Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Davide Guggi"'
Autor:
Sabbir Khan, Xiao-Long Li, Dimpy Koul, Thomas Mehrling, John DeGroot, Veerakumar Balasubramaniyan, Davide Guggi
Publikováno v:
Neuro-Oncology. 23:vi81-vi81
Glioblastoma (GBM) remains an incurable tumor with median overall survival of 15 months despite radiation and alkylating temozolomide (TMZ) chemotherapy. DNA damage response (DDR) pathways are among the most important key players of oncogenic mutatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::64786b8a690d2b74d3d09364a38830b9
https://doi.org/10.1093/neuonc/noab196.317
https://doi.org/10.1093/neuonc/noab196.317
Publikováno v:
International Journal of Pharmaceutics. 307:270-277
The goal of this study was to develop a microparticulate delivery system based on a thiolated chitosan conjugate for the nasal application of peptides. Insulin was used as model peptide. For thiolation of chitosan 2-iminothiolane was covalently linke
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf0b88b64e7ccaeae9261567563d4175
https://doi.org/10.1016/j.ijpharm.2005.10.016
https://doi.org/10.1016/j.ijpharm.2005.10.016
Publikováno v:
Advanced Drug Delivery Reviews. 57:1713-1723
In this study the mucoadhesive potential of nineteen different, most often referred mucoadhesive polymers was evaluated and characterized by adhesion time and total work of adhesion (TWA) of the polymer to porcine small intestinal mucosa. In addition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adb5e378dd3f92b7e22d763e890995de
https://doi.org/10.1016/j.addr.2005.07.006
https://doi.org/10.1016/j.addr.2005.07.006
Autor:
Christian W. Huck, Gudrun Schöffmann, Yvonne Pinter, Maria Dorly Del Curto, Mauro D'Antonio, Hermann Kahlbacher, Pierandrea Esposito, Maximilian Schuh, I. Schmerold, Davide Guggi, Andreas Bernkop-Schnürch
Publikováno v:
Journal of Controlled Release. 106:26-33
It was the aim of this study to develop an oral delivery system for the peptide drug antide. The stability of the therapeutic peptide towards gastrointestinal peptidases was evaluated. The therapeutic agent and the permeation mediator glutathione wer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::268c7ca2966f22dae0d0401cec2bbb7c
https://doi.org/10.1016/j.jconrel.2005.04.004
https://doi.org/10.1016/j.jconrel.2005.04.004
Autor:
Davide Guggi, Andreas Bernkop-Schnürch
Publikováno v:
International Journal of Pharmaceutics. 288:141-150
This study had the purpose to improve the paracellular uptake of drugs by combining the thiomer/reduced glutathione (GSH) permeation-enhancing system with a proteolytic enzyme. Due to the covalent binding of 2-iminothiolane to chitosan the thiomer ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df19cc2601143695eeae98952350f390
https://doi.org/10.1016/j.ijpharm.2004.09.023
https://doi.org/10.1016/j.ijpharm.2004.09.023
Publikováno v:
Journal of Controlled Release. 100:87-95
It was the aim of this study to develop and evaluate a nasal microparticulate delivery system for human growth hormone (hGH) based on the thiomer polycarbophil-cysteine (PCP-Cys) in combination with the permeation mediator glutathione (GSH). Micropar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bac92566597de858879a3822c295ba7
https://doi.org/10.1016/j.jconrel.2004.08.001
https://doi.org/10.1016/j.jconrel.2004.08.001
Publikováno v:
International Journal of Pharmaceutics. 278:353-360
d -Glucosamine and chitosan were modified by the immobilization of thiol groups utilizing 2-iminothiolane. The toxicity profile of the resulting d -glucosamine-TBA (4-thiobutylamidine) conjugate, of chitosan-TBA conjugate and of the corresponding unm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::722a547465b6e32f5f9ea4c5266ba43e
https://doi.org/10.1016/j.ijpharm.2004.03.016
https://doi.org/10.1016/j.ijpharm.2004.03.016
Publikováno v:
International Journal of Pharmaceutics. 274:97-105
This study examined the influence of the pH on the mucoadhesive and cohesive properties of polyarcylic acid (PAA) and thiolated PAA. The pH of PAA (molecular mass: 450 kDa) and of a corresponding PAA-cysteine conjugate was adjusted to 3, 4, 5, 6, 7 a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4609755e7606c85e1ede85844ca8cf2
https://doi.org/10.1016/j.ijpharm.2003.06.001
https://doi.org/10.1016/j.ijpharm.2003.06.001
Publikováno v:
Journal of Controlled Release. 95:547-555
It was the aim of this study to develop a delivery system providing an improved efficacy of orally administered insulin utilizing a thiolated polymer. 2-Iminothiolane was covalently linked to chitosan. The resulting chitosan-TBA (chitosan-4-thiobutyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de520f4a4824a93c3bead5d30f267703
https://doi.org/10.1016/j.jconrel.2003.12.017
https://doi.org/10.1016/j.jconrel.2003.12.017
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 57:9-17
The derivatization of the primary amino groups of chitosan with coupling reagents bearing thiol functions leads to the formation of thiolated chitosans. So far, three types of thiolated chitosans have been generated: chitosan-cysteine conjugates, chi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74d588470682ef8f13ee600adbe64f2d
https://doi.org/10.1016/s0939-6411(03)00147-4
https://doi.org/10.1016/s0939-6411(03)00147-4