Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Davide Gornati"'
Autor:
Elisa Fagnani, Francesco Bonì, Pierfausto Seneci, Davide Gornati, Luca Muzio, Eloise Mastrangelo, Mario Milani
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 23, Iss , Pp 1088-1093 (2024)
The stabilization of the retromer protein complex can be effective in the treatment of different neurological disorders. Following the identification of bis-1,3-phenyl guanylhydrazone 2a as an effective new compound for the treatment of amyotrophic l
Externí odkaz:
https://doaj.org/article/1cd32817805240faa098c6e2c29a04ba
Autor:
Luca Muzio, Riccardo Sirtori, Davide Gornati, Simona Eleuteri, Andrea Fossaghi, Diego Brancaccio, Leonardo Manzoni, Linda Ottoboni, Luca De Feo, Angelo Quattrini, Eloise Mastrangelo, Luca Sorrentino, Emanuele Scalone, Giancarlo Comi, Luciana Marinelli, Nilo Riva, Mario Milani, Pierfausto Seneci, Gianvito Martino
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
ALS is a neurodegenerative disease characterized by loss of motor neurons. Here, the authors showed that reduced levels of the VSP35 subunit in the retromer complex is a conserved ALS feature and identified a new lead compound increasing retromer sta
Externí odkaz:
https://doaj.org/article/2a79c2c4685b4d2598d773092d995d7b
Publikováno v:
Results in Chemistry, Vol 4, Iss , Pp 100654- (2022)
An efficient synthetic route was set up to prepare in good scale M-108, a novel bicycle derivative recently identified as a potent and selective G9a inhibitor, potentially useful as anti-fibroadipogenic agent. In particular, a facile three-steps sequ
Externí odkaz:
https://doaj.org/article/541b77a011324d9aa43adcccd223c3a1
Autor:
Pietro Randazzo, Roberta Sinisi, Davide Gornati, Stefania Bertuolo, Leda Bencheva, Marilenia De Matteo, Martina Nibbio, Edith Monteagudo, Lorenzo Turcano, Valeria Bianconi, Giovanna Peruzzi, Vincenzo Summa, Alberto Bresciani, Chiara Mozzetta, Romano Di Fabio
Publikováno v:
Bioorganicmedicinal chemistry letters. 72
A new series of in vitro potent and highly selective histone methyl transferase enzyme G9a inhibitors was obtained. In particular, compound 2a, one the most potent G9a inhibitor identified, was endowed with >130-fold selectivity over GLP and excellen
Autor:
Giuseppe Pignataro, Anna Pannaccione, Lucio Annunziato, Antonio Vinciguerra, Erika Pizzi, Tiziana Petrozziello, Agnese Secondo, Stefania Ippati, Eloise Mastrangelo, Andrea Menegon, Pietro Randazzo, Stefano Barbini, Cecilia Caccavone, Mario Milani, Roselia Ciccone, Luca Muzio, Pierfausto Seneci, Davide Gornati, Eleonora Colombo, Amal Z. Hassan
Publikováno v:
Journal of medicinal chemistry (Online) 64 (2021): 8333–8353. doi:10.1021/acs.jmedchem.1c00305
info:cnr-pdr/source/autori:Gornati D.; Ciccone R.; Vinciguerra A.; Ippati S.; Pannaccione A.; Petrozziello T.; Pizzi E.; Hassan A.; Colombo E.; Barbini S.; Milani M.; Caccavone C.; Randazzo P.; Muzio L.; Annunziato L.; Menegon A.; Secondo A.; Mastrangelo E.; Pignataro G.; Seneci P./titolo:Synthesis and Characterization of Novel Mono-And Bis-Guanyl Hydrazones as Potent and Selective ASIC1 Inhibitors Able to Reduce Brain Ischemic Insult/doi:10.1021%2Facs.jmedchem.1c00305/rivista:Journal of medicinal chemistry (Online)/anno:2021/pagina_da:8333/pagina_a:8353/intervallo_pagine:8333–8353/volume:64
