Zobrazeno 1 - 10
of 42
pro vyhledávání: '"David Y. Jackson"'
Autor:
Hai Li, Andrew Luo, Steven J. Chapin, Shelley Erin Ackerman, Marcin Kowanetz, Michael N. Alonso, Po Y. Ho, Arthur Lee, Karla Henning, Samuel C. Kimmey, Benjamin Ackerman, Joshua D. Gregorio, Brian Safina, Vishnu C. Ramani, David Dornan, Lauren Y. Sheu, Jennifer Melrose, Cecelia Pearson, Richard P. Laura, Bruce H. Devens, Justin A. Kenkel, Edgar G. Engleman, Lisa Blum, David Y. Jackson, Heidi N. Leblanc, Joseph C. Gonzalez, Grant Yonehiro, Yaron Carmi, Felix J. Hartmann, Sean C. Bendall, Murray L. Nguyen, Angela Luo, Jason C. Paik
Publikováno v:
Nat Cancer
Innate pattern recognition receptor agonists, including Toll-like receptors (TLRs), alter the tumor microenvironment and prime adaptive antitumor immunity. However, TLR agonists present toxicities associated with widespread immune activation after sy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::436acc59b100dcb9f23295f5a324b4fb
https://europepmc.org/articles/PMC9012298/
https://europepmc.org/articles/PMC9012298/
Autor:
Andrew Luo, Joseph C. Gonzalez, Richard P. Laura, Michael N. Alonso, Samuel C. Kimmey, David Y. Jackson, Shelley Erin Ackerman, David Dornan, Benjamin Ackerman, Edgar G. Engleman, Po Yi Ho, Felix J. Hartmann, Bruce H. Devens, Jason C. Paik, Sean C. Bendall, Arthur Lee, Steven J. Chapin, Cecelia Pearson, Karla Henning
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Background Immune stimulating antibody conjugates (ISACs) covalently attach TLR7/8 immune stimulants to tumor-targeting antibodies. ISACs can be delivered systemically and act locally in the tumor microenvironment by requiring the following biologica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18731c6e9988ac6872dda1adb861d3c2
https://doaj.org/article/f5d7558c062d476da010b826729b37c4
https://doaj.org/article/f5d7558c062d476da010b826729b37c4
Autor:
David Y. Jackson
Publikováno v:
Organic Process Research & Development. 20:852-866
Antibody drug conjugates (ADCs) are synthesized by conjugating a cytotoxic drug or “payload” to a monoclonal antibody. The payloads are conjugated using amino or sulfhydryl specific linkers that react with lysines or cysteines on the antibody sur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d53e4cfa65a5690d1637a3d293d56551
https://doi.org/10.1021/acs.oprd.6b00067
https://doi.org/10.1021/acs.oprd.6b00067
Autor:
Randall L. Halcomb, Amanda Valdiosera, David Y. Jackson, Lawrence Chinn, Jonathan S. Melnick, Migone Thi Sau, Mark R. Flory, Derrick Houser, Edward H. van der Horst, Maureen Fitch-Bruhns, Simeon Bowers, Edward Ha, Jorge Monteon, Jan Willem Theunissen, Gary Probst, Tiffany Wong, Paul W. Sauer, Zoia Levashova, Kristy Venstrom, Abel Bermudez, Sindy Liao-Chan, Christopher R. Behrens
Publikováno v:
Mol Pharm
Conventional antibody–drug conjugates (ADCs) are heterogeneous mixtures of chemically distinct molecules that vary in both drugs/antibody (DAR) and conjugation sites. Suboptimal properties of heterogeneous ADCs have led to new site-specific conjuga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d883318e923b6b79e4a53f04cf24bb2c
https://doi.org/10.1021/acs.molpharmaceut.5b00432
https://doi.org/10.1021/acs.molpharmaceut.5b00432
Autor:
David Y. Jackson
Publikováno v:
ChemInform. 47
Antibody drug conjugates (ADCs) are synthesized by conjugating a cytotoxic drug or “payload” to a monoclonal antibody. The payloads are conjugated using amino or sulfhydryl specific linkers that react with lysines or cysteines on the antibody sur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::70733dbdc7fb8139ccbea5db5b44e55e
https://doi.org/10.1002/chin.201628291
https://doi.org/10.1002/chin.201628291
Publikováno v:
International Journal of Peptide and Protein Research. 31:388-395
The synthesis and characterization of monofluoroacetyl (MFAc) functionalized haptens are described. These were covalently bound to polypeptide carriers (bovine serum albumin and poly-D-lysine) by primary amine/succinimide ester or primary amine/acid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dcf0cb6a7617116b097c42264926ec6
https://doi.org/10.1111/j.1399-3011.1988.tb00047.x
https://doi.org/10.1111/j.1399-3011.1988.tb00047.x
Publikováno v:
Autonomic Neuroscience. 122:58-68
Sympathetic neurons extend and maintain axons that innervate the myocardium, and proper innervation is important for cardiac function. However, the molecular basis for axon outgrowth and maintenance is not well understood. We have shown previously th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29f3f3850f48bdcd8ecb984c2b4b9c73
https://doi.org/10.1016/j.autneu.2005.08.006
https://doi.org/10.1016/j.autneu.2005.08.006
Autor:
Sherry T. Hikita, Lisa Kinney, Susan A.L. Jacques, Erin C. Tolhurst, Kevin L. Wingerd, Sergiu T. Leu, Derek Wiswell, Dennis O. Clegg, Nichol L. Goodman, Jan L. Pring, David Y. Jackson
Publikováno v:
Developmental Biology. 276:416-430
In the retina, integrins in the beta1 family have been shown to be important in many phases of neuronal development, particularly neuroblast migration and axon outgrowth. However, the functions of specific integrin heterodimers are not well defined.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b61687f1ce9e00ffa9a017ac1030370
https://doi.org/10.1016/j.ydbio.2004.09.003
https://doi.org/10.1016/j.ydbio.2004.09.003
Autor:
Jan L. Pring, David Y. Jackson, Jason Tresser, Kevin L. Wingerd, Steven J. Rohan, Nichol L. Goodman, Matthew M. Smail, Sergiu T. Leu, Dennis O. Clegg
Publikováno v:
The Journal of Neuroscience. 22:10772-10780
Sympathetic neurons innervate the heart early in postnatal development, an event that is crucial for proper modulation of blood pressure and cardiac function. However, the axon guidance cues that direct sympathetic neurons to the heart, and the neuro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fde7b7714e3f219da89c3933ca899570
https://doi.org/10.1523/jneurosci.22-24-10772.2002
https://doi.org/10.1523/jneurosci.22-24-10772.2002