Zobrazeno 1 - 10
of 119
pro vyhledávání: '"David-Axel Laplaud"'
Autor:
Léo Boussamet, Emmanuel Montassier, Camille Mathé, Alexandra Garcia, Jérémy Morille, Sita Shah, Emilie Dugast, Sandrine Wiertlewski, Mathilde Gourdel, Corinna Bang, Klarissa H. Stürner, Damien Masson, Arnaud B. Nicot, Nicolas Vince, David-Axel Laplaud, Douglas L. Feinstein, Laureline Berthelot
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract In multiple sclerosis (MS), alterations of the gut microbiota lead to inflammation. However, the role of other microbiomes in the body in MS has not been fully elucidated. In a pilot case-controlled study, we carried out simultaneous charact
Externí odkaz:
https://doaj.org/article/3a2480fe89db4b468ef3d25f535d1784
Autor:
Chadia Ed‐driouch, Florent Chéneau, Françoise Simon, Guillaume Pasquier, Benoit Combès, Anne Kerbrat, Emmanuelle Le Page, Sophie Limou, Nicolas Vince, David‐Axel Laplaud, Franck Mars, Cédric Dumas, Gilles Edan, Pierre‐Antoine Gourraud
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 9, Iss 12, Pp 1863-1873 (2022)
Abstract Objective Multiple sclerosis (MS) is a multifactorial disease with increasingly complicated management. Our objective is to use on‐demand computational power to address the challenges of dynamically managing MS. Methods A phase 3 clinical
Externí odkaz:
https://doaj.org/article/3aa3aa89d1a642b69c94ddff9b8613b1
Autor:
Sarah Wilson, Floriane Calocer, Fabien Rollot, Mathieu Fauvernier, Laurent Remontet, Laure Tron, Sandra Vukusic, Emmanuelle Le Page, Marc Debouverie, Jonathan Ciron, Aurélie Ruet, Jérôme De Sèze, Hélène Zephir, Thibault Moreau, Christine Lebrun-Frénay, David-Axel Laplaud, Pierre Clavelou, Pierre Labauge, Eric Berger, Jean Pelletier, Olivier Heinzlef, Eric Thouvenot, Jean Philippe Camdessanché, Emmanuelle Leray, Olivier Dejardin, Gilles Defer
Publikováno v:
The Lancet Regional Health. Europe, Vol 24, Iss , Pp 100542- (2023)
Summary: Background: The effects of socio-economic status on mortality in patients with multiple sclerosis is not well known. The objective was to examine mortality due to multiple sclerosis according to socio-economic status. Methods: A retrospectiv
Externí odkaz:
https://doaj.org/article/ed163a351a914b918dd49d51d455ef33
Autor:
Catharina C. Gross, Céline Meyer, Urvashi Bhatia, Lidia Yshii, Ilka Kleffner, Jan Bauer, Anna R. Tröscher, Andreas Schulte-Mecklenbeck, Sebastian Herich, Tilman Schneider-Hohendorf, Henrike Plate, Tanja Kuhlmann, Markus Schwaninger, Wolfgang Brück, Marc Pawlitzki, David-Axel Laplaud, Delphine Loussouarn, John Parratt, Michael Barnett, Michael E. Buckland, Todd A. Hardy, Stephen W. Reddel, Marius Ringelstein, Jan Dörr, Brigitte Wildemann, Markus Kraemer, Hans Lassmann, Romana Höftberger, Eduardo Beltrán, Klaus Dornmair, Nicholas Schwab, Luisa Klotz, Sven G. Meuth, Guillaume Martin-Blondel, Heinz Wiendl, Roland Liblau
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-19 (2019)
Susac syndrome is an inflammatory pathology of the brain endothelium. Here the authors show that the pathology is driven by CD8 T cells attacking the endothelium, and that blocking T cell-endothelial adhesion ameliorates the disease in a mouse model,
Externí odkaz:
https://doaj.org/article/4c98395f104445a7a39848447428e6cc
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 20, p 12142 (2022)
Multiple sclerosis is a chronic and inflammatory disease of the central nervous system. Although this disease is widely studied, many of the precise mechanisms involved are still not well known. Numerous studies currently focusing on multiple scleros
Externí odkaz:
https://doaj.org/article/4dff63d2eddf46d99dc1dd392d3b4a16
Autor:
Sylvain Perriot, Amandine Mathias, Guillaume Perriard, Mathieu Canales, Nils Jonkmans, Nicolas Merienne, Cécile Meunier, Lina El Kassar, Anselme L. Perrier, David-Axel Laplaud, Myriam Schluep, Nicole Déglon, Renaud Du Pasquier
