Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Davide Danovi"'
Autor:
Haneen S. Alsehli, Errin Roy, Thomas Williams, Alicja Kuziola, Yunzhe Guo, Cecile A. Dreiss, Jeremy B.A. Green, Eileen Gentleman, Davide Danovi
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 12 (2024)
IntroductionCell lineage specification is tightly associated with profound morphological changes in the developing human embryo, particularly during gastrulation. The interplay between mechanical forces and biochemical signals is poorly understood.Me
Externí odkaz:
https://doaj.org/article/b25bac5cac2a45629d828abf4aa2484d
Autor:
Chang Lu, Jan Zaucha, Rihab Gam, Hai Fang, Ben Smithers, Matt E. Oates, Miguel Bernabe-Rubio, James Williams, Natalie Zelenka, Arun Prasad Pandurangan, Himani Tandon, Hashem Shihab, Raju Kalaivani, Minkyung Sung, Adam J. Sardar, Bastian Greshake Tzovoras, Davide Danovi, Julian Gough
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Systematically predicting phenotypes or disease risks based on the information of an individual’s genetic variation remains an unsolved challenge. Here, the authors develop a knowledge-based approach for performing and evaluating hypothesis-free ph
Externí odkaz:
https://doaj.org/article/fe21f256cb6b4004bd97bf5b493f46e6
Autor:
James Williams, Chloe Hurling, Sabrina Munir, Peter Harley, Carolina Barcellos Machado, Ana-Maria Cujba, Mario Alvarez-Fallas, Davide Danovi, Ivo Lieberam, Rocio Sancho, Philip Beales, Fiona M. Watt
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Bardet-Biedl syndrome (BBS) is a ciliopathy with pleiotropic effects on multiple tissues, including the kidney. Here we have compared renal differentiation of iPS cells from healthy and BBS donors. High content image analysis of WT1-expressing kidney
Externí odkaz:
https://doaj.org/article/d171a7913adc46668842c8c82971940f
Publikováno v:
Journal of Tissue Engineering, Vol 14 (2023)
Skeletal muscle-derived cells (SMDC) hold tremendous potential for replenishing dysfunctional muscle lost due to disease or trauma. Current therapeutic usage of SMDC relies on harvesting autologous cells from muscle biopsies that are subsequently exp
Externí odkaz:
https://doaj.org/article/16e3c6ff62854c10b56944c1415d1fe6
Autor:
Chao Zheng Li, Hiromi Ogawa, Soon Seng Ng, Xindi Chen, Eriko Kishimoto, Kokoro Sakabe, Aiko Fukami, Yueh-Chiang Hu, Christopher N. Mayhew, Jennifer Hellmann, Alexander Miethke, Nahrin L. Tasnova, Samuel J.I. Blackford, Zu Ming Tang, Adam M. Syanda, Liang Ma, Fang Xiao, Melissa Sambrotta, Oliver Tavabie, Filipa Soares, Oliver Baker, Davide Danovi, Hisamitsu Hayashi, Richard J. Thompson, S. Tamir Rashid, Akihiro Asai
Publikováno v:
JHEP Reports, Vol 4, Iss 4, Pp 100446- (2022)
Background & Aims: The truncating mutations in tight junction protein 2 (TJP2) cause progressive cholestasis, liver failure, and hepatocyte carcinogenesis. Due to the lack of effective model systems, there are no targeted medications for the liver pa
Externí odkaz:
https://doaj.org/article/a3897953261242379e6856ff67f6e514
Autor:
John Ong, Maria Paola Serra, Joe Segal, Ana-Maria Cujba, Soon Seng Ng, Richard Butler, Val Millar, Stephanie Hatch, Salman Zimri, Hiroyuki Koike, Karen Chan, Andrew Bonham, Michelle Walk, Ty Voss, Nigel Heaton, Ragai Mitry, Anil Dhawan, Daniel Ebner, Davide Danovi, Hiromitsu Nakauchi, S. Tamir Rashid
Publikováno v:
Stem Cell Reports, Vol 10, Iss 3, Pp 693-702 (2018)
