Zobrazeno 1 - 10
of 1 025
pro vyhledávání: '"David. C. Montefiori"'
Autor:
Sommer Holmes, Hui Li, Xiaoying Shen, Mitchell Martin, Ryan Tuck, Yue Chen, Elena E. Giorgi, Hélène Fradin Kirshner, Madison Berry, Elizabeth Van Italie, Sravani Venkatayogi, Joshua S. Martin Beem, Robert J. Edwards, Katayoun Mansouri, Ajay Singh, Cindy Kuykendall, Thaddeus Gurley, M. Anthony Moody, Nicole DeNayer, Todd Demarco, Thomas N. Denny, Yunfei Wang, Tyler D. Evangelous, John T. Clinton, Bhavna Hora, Kshitij Wagh, Michael S. Seaman, Kevin O. Saunders, Nicholas Solomotis, Johnathan Misamore, Mark G. Lewis, Kevin Wiehe, David C. Montefiori, George M. Shaw, Wilton B. Williams
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-23 (2024)
Abstract The details of the pediatric immune system that supports induction of antibodies capable of neutralizing geographically-diverse or heterologous HIV-1 is currently unclear. Here we explore the pediatric immune environment in neonatal macaque
Externí odkaz:
https://doaj.org/article/8a02ed03cb6c4c07b1bf35351c55e38c
Autor:
Thanyawee Puthanakit, Eakachai Prompetchara, Sivaporn Gatechompol, Chutitorn Ketloy, Arunee Thitithanyanont, Anan Jongkaewwattana, Supranee Buranapraditkun, Sasiwimol Ubolyam, Stephen J. Kerr, Jiratchaya Sophonphan, Tanakorn Apornpong, Wonngarm Kittanamongkolchai, Sarawut Siwamogsatham, Somchai Sriplienchan, Kanitha Patarakul, Tuangtip Theerawit, Pathariya Promsena, Rapisa Nantanee, Siwaporn Manomaisantiphap, Sarun Chokyakorn, Lina Hong, Mijo Samija, David C. Montefiori, Hongmei Gao, Amanda Eaton, Wassana Wijagkanalan, Mohamad-Gabriel Alameh, Drew Weissman, Kiat Ruxrungtham, ChulaVac001-Phase 2 study team
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract ChulaCov19 mRNA vaccine demonstrated promising phase 1 results. Healthy adults aged 18–59 years were double-blind randomised 4:1 to receive two intramuscular doses of ChulaCov19 50 µg or placebo. Primary endpoints were safety and microneu
Externí odkaz:
https://doaj.org/article/54f54eeb03db4688a4ae18fe00c232c3
Autor:
Stephen R Walsh, Cynthia L Gay, Shelly T Karuna, Ollivier Hyrien, Timothy Skalland, Kenneth H Mayer, Magdalena E Sobieszczyk, Lindsey R Baden, Paul A Goepfert, Carlos Del Rio, Guiseppe Pantaleo, Philip Andrew, Carissa Karg, Zonglin He, Huiyin Lu, Carmen A Paez, Jane A G Baumblatt, Laura L Polakowski, Wairimu Chege, Maija A Anderson, Sophie Janto, Xue Han, Yunda Huang, Julie Dumond, Margaret E Ackerman, Adrian B McDermott, Britta Flach, Estelle Piwowar-Manning, Kelly Seaton, Georgia D Tomaras, David C Montefiori, Lucio Gama, John R Mascola, HVTN 127/HPTN 087 Study Team
Publikováno v:
PLoS Medicine, Vol 21, Iss 6, p e1004329 (2024)
BackgroundBroadly neutralizing antibodies (bnAbs) are a promising approach for HIV-1 prevention. In the Antibody Mediated Prevention (AMP) trials, a CD4-binding site targeting bnAb, VRC01, administered intravenously (IV), demonstrated 75% prevention
Externí odkaz:
https://doaj.org/article/4be70ce338214ab0a34f240e9ededde1
Autor:
