Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Davide Genini"'
Autor:
Davide Genini
Publikováno v:
European Papers, Vol 2024 9, Iss 1, Pp 145-152 (2024)
(Series Information) European Papers - A Journal on Law and Integration, 2024 9(1), 145-152 | European Forum Insight of 25 June 2024 | (Table of Contents) I. Introduction. - II. The signature of international agreements into EU law and the emergence
Externí odkaz:
https://doaj.org/article/8625f0bc6dcd4f4b9538e8a1cb93dcef
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e46009 (2012)
Peroxisome proliferator-activated receptor β/δ (PPARβ/δ) is a nuclear receptor involved in regulation of lipid and glucose metabolism, wound healing and inflammation. PPARβ/δ has been associated also with cancer. Here we investigated the expres
Externí odkaz:
https://doaj.org/article/9ac73be4b28044339e5ff6ec2ac3344f
Publikováno v:
PPAR Research, Vol 2008 (2008)
The peroxisome proliferator-activated receptors (PPAR) α, β/δ, and γ are ligand-activated nuclear receptors involved in a number of physiological processes, including lipid and glucose homeostasis, inflammation, cell growth, differentiation, and
Externí odkaz:
https://doaj.org/article/fdc9c4f4d7cb4055ace0e78ae200c654
Autor:
Francesco Bertoni, Jeffrey A. Toretsky, Brian Lannutti, Anastasios Stathis, Emanuele Zucca, B. Hilda Ye, Davide Genini, Monica Testoni, Ivo Kwee, Andrea Rinaldi, Andrea Cavalli, Saravana P. Selvanathan, Garrett Graham, Giulio Sartori, Valdemar Priebe, Laura Carrassa, Katti Jessen, Sara Napoli, Luciano Cascione, Chiara Tarantelli, Eugenio Gaudio, Elaine Yee Lin Chung, Filippo Spriano
YK-4-279 and TK-216 combinations. For each combination, the table shows the median Combination Index (CI) obtained after exposing cell lines to increasing concentration of two compounds at 8 x 8 concentrations of each compound (removing concentration
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4c30ef7f9a26307b66016b74d333ac1
https://doi.org/10.1158/1078-0432.22473042
https://doi.org/10.1158/1078-0432.22473042
Autor:
Francesco Bertoni, Jeffrey A. Toretsky, Brian Lannutti, Anastasios Stathis, Emanuele Zucca, B. Hilda Ye, Davide Genini, Monica Testoni, Ivo Kwee, Andrea Rinaldi, Andrea Cavalli, Saravana P. Selvanathan, Garrett Graham, Giulio Sartori, Valdemar Priebe, Laura Carrassa, Katti Jessen, Sara Napoli, Luciano Cascione, Chiara Tarantelli, Eugenio Gaudio, Elaine Yee Lin Chung, Filippo Spriano
Purpose:Transcription factors are commonly deregulated in cancer, and they have been widely considered as difficult to target due to their nonenzymatic mechanism of action. Altered expression levels of members of the ETS-transcription factors are oft
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::206542a8a12efab2866cc9fcd205d19b
https://doi.org/10.1158/1078-0432.c.6528405
https://doi.org/10.1158/1078-0432.c.6528405
Autor:
Ivo Kwee, Laura Carrassa, Monica Testoni, Katti Jessen, B. Hilda Ye, Emanuele Zucca, Filippo Spriano, Davide Genini, Valdemar Priebe, Chiara Tarantelli, Giulio Sartori, Brian J. Lannutti, Saravana P. Selvanathan, Jeffrey A. Toretsky, Sara Napoli, Andrea Cavalli, Elaine Yee Lin Chung, Andrea Rinaldi, Anastasios Stathis, Francesco Bertoni, Eugenio Gaudio, Garrett T. Graham, Luciano Cascione
Publikováno v:
Clinical Cancer Research. 25:5167-5176
Purpose: Transcription factors are commonly deregulated in cancer, and they have been widely considered as difficult to target due to their nonenzymatic mechanism of action. Altered expression levels of members of the ETS-transcription factors are of
Autor:
Erik Laurini, Laurent Perez, Gianluca Civenni, Jessica Merulla, Sabrina Pricl, Carlo V. Catapano, Rocco D'Antuono, David E. Levy, Shusil Pandit, Davide Genini, Giuseppina M. Carbone, Lara Brambilla
In addition to its canonical role in nuclear transcription, signal transducer and activator of transcription 3 (STAT3) is emerging as an important regulator of mitochondrial function. Here, we demonstrate that a novel inhibitor that binds with high a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f46463b113fd076f8b67a7cd95b7109
http://doc.rero.ch/record/324258/files/Genini_PNAS_2017.pdf
http://doc.rero.ch/record/324258/files/Genini_PNAS_2017.pdf
Autor:
Davide Genini, Carlo V. Catapano
Publikováno v:
Journal of Biological Chemistry. 282:11776-11785
Peroxisome proliferator-activated receptor δ (PPARδ) is a ligand-activated transcription factor involved in many physiological and pathological processes. PPARδ is a promising therapeutic target for metabolic, chronic inflammatory, and neurodegene
Autor:
Rolf Krause, Davide Genini, Carlo V. Catapano, Andrea Cavalli, Dariusz Ekonomiuk, Simon Olsson, Jacopo Sgrignani
Publikováno v:
Biochemistry. 54(35)
Signal transducer and activator of transcription factors (STATs) are proteins that can translocate into the nucleus, bind DNA, and activate gene transcription. STAT proteins play a crucial role in cell proliferation, apoptosis, and differentiation. T
Autor:
Laurent Perez, Davide Genini, Giuseppina M. Carbone, Jessica Merulla, Sabrina Pricl, Carlo V. Catapano, Erik Laurini, Maurizio Fermeglia, Lara Brambilla
STAT3 is a key element in many oncogenic pathways and, like other transcription factors, is an attractive target for development of novel anticancer drugs. However, interfering with STAT3 functions has been a difficult task and very few small molecul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::def0e602fdf10ade88358c7d1bd557ed
https://europepmc.org/articles/PMC5528765/
https://europepmc.org/articles/PMC5528765/