Zobrazeno 1 - 10
of 39
pro vyhledávání: '"David von Schack"'
Autor:
Chirag Krishna, Joshua Chiou, Saori Sakaue, Joyce B. Kang, Stephen M. Christensen, Isac Lee, Melis Atalar Aksit, Hye In Kim, David von Schack, Soumya Raychaudhuri, Daniel Ziemek, Xinli Hu
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Genetic variation in the human leukocyte antigen (HLA) loci is associated with risk of immune-mediated diseases, but the molecular effects of HLA polymorphism are unclear. Here we examined the effects of HLA genetic variation on the expressi
Externí odkaz:
https://doaj.org/article/68deecd756d04f759f1d94d794e8cfa3
Autor:
Emma E. Davenport, Tiffany Amariuta, Maria Gutierrez-Arcelus, Kamil Slowikowski, Harm-Jan Westra, Yang Luo, Ciyue Shen, Deepak A. Rao, Ying Zhang, Stephen Pearson, David von Schack, Jean S. Beebe, Nan Bing, Sally John, Michael S. Vincent, Baohong Zhang, Soumya Raychaudhuri
Publikováno v:
Genome Biology, Vol 19, Iss 1, Pp 1-15 (2018)
Abstract Background Cytokines are critical to human disease and are attractive therapeutic targets given their widespread influence on gene regulation and transcription. Defining the downstream regulatory mechanisms influenced by cytokines is central
Externí odkaz:
https://doaj.org/article/8075e72d26c1477fb0d4a12d32759788
Autor:
Ankur Sharma, Christine Huard, Cecile Vernochet, Daniel Ziemek, Kelly M Knowlton, Edyta Tyminski, Theresa Paradis, Ying Zhang, Jessica E C Jones, David von Schack, Christopher T Brown, Patrice M Milos, Anthony J Coyle, Frederic Tremblay, Robert V Martinez
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e92608 (2014)
Brown adipose tissue (BAT) plays a pivotal role in promoting energy expenditure by the virtue of uncoupling protein-1 (UCP-1) that differentiates BAT from its energy storing white adipose tissue (WAT) counterpart. The clinical implication of "classic
Externí odkaz:
https://doaj.org/article/35e422420472415ea5da98951dbe7a46
Autor:
David von Schack, Michael J Agostino, B Stuart Murray, Yizheng Li, Padmalatha S Reddy, Jin Chen, Sung E Choe, Brian W Strassle, Christine Li, Brian Bates, Lynn Zhang, Huijuan Hu, Smita Kotnis, Brendan Bingham, Wei Liu, Garth T Whiteside, Tarek A Samad, Jeffrey D Kennedy, Seena K Ajit
Publikováno v:
PLoS ONE, Vol 6, Iss 3, p e17670 (2011)
Neuropathic pain resulting from nerve lesions or dysfunction represents one of the most challenging neurological diseases to treat. A better understanding of the molecular mechanisms responsible for causing these maladaptive responses can help develo
Externí odkaz:
https://doaj.org/article/eb2ca94931af404d80273a0111199401
Autor:
Mina Hassan-Zahraee, Michael S. Vincent, Julie Lee, Mateusz Maciejewski, Vivek Pradhan, Shanrong Zhao, Yutian Zhan, David von Schack, Huanyu Zhou, Kenneth J. Gorelick, Zachary S. Stewart, Lori Fitz, Shawn P. O'Neil, Ying Zhang, Austin Huang, Li Xi, Karen Page, Kenneth E. Hung, Daniel Ziemek, Fabio Cataldi, Baohong Zhang
Publikováno v:
Journal of Crohn's & Colitis
Background and Aims To define pharmacodynamic and efficacy biomarkers in ulcerative colitis [UC] patients treated with PF-00547659, an anti-human mucosal addressin cell adhesion molecule-1 [MAdCAM-1] monoclonal antibody, in the TURANDOT study. Method
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