Daniel B. Reeves, Bryan T. Mayer, Allan C. deCamp, Yunda Huang, Bo Zhang, Lindsay N. Carpp, Craig A. Magaret, Michal Juraska, Peter B. Gilbert, David C. Montefiori, Katharine J. Bar, E. Fabian Cardozo-Ojeda, Joshua T. Schiffer, Raabya Rossenkhan, Paul Edlefsen, Lynn Morris, Nonhlanhla N. Mkhize, Carolyn Williamson, James I. Mullins, Kelly E. Seaton, Georgia D. Tomaras, Philip Andrew, Nyaradzo Mgodi, Julie E. Ledgerwood, Myron S. Cohen, Lawrence Corey, Logashvari Naidoo, Catherine Orrell, Paul A. Goepfert, Martin Casapia, Magdalena E. Sobieszczyk, Shelly T. Karuna, Srilatha Edupuganti
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract The Antibody Mediated Prevention (AMP) trials (NCT02716675 and NCT02568215) demonstrated that passive administration of the broadly neutralizing monoclonal antibody VRC01 could prevent some HIV-1 acquisition events. Here, we use mathematical
Externí odkaz:
https://doaj.org/article/794805ba580c4e44895b377fd359c2eb
Autor:
Nima S. Hejazi, Xiaoying Shen, Lindsay N. Carpp, David Benkeser, Dean Follmann, Holly E. Janes, Lindsey R. Baden, Hana M. El Sahly, Weiping Deng, Honghong Zhou, Brett Leav, David C. Montefiori, Peter B. Gilbert
Publikováno v:
International Journal of Infectious Diseases, Vol 137, Iss , Pp 28-39 (2023)
Background: Stochastic interventional vaccine efficacy (SVE) analysis is a new approach to correlate of protection (CoP) analysis of a phase III trial that estimates how vaccine efficacy (VE) would change under hypothetical shifts of an immune marker
Externí odkaz:
https://doaj.org/article/148f83696d1243ee863801547dd355e1
Autor:
Ivy Phung, Kristen A. Rodrigues, Ester Marina-Zárate, Laura Maiorino, Bapi Pahar, Wen-Hsin Lee, Mariane Melo, Amitinder Kaur, Carolina Allers, Marissa Fahlberg, Brooke F. Grasperge, Jason P. Dufour, Faith Schiro, Pyone P. Aye, Paul G. Lopez, Jonathan L. Torres, Gabriel Ozorowski, Saman Eskandarzadeh, Michael Kubitz, Erik Georgeson, Bettina Groschel, Rebecca Nedellec, Michael Bick, Katarzyna Kaczmarek Michaels, Hongmei Gao, Xiaoying Shen, Diane G. Carnathan, Guido Silvestri, David C. Montefiori, Andrew B. Ward, Lars Hangartner, Ronald S. Veazey, Dennis R. Burton, William R. Schief, Darrell J. Irvine, Shane Crotty
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Adjuvants and antigen delivery kinetics can profoundly influence B cell responses and should be critically considered in rational vaccine design, particularly for difficult neutralizing antibody targets such as human immunodeficiency virus (
Externí odkaz:
https://doaj.org/article/3d71acce904648df957070b08d1daea9
Autor:
A. Brenda Kapingidza, Daniel J. Marston, Caitlin Harris, Daniel Wrapp, Kaitlyn Winters, Dieter Mielke, Lu Xiaozhi, Qi Yin, Andrew Foulger, Rob Parks, Maggie Barr, Amanda Newman, Alexandra Schäfer, Amanda Eaton, Justine Mae Flores, Austin Harner, Nicholas J. Catanzaro, Michael L. Mallory, Melissa D. Mattocks, Christopher Beverly, Brianna Rhodes, Katayoun Mansouri, Elizabeth Van Itallie, Pranay Vure, Brooke Dunn, Taylor Keyes, Sherry Stanfield-Oakley, Christopher W. Woods, Elizabeth A. Petzold, Emmanuel B. Walter, Kevin Wiehe, Robert J. Edwards, David C. Montefiori, Guido Ferrari, Ralph Baric, Derek W. Cain, Kevin O. Saunders, Barton F. Haynes, Mihai L. Azoitei
