Mercadante"'
Autor:
Bikash Chandra Swain, Pascale Sarkis, Vanessa Ung, Sabrina Rousseau, Laurent Fernandez, Ani Meltonyan, V. Esperance Aho, Davide Mercadante, Cameron D. Mackereth, Mikayel Aznauryan
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract Eukaryotic translation initiation factor eIF4B is required for efficient cap-dependent translation, it is overexpressed in cancer cells, and may influence stress granule formation. Due to the high degree of intrinsic disorder, eIF4B is rarel
Externí odkaz:
https://doaj.org/article/faf2eb2ccf9f4538a76de5ae612d6eb5
Autor:
Sveinn Bjarnason, Jordan A. P. McIvor, Andreas Prestel, Kinga S. Demény, Jakob T. Bullerjahn, Birthe B. Kragelund, Davide Mercadante, Pétur O. Heidarsson
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract More than 1600 human transcription factors orchestrate the transcriptional machinery to control gene expression and cell fate. Their function is conveyed through intrinsically disordered regions (IDRs) containing activation or repression dom
Externí odkaz:
https://doaj.org/article/cf925b9e5d8d4791bf5953ea7b946d44
Autor:
Christopher Zapp, Agnieszka Obarska-Kosinska, Benedikt Rennekamp, Markus Kurth, David M. Hudson, Davide Mercadante, Uladzimir Barayeu, Tobias P. Dick, Vasyl Denysenkov, Thomas Prisner, Marina Bennati, Csaba Daday, Reinhard Kappl, Frauke Gräter
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-8 (2020)
The existence, nature and biological relevance of mechanoradicals in proteins are unknown. Here authors show that mechanical stress on collagen produces radicals and subsequently reactive oxygen species and suggest that collagen I evolved as a radica
Externí odkaz:
https://doaj.org/article/50b8db94c94742b2bea4990163c8a11d
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
Externí odkaz:
https://doaj.org/article/3183f4b9d0824a7588b87b6a233bab52
Publikováno v:
eLife, Vol 10 (2021)
The Parkinson’s disease protein α-synuclein (αSyn) promotes membrane fusion and fission by interacting with various negatively charged phospholipids. Despite postulated roles in endocytosis and exocytosis, plasma membrane (PM) interactions of αS
Externí odkaz:
https://doaj.org/article/6639fa7bd134425bb132e8bc8c89d928
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
How intrinsically disordered proteins (IDPs) undergo a coupled folding and binding reaction with their molecular targets remains to be understood. Here authors use single-molecule FRET to assess the contribution of cis/trans isomerization of peptidyl
Externí odkaz:
https://doaj.org/article/0300d09d545747a38524b19feaddaff8
Autor:
Piau Siong Tan, Iker Valle Aramburu, Davide Mercadante, Swati Tyagi, Aritra Chowdhury, Daniel Spitz, Sarah L. Shammas, Frauke Gräter, Edward A. Lemke
Publikováno v:
Cell Reports, Vol 22, Iss 13, Pp 3660-3671 (2018)
Summary: Phenylalanine-glycine-rich nucleoporins (FG-Nups) are intrinsically disordered proteins, constituting the selective barrier of the nuclear pore complex (NPC). Previous studies showed that nuclear transport receptors (NTRs) were found to inte
Externí odkaz:
https://doaj.org/article/380e982b92924a18a55fbbab5cd803e3
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e87581 (2014)
Pectin methylesterases (PMEs) hydrolyze the methylester groups that are found on the homogalacturonan (HG) chains of pectic polysaccharides in the plant cell wall. Plant and bacterial PMEs are especially interesting as the resulting de-methylesterifi
Externí odkaz:
https://doaj.org/article/1a8e8ea8b1c0450ab61881ed31e91f79
Publikováno v:
Biophysical Journal. 121:684-691
Cellular mechanosensing is pivotal for virtually all biological processes, and many molecular mechano-sensors and their way of function are being uncovered. In this work, we suggest that c-Src kinase acts as a direct mechano-sensor. c-Src is responsi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9975927520bc05059f8a80c95d58b2a8
https://doi.org/10.1016/j.bpj.2022.01.028
https://doi.org/10.1016/j.bpj.2022.01.028
Autor:
Josip Safran, Vanessa Ung, Julie Bouckaert, Olivier Habrylo, Roland Molinié, Jean-Xavier Fontaine, Adrien Lemaire, Aline Voxeur, Serge Pilard, Corinne Pau-Roblot, Davide Mercadante, Jérôme Pelloux, Fabien Sénéchal
Pectins, complex polysaccharides and major components of the plant primary cell wall, can be degraded by pectate lyases (PLs). PLs cleave glycosidic bonds of homogalacturonans (HG), the main pectic domain, by β-elimination, releasing unsaturated oli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee829c028e9813156607bfca52b6bece
https://hal.science/hal-03858972
https://hal.science/hal-03858972
