Výsledky vyhledávání - "Davide Lazzereschi"

Efficient production by sperm-mediated gene transfer of human decay accelerating factor (hDAF) transgenic pigs for xenotransplantation

Publikováno v: Proceedings of the National Academy of Sciences. 99:14230-14235

A large number ofhDAFtransgenic pigs to be used for xenotransplantation research were generated by using sperm-mediated gene transfer (SMGT). The efficiency of transgenesis obtained with SMGT was much greater than with any other method. In the experi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7aa64fa36bc72d919722ab8af97a8fa0
https://doi.org/10.1073/pnas.222550299

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Microsatellite instability in thyroid tumours and tumour-like lesions

Autor: Alessandro Cama, M C Verì, Francesco Nardi, G Colletta, Raffaele Palmirotta, Renato Mariani-Costantini, Annalisa Ranieri, Davide Lazzereschi, Laura Ottini, Francesco Cetta

Publikováno v: British Journal of Cancer

Fifty-one thyroid tumours and tumour-like lesions were analysed for instability at ten dinucleotide microsatellite loci and at two coding mononucleotide repeats within the transforming growth factor β (TGF-β) type II receptor (TβRII) and insulin-l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d87d5b750a0e3589f38f242e0203f21
http://europepmc.org/articles/PMC2362211

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Cyclin D1 and cyclin E expression in malignant thyroid cells and in human thyroid carcinomas

Autor: Francesco Nardi, Giulia Colletta, Caterina Carnovale Scalzo, Laura Sambuco, Annalisa Ranieri, Davide Lazzereschi, Gabriella Mincione

Publikováno v: International Journal of Cancer. 76:806-811

Evidence of the involvement of cyclin gene alterations in human cancer is growing. In this study, we sought to determine the pattern of expression of cyclin D1 and cyclin E in normal and malignant thyroid cells. Quiescent rat thyroid cells in culture

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9140fc22c6e6ba2ccdbff123760dc59e
https://doi.org/10.1002/(sici)1097-0215(19980610)76:6<806::aid-ijc7>3.0.co

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Restored expression of transforming growth factor β type II receptor ink-ras-transformed thyroid cells, TGFβ-resistant, reverts their malignant phenotype

Autor: Susanna Scarpa, Giulia Colletta, Annalisa Ranieri, Davide Lazzereschi, Maria Ragano-Caracciolo, Barbara Lucignano, Gabriella Mincione, Alessandra Turco, Anna Coppa

Publikováno v: Journal of Cellular Physiology. 172:200-208

Transforming growth factor beta 1 (TGF beta 1) inhibits the growth of normal rat epithelial thyroid cells (FRTL-5 strain) by counteracting thyrotropin (TSH)-stimulated DNA synthesis and by slowing the cells in the G1 phase of the cell cycle. Here, we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::61725beb3cc82f570f5e76af4d77f7fc
https://doi.org/10.1002/(sici)1097-4652(199708)172:2<200::aid-jcp7>3.0.co

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A complex pattern of mutations and abnormal splicing of Smad4 is present in thyroid tumours

Autor: Alessandra Turco, Davide Lazzereschi, Anna Coppa, Laura Ottini, Francesco Nardi, Cristina D'Amico, Alberto Gulino, Renato Mariani-Costantini

Publikováno v: Oncogene. 24(34)

Sensitivity to transforming growth factor-beta is impaired in thyroid tumours. Similar to Mad -- Mother Against Decapentaplegic-(Smad)4 is frequently altered in cancers, but its involvement in this system is unknown. We analysed 56 thyroid tumours of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8a06153edc686f0590720c3969d3e8a
https://pubmed.ncbi.nlm.nih.gov/15940269

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hDAF expression in hearts of transgenic pigs obtained by sperm-mediated gene transfer

Publikováno v: Europe PubMed Central

TRANSPLANTATON has been the choice option to treat successfully an increasing number of acute and chronic human pathologies with declining morbidity and mortality. However, availability of organs from human donors is limited and dramatically inadequa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18d2770cce66dd143c99de324e6d38a2
https://pubmed.ncbi.nlm.nih.gov/10936263

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Human decay accelerating factor transgenic pigs for xenotransplantation obtained by sperm-mediated gene transfer

Publikováno v: Transplantation proceedings. 31(1-2)

UMAN organs for transplantation are insufficient in quantity, and for every organ transplant undertaken there is a need for an additional five to ten organs. Waiting lists are constantly growing and many patients die before an organ can be found. Res

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7ba161444a95451e94ca9b243da8940
https://pubmed.ncbi.nlm.nih.gov/10083433

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Heregulin-dependent autocrine loop regulates growth of K-ras but not erbB-2 transformed rat thyroid epithelial cells

Autor: Gabriella Mincione, David S. Salomon, Davide Lazzereschi, Giulia Colletta, Alessandro Piccirelli

Publikováno v: Journal of cellular physiology. 176(2)

The EGF-like family of proteins, such as epidermal growth factor (EGF), transforming growth factor α (TGFα), amphiregulin (AR), betacellulin (BTC), cripto-1 (CR-1), and heregulin (HRG), plays an important role in the pathogenesis of several human c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78fdc2b3fe1ab29cdd2fddd5e00f5b59
https://pubmed.ncbi.nlm.nih.gov/9648926

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