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Immune responses to SARS-CoV-2 primarily target the receptor binding domain of the spike protein, which continually mutates to escape acquired immunity. Other regions in the spike S2 subunit, such as the stem helix and the segment encompassi
Externí odkaz:
https://doaj.org/article/f7c3c671d32d475aacf1c3a48887812f
Autor:
Spyros Chalkias, Charles Harper, Keith Vrbicky, Stephen R. Walsh, Brandon Essink, Adam Brosz, Nichole McGhee, Joanne E. Tomassini, Xing Chen, Ying Chang, Andrea Sutherland, David C. Montefiori, Bethany Girard, Darin K. Edwards, Jing Feng, Honghong Zhou, Lindsey R. Baden, Jacqueline M. Miller, Rituparna Das
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-7 (2023)
Abstract We previously presented day 29 interim safety and immunogenicity results from a phase 2/3 study (NCT04927065) comparing the Omicron-BA.1-containing bivalent vaccine mRNA-1273.214 (50-µg) to the 50-µg mRNA-1273 booster in adults who previou
Externí odkaz:
https://doaj.org/article/1a6753255d44434c95bc9554b61b13a6
Autor:
Kirsten E. Lyke, Robert L. Atmar, Clara Dominguez Islas, Christine M. Posavad, Meagan E. Deming, Angela R. Branche, Christine Johnston, Hana M. El Sahly, Srilatha Edupuganti, Mark J. Mulligan, Lisa A. Jackson, Richard E. Rupp, Christina A. Rostad, Rhea N. Coler, Martín Bäcker, Angelica C. Kottkamp, Tara M. Babu, David Dobrzynski, Judith M. Martin, Rebecca C. Brady, Robert W. Frenck, Kumaravel Rajakumar, Karen Kotloff, Nadine Rouphael, Daniel Szydlo, Rahul PaulChoudhury, Janet I. Archer, Sonja Crandon, Brian Ingersoll, Amanda Eaton, Elizabeth R. Brown, M. Juliana McElrath, Kathleen M. Neuzil, David S. Stephens, Diane J. Post, Bob C. Lin, Leonid Serebryannyy, John H. Beigel, David C. Montefiori, Paul C. Roberts, the DMID 21-0012 Study Group
Publikováno v:
npj Vaccines, Vol 8, Iss 1, Pp 1-10 (2023)
Abstract As part of a multicenter study evaluating homologous and heterologous COVID-19 booster vaccines, we assessed the magnitude, breadth, and short-term durability of binding and pseudovirus-neutralizing antibody (PsVNA) responses following a sin
Externí odkaz:
https://doaj.org/article/25f04fdb644f4573b07bd819954db49f
Autor:
Daniel B. Reeves, Bryan T. Mayer, Allan C. deCamp, Yunda Huang, Bo Zhang, Lindsay N. Carpp, Craig A. Magaret, Michal Juraska, Peter B. Gilbert, David C. Montefiori, Katharine J. Bar, E. Fabian Cardozo-Ojeda, Joshua T. Schiffer, Raabya Rossenkhan, Paul Edlefsen, Lynn Morris, Nonhlanhla N. Mkhize, Carolyn Williamson, James I. Mullins, Kelly E. Seaton, Georgia D. Tomaras, Philip Andrew, Nyaradzo Mgodi, Julie E. Ledgerwood, Myron S. Cohen, Lawrence Corey, Logashvari Naidoo, Catherine Orrell, Paul A. Goepfert, Martin Casapia, Magdalena E. Sobieszczyk, Shelly T. Karuna, Srilatha Edupuganti
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-2 (2024)
Externí odkaz:
https://doaj.org/article/ef191c52261c47488786020343882bd3