Zobrazeno 1 - 10
of 145
pro vyhledávání: '"Davide, Ruggero"'
Autor:
Irati Macaya, Marta Roman, Connor Welch, Rodrigo Entrialgo-Cadierno, Marina Salmon, Alba Santos, Iker Feliu, Joanna Kovalski, Ines Lopez, Maria Rodriguez-Remirez, Sara Palomino-Echeverria, Shane M. Lonfgren, Macarena Ferrero, Silvia Calabuig, Iziar A. Ludwig, David Lara-Astiaso, Eloisa Jantus-Lewintre, Elizabeth Guruceaga, Shruthi Narayanan, Mariano Ponz-Sarvise, Antonio Pineda-Lucena, Fernando Lecanda, Davide Ruggero, Purvesh Khatri, Enrique Santamaria, Joaquin Fernandez-Irigoyen, Irene Ferrer, Luis Paz-Ares, Matthias Drosten, Mariano Barbacid, Ignacio Gil-Bazo, Silve Vicent
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Drug combinations are key to circumvent resistance mechanisms compromising response to single anti-cancer targeted therapies. The implementation of combinatorial approaches involving MEK1/2 or KRASG12C inhibitors in the context of KRAS-mutat
Externí odkaz:
https://doaj.org/article/e4df0207a07b4df791d9fb4bec0b4c62
Autor:
Adele Francis Xu, Rut Molinuevo, Elisa Fazzari, Harrison Tom, Zijian Zhang, Julien Menendez, Kerriann M Casey, Davide Ruggero, Lindsay Hinck, Jonathan K Pritchard, Maria Barna
Publikováno v:
eLife, Vol 12 (2023)
The formation of paralogs through gene duplication is a core evolutionary process. For paralogs that encode components of protein complexes such as the ribosome, a central question is whether they encode functionally distinct proteins or whether they
Externí odkaz:
https://doaj.org/article/f19b23963865426f832c929b214ae367
Autor:
Honyin Chiu, Roberta Buono, Leandra V. Jackson, Lee-or Herzog, Sharmila Mallya, Crystal S. Conn, Davide Ruggero, David A. Fruman
Publikováno v:
iScience, Vol 24, Iss 7, Pp 102748- (2021)
Summary: The cap-binding protein eukaryotic initiation factor 4E (eIF4E) promotes translation of mRNAs associated with proliferation and survival and is an attractive target for cancer therapeutics. Here, we used Eif4e germline and conditional knocko
Externí odkaz:
https://doaj.org/article/16b020e145ba4a13bce416bb9af9a9f1
Autor:
Duygu Kuzuoglu-Ozturk, Zhiqiang Hu, Martina Rama, Emily Devericks, Jacob Weiss, Gary G. Chiang, Stephen T. Worland, Steven E. Brenner, Hani Goodarzi, Luke A. Gilbert, Davide Ruggero
Publikováno v:
Cell Reports, Vol 35, Iss 13, Pp 109321- (2021)
Summary: The major cap-binding protein eukaryotic translation initiation factor 4E (eIF4E), an ancient protein required for translation of all eukaryotic genomes, is a surprising yet potent oncogenic driver. The genetic interactions that maintain the
Externí odkaz:
https://doaj.org/article/18d631e8c9eb45e2897410bdd7687c18
Autor:
Ryan K. Muir, Ning Zhao, Junnian Wei, Yung-hua Wang, Anna Moroz, Yangjie Huang, Ying-Chu Chen, Renuka Sriram, John Kurhanewicz, Davide Ruggero, Adam R. Renslo, Michael J. Evans
Publikováno v:
ACS Central Science, Vol 5, Iss 4, Pp 727-736 (2019)
Externí odkaz:
https://doaj.org/article/8a1f8dc0392b4f1ca4cc2864af7b7b4e
Autor:
Duygu Kuzuoglu-Ozturk, Ozlem Aksoy, Christin Schmidt, Robin Lea, Jon D. Larson, Ryan R.L. Phelps, Nicole Nasholm, Megan Holt, Adrian Contreras, Miller Huang, Shannon Wong-Michalak, Hao Shao, Robert Wechsler-Reya, Joanna J. Phillips, Jason E. Gestwicki, Davide Ruggero, William A. Weiss
Publikováno v:
Cancer Res
Deregulation of neuroblastoma-derived myc (N-myc) is a leading cause of malignant brain tumors in children. To target N-myc-driven medulloblastoma, most research has focused on identifying genomic alterations or on the analysis of the medulloblastoma
Autor:
Mary McMahon, Adrian Contreras, Mikael Holm, Tamayo Uechi, Craig M Forester, Xiaming Pang, Cody Jackson, Meredith E Calvert, Bin Chen, David A Quigley, John M Luk, R Kate Kelley, John D Gordan, Ryan M Gill, Scott C Blanchard, Davide Ruggero
Publikováno v:
eLife, Vol 8 (2019)
Small nucleolar RNAs (snoRNAs) are a diverse group of non-coding RNAs that direct chemical modifications at specific residues on other RNA molecules, primarily on ribosomal RNA (rRNA). SnoRNAs are altered in several cancers; however, their role in ce
Externí odkaz:
https://doaj.org/article/049984ff3ff540b49c64893eccc6ff9f
Autor:
William A. Weiss, Davide Ruggero, Jason E. Gestwicki, Joanna J. Phillips, Robert Wechsler-Reya, Hao Shao, Shannon Wong-Michalak, Miller Huang, Adrian Contreras, Megan Holt, Nicole Nasholm, Ryan R.L. Phelps, Jon D. Larson, Robin Lea, Christin Schmidt, Ozlem Aksoy, Duygu Kuzuoglu-Ozturk
Translation efficiency in Rapalink-1 and Rapamycin treated samples
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::377742b45975aa50a20cf91cead747f6
https://doi.org/10.1158/0008-5472.22432715
https://doi.org/10.1158/0008-5472.22432715
Autor:
William A. Weiss, Davide Ruggero, Jason E. Gestwicki, Joanna J. Phillips, Robert Wechsler-Reya, Hao Shao, Shannon Wong-Michalak, Miller Huang, Adrian Contreras, Megan Holt, Nicole Nasholm, Ryan R.L. Phelps, Jon D. Larson, Robin Lea, Christin Schmidt, Ozlem Aksoy, Duygu Kuzuoglu-Ozturk
Deregulation of neuroblastoma-derived myc (N-myc) is a leading cause of malignant brain tumors in children. To target N-myc-driven medulloblastoma, most research has focused on identifying genomic alterations or on the analysis of the medulloblastoma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1befd784d6d0f3aafa60a803f1fc6010
https://doi.org/10.1158/0008-5472.c.6514226
https://doi.org/10.1158/0008-5472.c.6514226
Autor:
Michael J. Evans, Jason S. Lewis, Davide Ruggero, Crystal S. Conn, Loc T. Huynh, Matthew F.L. Parker, John T. Cunningham, Charles Truillet
Supplemental Methods, Supplementary Figure 1. A. Real time PCR data showing the suppression of PTEN mRNA levels by an anti PTEN shRNA in GBM and PCa cell lines. The suppression of PTEN mRNA was statistically significant (P < 0.05). B. Immunoblot data
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7922640158fe2775886b7bd81b446ec6
https://doi.org/10.1158/1078-0432.22462844.v1
https://doi.org/10.1158/1078-0432.22462844.v1