Zobrazeno 1 - 10 of 348 pro vyhledávání: '"David-J Chen"'
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Supplementary Figure 1 from Threonine 2609 Phosphorylation of the DNA-Dependent Protein Kinase Is a Critical Prerequisite for Epidermal Growth Factor Receptor–Mediated Radiation Resistance
Autor: Chaitanya S. Nirodi, Benjamin P. Chen, David J. Chen, Yu-Fen Lin, Amit K. Das, Haruhiko Makino, Prashanthi Javvadi
PDF file - 286K, Alterations in ATM or DNA-PKcs do not affect IR-induced nuclear import. Deficiency or inhibition of either ATM or DNA-PKcs is associated with an absence of EGFR-DNA-PKcs binding. The data in S1A eliminate the possibility that this is
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bd2ec8d71b368712aaa34a9053ba0aa
https://doi.org/10.1158/1541-7786.22516564.v1
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Data from Threonine 2609 Phosphorylation of the DNA-Dependent Protein Kinase Is a Critical Prerequisite for Epidermal Growth Factor Receptor–Mediated Radiation Resistance
Autor: Chaitanya S. Nirodi, Benjamin P. Chen, David J. Chen, Yu-Fen Lin, Amit K. Das, Haruhiko Makino, Prashanthi Javvadi
The EGF receptor (EGFR) contributes to tumor radioresistance, in part, through interactions with the catalytic subunit of DNA-dependent protein kinase (DNA-PKc), a key enzyme in the nonhomologous end joining DNA repair pathway. We previously showed t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cc52d25d039202f5eb52fe8be9a40fa
https://doi.org/10.1158/1541-7786.c.6541408
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Supplementary Figure 4 from Threonine 2609 Phosphorylation of the DNA-Dependent Protein Kinase Is a Critical Prerequisite for Epidermal Growth Factor Receptor–Mediated Radiation Resistance
Autor: Chaitanya S. Nirodi, Benjamin P. Chen, David J. Chen, Yu-Fen Lin, Amit K. Das, Haruhiko Makino, Prashanthi Javvadi
PDF file - 607K, Effect of EGFR mutation status on DNA-Pkcs phosphorylation. Immuno-fluorescence detection of DNA-PKcs phosphorylation in HBEC cells stably expressing wild type, L858R or gammaE746-E750 forms of EGFR at various time-points following 4
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c43d1bdec48e55ab607928651fd966c
https://doi.org/10.1158/1541-7786.22516555.v1
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Supplementary Figure 2 from Threonine 2609 Phosphorylation of the DNA-Dependent Protein Kinase Is a Critical Prerequisite for Epidermal Growth Factor Receptor–Mediated Radiation Resistance
Autor: Chaitanya S. Nirodi, Benjamin P. Chen, David J. Chen, Yu-Fen Lin, Amit K. Das, Haruhiko Makino, Prashanthi Javvadi
PDF file - 544K, Proximity ligation assay (PLA): Effect of DNA-Pkcs and ATM inhibition on EGFR-DNA-PKcs binding.NSCLCs or HBEC-3KT cells expressing wild type or gammaE746-E750 forms of EGFR following a 2 h pretreatment with vehicle, 10 muM NU7441 or
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13876bd423b4c02d72069477eb5eaeb3
https://doi.org/10.1158/1541-7786.22516561
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Supplementary Figure 7 from Threonine 2609 Phosphorylation of the DNA-Dependent Protein Kinase Is a Critical Prerequisite for Epidermal Growth Factor Receptor–Mediated Radiation Resistance
Autor: Chaitanya S. Nirodi, Benjamin P. Chen, David J. Chen, Yu-Fen Lin, Amit K. Das, Haruhiko Makino, Prashanthi Javvadi
PDF file - 774K, Proximity ligation assay (PLA): To detect radiation-induced PP2A-DNA-PKcs binding. NSCLCs and HBEC cells expressing WT or gammaE746-E750 EGFR fixed 1 h following 0 Gy or 4 Gy IR. Left panel: representative images of nuclei (blue) and
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73d8c314280ff74da95680be3cb878db
https://doi.org/10.1158/1541-7786.22516546
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Supplementary Figure 3 from Threonine 2609 Phosphorylation of the DNA-Dependent Protein Kinase Is a Critical Prerequisite for Epidermal Growth Factor Receptor–Mediated Radiation Resistance
Autor: Chaitanya S. Nirodi, Benjamin P. Chen, David J. Chen, Yu-Fen Lin, Amit K. Das, Haruhiko Makino, Prashanthi Javvadi
PDF file - 729K, Proximity ligation assay (PLA): Effect of T2609A and S2056A on EGFR-DNA-PKcs binding. V3-WT DNA-PKCS, V3-S2056A and V3-T2609A CHO cells expressing wild type EGFR which were either mock-irradiated or exposed to 4 Gy IR. Left panel: re
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0873321272ae884149cca8abe62f13ef
https://doi.org/10.1158/1541-7786.22516558.v1
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