Publikováno v:
Stem Cell Reports, Vol 11, Iss 5, Pp 1199-1210 (2018)
Summary: Recent studies highlighted the importance of astrocytes in neuroinflammatory diseases, interacting closely with other CNS cells but also with the immune system. However, due to the difficulty in obtaining human astrocytes, their role in thes
Externí odkaz:
https://doaj.org/article/4835770e4d1c4fb88ad494f4e27a421a
Autor:
Gaëlle Tilly, Tra-My Doan-Ngoc, Michelle Yap, Aurélie Caristan, Lola Jacquemont, Richard Danger, Marion Cadoux, Sarah Bruneau, Magali Giral, Pierrick Guerif, Bryan Nicol, Alexandra Garcia, David-Axel Laplaud, Sophie Brouard, Claire Pecqueur Hellman, Nicolas Degauque
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
The involvement of TEMRA CD8 is evident in a large array of immunological conditions ranging from auto- to allo-immunity. Nevertheless, the factors leading to their accumulation and activation remain ill-defined and, efficient therapeutics to control
Externí odkaz:
https://doaj.org/article/3e5ec2a0a6b9412c97445fa95fb1fd17
Autor:
Annie Elong Ngono, Maud Lepetit, Markus Reindl, Alexandra Garcia, Flora Guillot, Athénaïs Genty, Mélanie Chesneau, Marion Salou, Laure Michel, Fabienne Lefrere, Kathrin Schanda, Berthe-Marie Imbert-Marcille, Nicolas Degauque, Arnaud Nicot, Sophie Brouard, David-Axel Laplaud, Jean-Paul Soulillou
Publikováno v:
Journal of Immunology Research, Vol 2015 (2015)
Although there is no evidence for a role of anti-MOG antibodies in adult MS, no information on B lymphocytes with MOG-committed BCR is available. We report here on the frequency of anti-MOG B cells forming rosettes with polystyrene beads (BBR) covale
Externí odkaz:
https://doaj.org/article/6ae697d266744128b8d799aebc99bf4b
Autor:
Camille Sabathé, Romain Casey, Sandra Vukusic, Emmanuelle Leray, Guillaume Mathey, Jérôme De Sèze, Jonathan Ciron, Sandrine Wiertlewski, Aurélie Ruet, Jean Pelletier, Hélène Zéphir, Laure Michel, Christine Lebrun-Frenay, Xavier Moisset, Eric Thouvenot, Jean-Philippe Camdessanché, Serge Bakchine, Bruno Stankoff, Abdullatif Al Khedr, Philippe Cabre, Elisabeth Maillart, Eric Berger, Olivier Heinzlef, Karolina Hankiewicz, Thibault Moreau, Olivier Gout, Bertrand Bourre, Abir Wahab, Pierre Labauge, Alexis Montcuquet, Gilles Defer, Aude Maurousset, Nicolas Maubeuge, Dalia Dimitri Boulos, Haïfa Ben Nasr, Chantal Nifle, Olivier Casez, David-Axel Laplaud, Yohann Foucher
Publikováno v:
Multiple Sclerosis Journal
Multiple Sclerosis Journal, 2023, 29 (2), pp.236-247. ⟨10.1177/13524585221139156⟩
Multiple Sclerosis Journal, 2023, 29 (2), pp.236-247. ⟨10.1177/13524585221139156⟩
Background: In relapsing-remitting multiple sclerosis (RRMS), early identification of suboptimal responders can prevent disability progression. Objective: We aimed to develop and validate a dynamic score to guide the early decision to switch from fir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb0d295f009630c7a4453984a4cacd15
https://amu.hal.science/hal-04086418
https://amu.hal.science/hal-04086418
Autor:
Arnaud B Nicot, Jean Harb, Alexandra Garcia, Flora Guillot, Hoa-Le Mai, Camille V Mathé, Jérémy Morille, Amélie Vallino, Emilie Dugast, Sita P Shah, Fabienne Lefrère, Mélinda Moyon, Sandrine Wiertlewski, Ludmilla Le Berre, Karine Renaudin, Jean-Paul Soulillou, Vincent van Pesch, Sophie Brouard, Laureline Berthelot, David-Axel Laplaud
Publikováno v:
Brain communications, Vol. 5, no.2, p. fcad044 (2023)
Multiple sclerosis is an autoimmune disease of the central nervous system. Yet, the autoimmune targets are still undefined. The extracellular e1 sequence of KCNJ10, the inwardly rectifying potassium channel 4.1, has been subject to fierce debate for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b08e80e2d7a198dceb59d43776d6022
https://hdl.handle.net/2078.1/276387
https://hdl.handle.net/2078.1/276387