Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Davide Costabile"'
Autor:
Mariella Cuomo, Lorena Coretti, Davide Costabile, Rosa Della Monica, Giulia De Riso, Michela Buonaiuto, Federica Trio, Carmela Bravaccio, Roberta Visconti, Roberto Berni Canani, Lorenzo Chiariotti, Francesca Lembo
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-9 (2023)
Abstract The gut-brain axis involves several bidirectional pathway communications including microbiome, bacterial metabolites, neurotransmitters as well as immune system and is perturbed both in brain and in gastrointestinal disorders. Consistently,
Externí odkaz:
https://doaj.org/article/d30f2e7126524298808cea87d3d9dd77
Autor:
Rosa Della Monica, Michela Buonaiuto, Mariella Cuomo, Cristina Pagano, Federica Trio, Davide Costabile, Giulia de Riso, Francesca Sveva Cicala, Maddalena Raia, Raduan Ahmed Franca, Marialaura Del Basso De Caro, Domenico Sorrentino, Giovanna Navarra, Laura Coppola, Lorella Tripodi, Lucio Pastore, Juergen Hench, Stephan Frank, Claudio Schonauer, Giuseppe Catapano, Maurizio Bifulco, Lorenzo Chiariotti, Roberta Visconti
Publikováno v:
Cell Death and Disease, Vol 14, Iss 9, Pp 1-13 (2023)
Abstract Despite intense research efforts, glioblastoma remains an incurable brain tumor with a dismal median survival time of 15 months. Thus, identifying new therapeutic targets is an urgent need. Here, we show that the lysine methyltransferase SET
Externí odkaz:
https://doaj.org/article/b44f13ef57b24faa81bbd847d68a87ec
Autor:
Mariella Cuomo, Ermanno Florio, Rosa Della Monica, Davide Costabile, Michela Buonaiuto, Teodolinda Di Risi, Giulia De Riso, Antonella Sarnataro, Sergio Cocozza, Roberta Visconti, Lorenzo Chiariotti
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract FXYD1 is a key protein controlling ion channel transport. FXYD1 exerts its function by regulating Na+/K+-ATPase activity, mainly in brain and cardiac tissues. Alterations of the expression level of the FXYD1 protein cause diastolic dysfuncti
Externí odkaz:
https://doaj.org/article/723c168e91414290925a909beb7325af
Autor:
Liliana Montella, Nunzio Del Gaudio, Guglielmo Bove, Mariella Cuomo, Michela Buonaiuto, Davide Costabile, Roberta Visconti, Gaetano Facchini, Lucia Altucci, Lorenzo Chiariotti, Rosa Della Monica
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Glioblastomas are the most frequent and malignant brain tumor hallmarked by an invariably poor prognosis. They have been classically differentiated into primary isocitrate dehydrogenase 1 or 2 (IDH1 -2) wild-type (wt) glioblastoma (GBM) and secondary
Externí odkaz:
https://doaj.org/article/70f43cceeed8489eac57e87cf301a107
Autor:
Alfredo Marinelli, Mariella Cuomo, Raduan Ahmed Franca, Michela Buonaiuto, Davide Costabile, Cristina Pagano, Federica Trio, Liliana Montella, Maria Laura Del Basso De Caro, Roberta Visconti, Lorenzo Chiariotti, Rosa Della Monica
Publikováno v:
Brain Sciences, Vol 13, Iss 2, p 235 (2023)
Diagnoses of primary malignant mesenchymal brain tumors are a challenge for pathologists. Here, we report the case of a 52-year-old man with a primary brain tumor, histologically diagnosed as a high-grade glioma, not otherwise specified (NOS). The pa
Externí odkaz:
https://doaj.org/article/c97901a2bb884ddbaa4b39cb79f7f17c
Autor:
Teodolinda Di Risi, Mariella Cuomo, Roberta Vinciguerra, Sara Ferraro, Rosa Della Monica, Davide Costabile, Michela Buonaiuto, Federica Trio, Ettore Capoluongo, Roberta Visconti, Eleonora Riccio, Antonio Pisani, Lorenzo Chiariotti
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 20, p 12110 (2022)
Anderson–Fabry disease (FD) is an X-linked disease caused by a functional deficit of the α-galactosidase A enzyme. FD diagnosis relies on the clinical manifestations and research of GLA gene mutations. However, because of the lack of a clear genot
Externí odkaz:
https://doaj.org/article/8a5dd10d9f74462aa9f7dbebc1e12da4
Autor:
Rosa Della Monica, Mariella Cuomo, Michela Buonaiuto, Davide Costabile, Raduan Ahmed Franca, Marialaura Del Basso De Caro, Giuseppe Catapano, Lorenzo Chiariotti, Roberta Visconti
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 13, p 7148 (2022)
Epigenetic changes in DNA methylation contribute to the development of many diseases, including cancer. In glioblastoma multiforme, the most prevalent primary brain cancer and an incurable tumor with a median survival time of 15 months, a single epig
Externí odkaz:
https://doaj.org/article/cf0d41500ef6459dbf39595dec336ab1
Autor:
Giulia De Riso, Mariella Cuomo, Teodolinda Di Risi, Rosa Della Monica, Michela Buonaiuto, Davide Costabile, Antonio Pisani, Sergio Cocozza, Lorenzo Chiariotti
Publikováno v:
Genes, Vol 11, Iss 6, p 620 (2020)
Recessive X-linked disorders may occasionally evolve in clinical manifestations of variable severity also in female carriers. For some of such diseases, the frequency of the symptoms’ appearance during women’s life may be particularly relevant. T
Externí odkaz:
https://doaj.org/article/0db7cf1deeee4f7d8e7565583206f8e5
Autor:
Davide Costabile, Giulia De Riso, Paolo Cappabianca, Stephan Frank, Salvatore Tafuto, Alessandro Ottaiano, Annabella Di Mauro, Roberto Tafuto, Rosa Della Monica, Lorenzo Chiariotti, Roberta Visconti, Sabrina Lamia, Fabiana Tatangelo, Marialaura Del Basso De Caro, Juergen Hench, Michela Buonaiuto, Mariella Cuomo, Elia Guadagno, Teodolinda Di Risi
Publikováno v:
Oncology Research
Unresectable neuroendocrine neoplasms (NENs) often poorly respond to standard therapeutic approaches. Alkylating agents, in particular temozolomide, commonly used to treat high-grade brain tumors including glioblastomas, have recently been tested in
Autor:
Liliana Montella, Mariella Cuomo, Nunzio Del Gaudio, Michela Buonaiuto, Davide Costabile, Roberta Visconti, Teodolinda Di Risi, Roberta Vinciguerra, Federica Trio, Sara Ferraro, Guglielmo Bove, Gaetano Facchini, Lucia Altucci, Lorenzo Chiariotti, Rosa Della Monica
Publikováno v:
International journal of cancer.
Glioblastoma, the most common and heterogeneous tumor affecting brain parenchyma, is dismally characterized by a very poor prognosis. Thus, the search of new, more effective treatments is a vital need. Here, we will review the druggable epigenetic fe