info:cnr-pdr/source/autori:Gornati D.; Ciccone R.; Vinciguerra A.; Ippati S.; Pannaccione A.; Petrozziello T.; Pizzi E.; Hassan A.; Colombo E.; Barbini S.; Milani M.; Caccavone C.; Randazzo P.; Muzio L.; Annunziato L.; Menegon A.; Secondo A.; Mastrangelo E.; Pignataro G.; Seneci P./titolo:Synthesis and Characterization of Novel Mono-And Bis-Guanyl Hydrazones as Potent and Selective ASIC1 Inhibitors Able to Reduce Brain Ischemic Insult/doi:10.1021%2Facs.jmedchem.1c00305/rivista:Journal of medicinal chemistry (Online)/anno:2021/pagina_da:8333/pagina_a:8353/intervallo_pagine:8333–8353/volume:64
Acid-sensitive ion channels (ASICs) are sodium channels partially permeable to Ca2+ ions, listed among putative targets in central nervous system (CNS) diseases in which a pH modification occurs. We targeted novel compounds able to modulate ASIC1 and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e7c20a7c07be1a20f4dc57376a9ac3f
http://www.cnr.it/prodotto/i/458062
http://www.cnr.it/prodotto/i/458062
Autor:
Giulia Assoni, Giulia Frapporti, Daniela Arosio, Eleonora Colombo, María D. Pérez-Carrión, Giovanni Piccoli, Davide Gornati, Pierfausto Seneci, Laura Polito
Publikováno v:
Bioorganic & medicinal chemistry letters
40 (2021). doi:10.1016/j.bmcl.2021.127929
info:cnr-pdr/source/autori:Assoni, Giulia; Frapporti, Giulia; Colombo, Eleonora; Gornati, Davide; Perez-Carrion, Maria Dolores; Polito, Laura; Seneci, Pierfausto; Piccoli, Giovanni; Arosio, Daniela/titolo:Trehalose-based neuroprotective autophagy inducers/doi:10.1016%2Fj.bmcl.2021.127929/rivista:Bioorganic & medicinal chemistry letters (Print)/anno:2021/pagina_da:/pagina_a:/intervallo_pagine:/volume:40
40 (2021). doi:10.1016/j.bmcl.2021.127929
info:cnr-pdr/source/autori:Assoni, Giulia; Frapporti, Giulia; Colombo, Eleonora; Gornati, Davide; Perez-Carrion, Maria Dolores; Polito, Laura; Seneci, Pierfausto; Piccoli, Giovanni; Arosio, Daniela/titolo:Trehalose-based neuroprotective autophagy inducers/doi:10.1016%2Fj.bmcl.2021.127929/rivista:Bioorganic & medicinal chemistry letters (Print)/anno:2021/pagina_da:/pagina_a:/intervallo_pagine:/volume:40
A small set of trehalose-centered putative autophagy inducers was rationally designed and synthesized, with the aim to identify more potent and bioavailable autophagy inducers than free trehalose, and to acquire information about their molecular mech
Autor:
Pierfausto Seneci, Leonardo Manzoni, Silvia Cairati, Davide Gornati, Daniela Arosio, Daniele Lecis, Alberto Bossi, Mattia Manzotti
Publikováno v:
Bioorganic & medicinal chemistry letters
26 (2016): 4613–4619. doi:10.1016/j.bmcl.2016.08.065
info:cnr-pdr/source/autori:Manzoni, Leonardo; Gornati, Davide; Manzotti, Mattia; Cairati, Silvia; Bossi, Alberto; Arosio, Daniela; Lecis, Daniele; Seneci, Pierfausto/titolo:Dual action Smac mimetics-zinc chelators as pro-apoptotic antitumoral agents/doi:10.1016%2Fj.bmcl.2016.08.065/rivista:Bioorganic & medicinal chemistry letters (Print)/anno:2016/pagina_da:4613/pagina_a:4619/intervallo_pagine:4613–4619/volume:26
26 (2016): 4613–4619. doi:10.1016/j.bmcl.2016.08.065
info:cnr-pdr/source/autori:Manzoni, Leonardo; Gornati, Davide; Manzotti, Mattia; Cairati, Silvia; Bossi, Alberto; Arosio, Daniela; Lecis, Daniele; Seneci, Pierfausto/titolo:Dual action Smac mimetics-zinc chelators as pro-apoptotic antitumoral agents/doi:10.1016%2Fj.bmcl.2016.08.065/rivista:Bioorganic & medicinal chemistry letters (Print)/anno:2016/pagina_da:4613/pagina_a:4619/intervallo_pagine:4613–4619/volume:26
Dual action compounds (DACs) based on 4-substituted aza-bicyclo[5.3.0] decane Smac mimetic scaffolds (ABDs) linked to a Zn2+-chelating moiety (DPA, o-hydroxy, m-allyl, N-acyl (E)-phenylhydrazone) through their 10 position are reported and characteriz
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