Scientific Reports
Scientific Reports
To allow efficient transcript/gene detection, highly abundant ribosomal RNAs (rRNA) are generally removed from total RNA either by positive polyA+ selection or by rRNA depletion (negative selection) before sequencing. Comparisons between the two meth
Autor:
Steven W. Martin, Hendrik Neubert, David von Schack, Padma Reddy, Fabio Cataldi, Mina Hassan-Zahraee, John B. Cheng, Clare Robert A, Kenneth E. Hung, Karen Page, Baohong Zhang, Alaa Ahmad, Satyaprakash Nayak, Anindita Banerjee, Ken Gorelick, Mireia Fernández Ocaña, Li Xi, Michael S. Vincent, Weidong Zhang
Publikováno v:
Journal of Crohn's & Colitis
Objective To define pharmacodynamic biomarkers in the peripheral blood of patients with Crohn’s disease [CD] after treatment with PF-00547659, an anti-human mucosal addressin cell adhesion molecule-1 [MAdCAM-1] monoclonal antibody. Methods In this
Autor:
David von Schack, Angela Hadjipanayis, Weidong Zhang, Mateusz Maciejewski, Xing Chen, Daniel Ziemek, Julie Lee, Lori Fitz, David Martin, Shanrong Zhao, Craig L. Hyde
Publikováno v:
Poster Presentations.
Background The Janus kinase (JAK) family of tyrosine kinases includes JAK1, JAK2, JAK3 and TYK2 which signals through type I and type II cytokine receptors. Tofacitinib is an oral JAK inhibitor approved for the treatment of rheumatoid arthritis (RA).
Autor:
Inga D. Neumann, Benjamin Jurek, David A. Slattery, Carl-Philipp Meinung, Stefanie Martinetz, Erwin H. van den Burg, David von Schack
Publikováno v:
Biological psychiatry. 85(10)
Background The neuropeptide oxytocin (OXT) mediates its actions, including anxiolysis, via its G protein–coupled OXT receptor. Within the paraventricular nucleus of the hypothalamus (PVN), OXT-induced anxiolysis is mediated, at least in part, via a
Autor:
Sally John, Jean S. Beebe, David von Schack, Tiffany Amariuta, Ciyue Shen, Maria Gutierrez-Arcelus, Nan Bing, Deepak A. Rao, Michael S. Vincent, Baohong Zhang, Harm-Jan Westra, Ying Zhang, Emma E. Davenport, Kamil Slowikowski, Stephen Pearson, Yang Luo, Soumya Raychaudhuri
Publikováno v:
Davenport, E E, Amariuta, T, Gutierrez-arcelus, M, Slowikowski, K, Westra, H, Luo, Y, Shen, C, Rao, D A, Zhang, Y, Pearson, S, Von Schack, D, Beebe, J S, Bing, N, John, S, Vincent, M S, Zhang, B & Raychaudhuri, S 2018, ' Discovering in vivo cytokine-eQTL interactions from a lupus clinical trial ', Genome biology, vol. 19, no. 1 . https://doi.org/10.1186/s13059-018-1560-8
Genome Biology
Genome Biology, Vol 19, Iss 1, Pp 1-15 (2018)
Genome Biology
Genome Biology, Vol 19, Iss 1, Pp 1-15 (2018)
Background Cytokines are critical to human disease and are attractive therapeutic targets given their widespread influence on gene regulation and transcription. Defining the downstream regulatory mechanisms influenced by cytokines is central to defin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2d95ac5b5774472f54f1bdea0a523b9
https://www.research.manchester.ac.uk/portal/en/publications/discovering-in-vivo-cytokineeqtl-interactions-from-a-lupus-clinical-trial(74f69374-3729-4e2a-a9a7-a95464cb67e8).html
https://www.research.manchester.ac.uk/portal/en/publications/discovering-in-vivo-cytokineeqtl-interactions-from-a-lupus-clinical-trial(74f69374-3729-4e2a-a9a7-a95464cb67e8).html