Zobrazeno 1 - 10
of 181
pro vyhledávání: '"Davide Calebiro"'
Autor:
Julia Ast, Daniela Nasteska, Nicholas H. F. Fine, Daniel J. Nieves, Zsombor Koszegi, Yann Lanoiselée, Federica Cuozzo, Katrina Viloria, Andrea Bacon, Nguyet T. Luu, Philip N. Newsome, Davide Calebiro, Dylan M. Owen, Johannes Broichhagen, David J. Hodson
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Visualizing endogenous GPCRs is challenging. Here the authors generate mice with an enzyme self-label genome-edited into the endogenous glucagon-like peptide-1 receptor locus, design fluorescent dyes for specific labelling in complex tissue, and reve
Externí odkaz:
https://doaj.org/article/a1c114f010cf4dc7bafcaf994b474beb
Autor:
Marie-Lise Jobin, Sana Siddig, Zsombor Koszegi, Yann Lanoiselée, Vladimir Khayenko, Titiwat Sungkaworn, Christian Werner, Kerstin Seier, Christin Misigaiski, Giovanna Mantovani, Markus Sauer, Hans M. Maric, Davide Calebiro
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
GABAB receptors mediate the effects of the main inhibitory neurotransmitter in the brain. Here, authors identify the cytoskeletal protein filamin A as a key player that controls the exact location and function of GABAB receptors at the cell surface.
Externí odkaz:
https://doaj.org/article/151c7286e0224e3e936b73cfadb10add
Autor:
Tobias Benkel, Mirjam Zimmermann, Julian Zeiner, Sergi Bravo, Nicole Merten, Victor Jun Yu Lim, Edda Sofie Fabienne Matthees, Julia Drube, Elke Miess-Tanneberg, Daniela Malan, Martyna Szpakowska, Stefania Monteleone, Jak Grimes, Zsombor Koszegi, Yann Lanoiselée, Shannon O’Brien, Nikoleta Pavlaki, Nadine Dobberstein, Asuka Inoue, Viacheslav Nikolaev, Davide Calebiro, Andy Chevigné, Philipp Sasse, Stefan Schulz, Carsten Hoffmann, Peter Kolb, Maria Waldhoer, Katharina Simon, Jesus Gomeza, Evi Kostenis
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)
Abstract Carvedilol is among the most effective β-blockers for improving survival after myocardial infarction. Yet the mechanisms by which carvedilol achieves this superior clinical profile are still unclear. Beyond blockade of β1-adrenoceptors, ar
Externí odkaz:
https://doaj.org/article/31913551d70443ecbc6be0521f89476a
Autor:
Donatella Treppiedi, Giusy Marra, Genesio Di Muro, Rosa Catalano, Federica Mangili, Emanuela Esposito, Davide Calebiro, Maura Arosio, Erika Peverelli, Giovanna Mantovani
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
The process of GPCR dimerization can have profound effects on GPCR activation, signaling, and intracellular trafficking. Somatostatin receptors (SSTs) are class A GPCRs abundantly expressed in pituitary tumors where they represent the main pharmacolo
Externí odkaz:
https://doaj.org/article/ea7432ff91a648e5afe643811db35589
Autor:
Julia Ast, Anastasia Arvaniti, Nicholas H. F. Fine, Daniela Nasteska, Fiona B. Ashford, Zania Stamataki, Zsombor Koszegi, Andrea Bacon, Ben J. Jones, Maria A. Lucey, Shugo Sasaki, Daniel I. Brierley, Benoit Hastoy, Alejandra Tomas, Giuseppe D’Agostino, Frank Reimann, Francis C. Lynn, Christopher A. Reissaus, Amelia K. Linnemann, Elisa D’Este, Davide Calebiro, Stefan Trapp, Kai Johnsson, Tom Podewin, Johannes Broichhagen, David J. Hodson
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Glucagon-like peptide-1 receptor is an important regulator of appetite and glucose homeostasis. Here the authors describe super-resolution microscopy and in vivo imaging compatible fluorescent probes, which reveal endogenous glucagon-like peptide-1 r
Externí odkaz:
https://doaj.org/article/1bec881e08194ff3b4ad84658e067529
Autor:
Aaron Novikoff, Shannon L. O'Brien, Miriam Bernecker, Gerald Grandl, Maximilian Kleinert, Patrick J. Knerr, Kerstin Stemmer, Martin Klingenspor, Anja Zeigerer, Richard DiMarchi, Matthias H. Tschöp, Brian Finan, Davide Calebiro, Timo D. Müller
Publikováno v:
Molecular Metabolism, Vol 49, Iss , Pp 101181- (2021)
Objective: We assessed the spatiotemporal GLP-1 and GIP receptor signaling, trafficking, and recycling dynamics of GIPR mono-agonists, GLP-1R mono-agonists including semaglutide, and GLP-1/GIP dual-agonists MAR709 and tirzepatide. Methods: Receptor G
Externí odkaz:
https://doaj.org/article/3747ffadfcfc4ababd52d92c0564e71b
Autor:
Anna Sofie Husted, Jeppe H. Ekberg, Emma Tripp, Tinne A.D. Nissen, Stijn Meijnikman, Shannon L. O'Brien, Trond Ulven, Yair Acherman, Sjoerd C. Bruin, Max Nieuwdorp, Zach Gerhart-Hines, Davide Calebiro, Lars O. Dragsted, Thue W. Schwartz
Publikováno v:
Molecular Metabolism, Vol 42, Iss , Pp 101103- (2020)
Objectives: Long-chain fatty acids (LCFAs) released from adipocytes inhibit lipolysis through an unclear mechanism. We hypothesized that the LCFA receptor, FFAR4 (GPR120), which is highly expressed in adipocytes, may be involved in this feedback regu
Externí odkaz:
https://doaj.org/article/dfb3bd9efe4a45b38a1d9a446ce4b2e5
Publikováno v:
Entropy, Vol 23, Iss 8, p 1044 (2021)
In this article, we introduce a new method to detect transient trapping events within a single particle trajectory, thus allowing the explicit accounting of changes in the particle’s dynamics over time. Our method is based on new measures of a smoo
Externí odkaz:
https://doaj.org/article/8b4c9e392b7b4054839df5acb6aa5a84
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Recent investigations suggest that G-protein-coupled receptors (GPCRs) can signal during intracellular trafficking. Here the authors use fluorescence microscopy approaches to directly visualize and investigate functional consequences of GPCR-mediated
Externí odkaz:
https://doaj.org/article/579404a03c0147afacf9210a0eb19e7e
Autor:
Isabel Weigand, Cristina L. Ronchi, Marthe Rizk-Rabin, Guido Di Dalmazi, Vanessa Wild, Kerstin Bathon, Beatrice Rubin, Davide Calebiro, Felix Beuschlein, Jérôme Bertherat, Martin Fassnacht, Silviu Sbiera
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Abstract Somatic mutations in protein kinase A catalytic α subunit (PRKACA) were found to be causative for 30–40% of cortisol-producing adenomas (CPA) of the adrenal gland, rendering PKA signalling constitutively active. In its resting state, PKA
Externí odkaz:
https://doaj.org/article/a7dfc728130647c9871d28bac6b0b73e