Summary: Use of hepatocytes derived from induced pluripotent stem cells (i-Heps) is limited by their functional differences in comparison with primary cells. Extracellular niche factors likely play a critical role in bridging this gap. Using image-ba
Externí odkaz:
https://doaj.org/article/7c1f980085ad4d33ad10a8f4d8dd7616
Autor:
Mukul Tewary, Dominika Dziedzicka, Joel Ostblom, Laura Prochazka, Nika Shakiba, Tiam Heydari, Daniel Aguilar-Hidalgo, Curtis Woodford, Elia Piccinini, David Becerra-Alonso, Alice Vickers, Blaise Louis, Nafees Rahman, Davide Danovi, Mieke Geens, Fiona M Watt, Peter W Zandstra
Publikováno v:
PLoS Biology, Vol 17, Iss 10, p e3000081 (2019)
In vitro models of postimplantation human development are valuable to the fields of regenerative medicine and developmental biology. Here, we report characterization of a robust in vitro platform that enabled high-content screening of multiple human
Externí odkaz:
https://doaj.org/article/3d54779845f24e319469e56edbe389d3
Autor:
William B. Barrell, John N. Griffin, Jessica-Lily Harvey, HipSci Consortium, Davide Danovi, Philip Beales, Agamemnon E. Grigoriadis, Karen J. Liu, Richard Durbin, Daniel Gaffney, Chukwuma Agu, Alex Alderton, Shrada Amatya, Petr Danecek, Rachel Denton, Angela Goncalves, Reena Halai, Sarah Harper, Chris Kirton, Andrew Knights, Anja Kolb-Kokocinski, Andreas Leha, Shane McCarthy, Yasin Memari, Minal Patel, Ewan Birney, Oliver Stegle, Francesco Paolo Casale, Laura Clarke, Peter Harrison, Helena Kilpinen, Davis McCarthy, Ian Streeter, Fiona Watt, Davide Denovi, Ruta Meleckyte, Natalie Moens, Willem Ouwehand, Ludovic Vallier, Angus Lamond, Dalila Bensaddek
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 12 (2019)
Neural crest cells arise in the embryo from the neural plate border and migrate throughout the body, giving rise to many different tissue types such as bones and cartilage of the face, smooth muscles, neurons, and melanocytes. While studied extensive
Externí odkaz:
https://doaj.org/article/3dc064c4ac76449b82dd6ccf0dc8ab8c
Autor:
Alessandra Vigilante, Anna Laddach, Nathalie Moens, Ruta Meleckyte, Andreas Leha, Arsham Ghahramani, Oliver J. Culley, Annie Kathuria, Chloe Hurling, Alice Vickers, Erika Wiseman, Mukul Tewary, Peter W. Zandstra, Richard Durbin, Franca Fraternali, Oliver Stegle, Ewan Birney, Nicholas M. Luscombe, Davide Danovi, Fiona M. Watt
Publikováno v:
Cell Reports, Vol 26, Iss 8, Pp 2078-2087.e3 (2019)
Summary: Large cohorts of human induced pluripotent stem cells (iPSCs) from healthy donors are a potentially powerful tool for investigating the relationship between genetic variants and cellular behavior. Here, we integrate high content imaging of c
Externí odkaz:
https://doaj.org/article/e47a80c1787e4bf88999cbaafa6e98f8
Autor:
Davide Danovi, Amos Folarin, Sabine Gogolok, Christine Ender, Ahmed M O Elbatsh, Pär G Engström, Stefan H Stricker, Sladjana Gagrica, Ana Georgian, Ding Yu, Kin Pong U, Kevin J Harvey, Patrizia Ferretti, Patrick J Paddison, Jane E Preston, N Joan Abbott, Paul Bertone, Austin Smith, Steven M Pollard
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e77053 (2013)
Glioblastoma multiforme (GBM) is the most common primary brain cancer in adults and there are few effective treatments. GBMs contain cells with molecular and cellular characteristics of neural stem cells that drive tumour growth. Here we compare resp
Externí odkaz:
https://doaj.org/article/19166962924b408289d08b363d1c7682