Zobrazeno 1 - 5
of 5
pro vyhledávání: '"David Zollman"'
Autor:
Alena Kroupova, Valentina A. Spiteri, Zoe J. Rutter, Hirotake Furihata, Darren Darren, Sarath Ramachandran, Sohini Chakraborti, Kevin Haubrich, Julie Pethe, Denzel Gonzales, Andre J. Wijaya, Maria Rodriguez-Rios, Manon Sturbaut, Dylan M. Lynch, William Farnaby, Mark A. Nakasone, David Zollman, Alessio Ciulli
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract The ubiquitin E3 ligase cereblon (CRBN) is the target of therapeutic drugs thalidomide and lenalidomide and is recruited by most targeted protein degraders (PROTACs and molecular glues) in clinical development. Biophysical and structural inv
Externí odkaz:
https://doaj.org/article/70479f877d614c148e6f8203f19d4b2d
Autor:
David Zollman, Alessio Ciulli
Publikováno v:
Protein Degradation with New Chemical Modalities ISBN: 9781788016865
Small-molecule degraders are a revolutionary modality of pharmacological intervention in chemical biology and drug discovery. Instead of inhibiting protein targets, molecules that induce rapid, profound and selective degradation of targeted proteins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::873589e24ad80ee12494d392e286497d
https://doi.org/10.1039/9781839160691-00014
https://doi.org/10.1039/9781839160691-00014
Autor:
Simon Wöhrle, Tom Owen-Hughes, Jale Karolyi-Oezguer, Teresa Gmaschitz, Steffen Steurer, Bernadette Sharps, Heribert Arnhof, Gerd Bader, Joerg Rinnenthal, Thomas Gerstberger, Peter Greb, Manfred Koegl, Johannes Wachter, Michael Galant, Klaus Rumpel, Carina Riedmueller, William Farnaby, David Zollman, Peter Ettmayer, Meng-Ying Wu, Michael J. Roy, Emelyne Diers, Andreas Zoephel, Nicole Trainor, Darryl B. McConnell, Nicola Wiechens, Mark Pearson, Guido Boehmelt, Oliver Petermann, Alessio Ciulli, Renate Schnitzer, Harald Weinstabl, Christian Dank, Katharina Ehrenhöfer-Wölfer, Alexander Weiss-Puxbaum, Claire Whitworth, Elisabeth Traxler
Publikováno v:
Nature chemical biology
Targeting subunits of BAF/PBAF chromatin remodeling complexes has been proposed as an approach to exploit cancer vulnerabilities. Here, we develop proteolysis targeting chimera (PROTAC) degraders of the BAF ATPase subunits SMARCA2 and SMARCA4 using a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec7294dabd3aa7131694badb1e13fb5c
https://pubmed.ncbi.nlm.nih.gov/31267096
https://pubmed.ncbi.nlm.nih.gov/31267096
Autor:
Jale Karolyi-Oezguer, Renate Schnitzer, Heribert Arnhof, Emelyne Diers, Andreas Zoephel, Harald Weinstabl, Bernadette Sharps, Darryl B. McConnell, Katharina Ehrenhöfer-Wölfer, Peter Ettmayer, David Zollman, Joerg Rinnenthal, Guido Boehmelt, Michael J. Roy, Meng-Ying Wu, Alessio Ciulli, Thomas Gerstberger, Klaus Rumpel, William Farnaby, Carina Riedmueller, Alexander Weiss-Puxbaum, Nicole Trainor, Peter Greb, Mark Pearson, Johannes Wachter, Michael Galant, Steffen Steurer, Tom Owen-Hughes, Oliver Petermann, Simon Wöhrle, Manfred Koegl, Nicola Wiechens, Elisabeth Traxler, Gerd Bader, Teresa Gmaschitz, Christian Dank, Claire Whitworth
Publikováno v:
Nature Chemical Biology. 15:846-846
In the version of this article originally published, several lines of text in the last paragraph of the right column on page 1 of the PDF were transposed into the bottom paragraph of the left column. The affected text of the left column should read "
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f7486b9d8ad9fe9437d9ccce229082c6
https://doi.org/10.1038/s41589-019-0329-z
https://doi.org/10.1038/s41589-019-0329-z
Autor:
Jürgen, Brem, Sander S, van Berkel, David, Zollman, Sook Y, Lee, Opher, Gileadi, Peter J, McHugh, Timothy R, Walsh, Michael A, McDonough, Christopher J, Schofield
Publikováno v:
Antimicrobial Agents and Chemotherapy
β-Lactams are the most successful antibacterials, but their effectiveness is threatened by resistance, most importantly by production of serine- and metallo-β-lactamases (MBLs). MBLs are of increasing concern because they catalyze the hydrolysis of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::805d7ffdcf541c3ab1d3e9a3fbb7b195
https://pubmed.ncbi.nlm.nih.gov/26482303
https://pubmed.ncbi.nlm.nih.gov/26482303