Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Davide Agnello"'
Autor:
Norma P. Gerard, Davide Agnello, Amandine Lavaux, Damien Denimal, Craig Gerard, Pierre Pothier, Leslie Blondeau-Germe, Bao Lu
Publikováno v:
The Journal of Immunology. 190:4836-4847
According to the current paradigm, lymphocyte homing to the small intestine requires the expression of two tissue-specific homing receptors, the integrin α4β7 and the CCL25 receptor CCR9. In this study, we investigated the organ distribution and th
Autor:
Albert Q. Lam, John J. O'Shea, Yuka Kanno, Yong-Jie Zhou, Davide Agnello, Richard J. Youle, Haydeé L. Ramos, Sigrun R. Hofmann, Stephan Frank
Publikováno v:
Molecular and Cellular Biology. 24:5039-5049
The Janus family of protein tyrosine kinases (Jaks) is a small family consisting of Jak1, Jak2, Jak3, and Tyk2 (11, 15, 19, 23). These kinases are structurally unique in possessing a carboxy-terminal kinase domain, along with a pseudokinase domain, w
Autor:
Pietro Ghezzi, Tiziana Mennini, Paolo Bigini, Marina Marinovich, Pia Villa, Alfredo Cagnotto, Teresa Laragione, Thomas Coleman, Michael Brines, Barbara Viviani, Anthony Cerami, Davide Agnello
Publikováno v:
The Journal of Experimental Medicine
Ischemic brain injury resulting from stroke arises from primary neuronal losses and by inflammatory responses. Previous studies suggest that erythropoietin (EPO) attenuates both processes. Although EPO is clearly antiapoptotic for neurons after exper
Autor:
David M. Frucht, Massimo Gadina, John J. O'Shea, Carla S. R. Lankford, Davide Agnello, Jay H. Bream, Akio Morinobu
Publikováno v:
Journal of Clinical Immunology. 23:147-161
The differentiation of naive CD4+ T cells into subsets of T helper cells is a pivotal process with major implications for host defense and the pathogenesis of immune-mediated diseases. Though the basic paradigm was discovered more than 15 years ago,
Autor:
Anthony Cerami, Michael Brines, Pietro Ghezzi, Tiziana Mennini, Pia Villa, Paolo Bigini, Davide Agnello
Publikováno v:
Brain Research. 952:128-134
In recent work we reported that systemically administered erythropoietin (EPO) crosses the blood-brain barrier and has protective effects in animal models of cerebral ischemia, brain trauma and in a rat model of experimental autoimmune encephalomyeli
Publikováno v:
Cytokine. 18:231-236
High-mobility group protein-1 (HMG-1 also termed HMGB-1), a DNA-binding protein, regulates gene transcription and stabilizes nucleosome formation. HMG-1 was recently implicated as a cytokine, because it is a late-acting mediator of endotoxin lethalit
Autor:
Pietro Ghezzi, Michael Brines, Loretta M. Itri, Sonja Keenan, Carla Cerami, Davide Agnello, Nihal C. de Lanerolle, Anthony Cerami
Publikováno v:
Proceedings of the National Academy of Sciences. 97:10526-10531
Erythropoietin (EPO), recognized for its central role in erythropoiesis, also mediates neuroprotection when the recombinant form (r-Hu-EPO) is directly injected into ischemic rodent brain. We observed abundant expression of the EPO receptor at brain
Autor:
Pietro Ghezzi, Antonello Marullo, Gianfranco Caselli, Riccardo Bertini, Silvano Sacco, Davide Agnello
Publikováno v:
Cytokine. 12:1205-1210
We investigated the relative contribution of IL-6 and PGE2 directly induced by LPS and indirectly induced via TNF, using in vivo and in vitro models in the mouse. In these models we have used as tools an anti-TNF antibody and a cyclooxygenase inhibit
Autor:
Elisabetta Gianazza, Ivano Eberini, Ruedi Aebersold, Ingrid Miller, Pia Villa, Davide Agnello, Maddalena Fratelli, Jason C. K. Chan, Manfred Gemeiner, Pietro Ghezzi
Publikováno v:
Electrophoresis. 21:2170-2180
The effect of adjuvant arthritis (AA) on the pattern of rat serum proteins includes the upregulation of haptoglobin, orosomucoid, alpha2-macroglobulin, serine protease inhibitor-3, thiostatin, alpha1-antitrypsin, C-reactive protein, and the downregul
Publikováno v:
Neuroimmunomodulation. 8:142-147
The effect of infection and inflammation of the central nervous system (CNS) on cytochrome-P450-dependent activities in brain, spinal cord and liver microsomes was determined. For this, two models were used: (1) the intracerebroventricularly injected