Zobrazeno 1 - 10
of 108
pro vyhledávání: '"David Y. Gin"'
Autor:
Marta Gómez-Nuñez, Kurtis J Haro, Tao Dao, Deming Chau, Annie Won, Sindy Escobar-Alvarez, Victoriya Zakhaleva, Tatyana Korontsvit, David Y Gin, David A Scheinberg
Publikováno v:
PLoS ONE, Vol 3, Iss 12, p e3938 (2008)
Wilms tumor protein (WT1) is a transcription factor selectively overexpressed in leukemias and cancers; clinical trials are underway that use altered WT1 peptide sequences as vaccines. Here we report a strategy to study peptide-MHC interactions by in
Externí odkaz:
https://doaj.org/article/30d4d05cd0184de5a54cb2a7878f3a05
Publikováno v:
Chemical Communications. 53:5838-5841
A convergent synthesis of the complex, doubly-branched pentasaccharide domain of the natural-product immunoadjuvant jujuboside A is described. The key step is a sterically-hindered glycosylation reaction between a branched trisaccharide trichloroacet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::78e40ca744331adec51dce128dadb860
https://doi.org/10.1039/c7cc01783a
https://doi.org/10.1039/c7cc01783a
Publikováno v:
Accounts of Chemical Research
Conspectus Vaccines based on molecular subunit antigens are increasingly being investigated due to their improved safety and more precise targeting compared to classical whole-pathogen vaccines. However, subunit vaccines are inherently less immunogen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf6c8a0dd2c513b6e91c6d29c17ec7fb
https://doi.org/10.1021/acs.accounts.6b00242
https://doi.org/10.1021/acs.accounts.6b00242
Publikováno v:
Tetrahedron. 74(26)
The jujubosides are saponin natural products reported to have immunoadjuvant, anticancer, antibacterial, antifungal, and antisweet activities. The triterpene component, jujubogenin contains a unique tricyclic ketal motif comprising the DEF ring syste
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::356b56852be2b84f19f7caaa380a01fc
https://pubmed.ncbi.nlm.nih.gov/30467444
https://pubmed.ncbi.nlm.nih.gov/30467444
Autor:
Boris Macek, Virginia A. Pedicord, William E. Walkowicz, Boumediene Soufi, David Y. Gin, Konstantinos J. Mavrakis, Martin L. Miller, Nicholas P. Gauthier, Chris Sander
Publikováno v:
Nature methods
To address limitations of current high-throughput methods for studying cell-cell communication and determining the cell-of-origin of proteins in multicellular environments, we have developed a technique that selectively and continuously labels the pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90071b02c909eafc7afa67a4a2c0d2bd
Publikováno v:
Chemical Communications. 51:13949-13952
We describe a new, versatile synthetic approach to Quillaja saponin variants based on the natural product immunoadjuvant QS-21. This modular, divergent strategy provides efficient access to linear oligosaccharide domain variants with modified sugars
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb780cc7be2ac4dc1c7d8f6fc906d22f
https://doi.org/10.1039/c5cc05244k
https://doi.org/10.1039/c5cc05244k
Publikováno v:
Chemical communications (Cambridge, England). 53(43)
A convergent synthesis of the complex, doubly-branched pentasaccharide domain of the natural-product immunoadjuvant jujuboside A is described. The key step is a sterically-hindered glycosylation reaction between a branched trisaccharide trichloroacet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b24756a3a2a3fa65c3587e581e39c32d
https://pubmed.ncbi.nlm.nih.gov/28498382
https://pubmed.ncbi.nlm.nih.gov/28498382
Autor:
Hakim Djaballah, Yue-Ming Li, David Shum, Deming Chau, Bhavneet Bhinder, Constantin Radu, David Y. Gin, M. Lane Gilchrist
Publikováno v:
Combinatorial Chemistry & High Throughput Screening. 16:415-424
The Notch pathway plays a crucial role in cell fate decisions through controlling various cellular processes. Overactive Notch signal contributes to cancer development from leukemias to solid tumors. γ-Secretase is an intramembrane protease responsi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c95ba4f78b4bb326f9e41c47e075ed57
https://doi.org/10.2174/1386207311316060001
https://doi.org/10.2174/1386207311316060001
Publikováno v:
Methods in Molecular Biology ISBN: 9781493964437
Saponins are triterpene glycoside natural products that exhibit many different biological properties, including activation and modulation of the immune system, and have therefore attracted significant interest as immunological adjuvants for use in va
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44ca2aabe92afd2f2f637381d1208042
https://pubmed.ncbi.nlm.nih.gov/27718185
https://pubmed.ncbi.nlm.nih.gov/27718185
Autor:
Jesús Jiménez-Barbero, Derek S. Tan, David Y. Gin, Francisco Corzana, William E. Walkowicz, Constantine George, Govind Ragupathi, Alberto Fernández-Tejada
Publikováno v:
RIUR: Repositorio Institucional de la Universidad de La Rioja
Universidad de La Rioja (UR)
RIUR. Repositorio Institucional de la Universidad de La Rioja
instname
Universidad de La Rioja (UR)
RIUR. Repositorio Institucional de la Universidad de La Rioja
instname
Immunological adjuvants such as the saponin natural product QS-21 help stimulate the immune response to co-administered antigens and have become increasingly important in the development of prophylactic and therapeutic vaccines. However, clinical use
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::507db1744303ff2a9192de4840c10cab
https://investigacion.unirioja.es/documentos/5bbc685cb750603269e80772
https://investigacion.unirioja.es/documentos/5bbc685cb750603269e80772