Zobrazeno 1 - 10
of 20
pro vyhledávání: '"David Y. Bouffard"'
Publikováno v:
Clinical Trials of Genetic Therapy with Antisense DNA and DNA Vectors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::854c4dcec7a8740970bbd5f4284ce769
https://doi.org/10.1201/9781003064657-15
https://doi.org/10.1201/9781003064657-15
Autor:
J. Ayoub, David Y. Bouffard, Louise F. Momparler, Jeanne Dionne, Richard L. Momparler, Karl Belanger
Publikováno v:
Anti-Cancer Drugs. 8:358-368
5-Aza-2'-deoxycytidine (5-AZA-CdR, Decitabine) is a nucleoside analog and an active drug for the therapy of acute leukemia. The incorporation of 5-AZA-CdR into DNA blocks DNA methylation and can result in the activation of specific genes, such as tum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2383452bc87b7610c4d7429900bd3146
https://doi.org/10.1097/00001813-199704000-00008
https://doi.org/10.1097/00001813-199704000-00008
Publikováno v:
Leukemia Research. 19:849-856
The induction of DNA fragmentation by cytosine arabinoside (araC) and 2',2'-difluorodeoxycytidine (dFdC, gemcitabine) was compared in human leukemic cell lines. For both araC and dFdC this process was time- and concentration-dependent and resulted in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a2f46bee7989e59d79091e3ba0d5f5b
https://doi.org/10.1016/0145-2126(95)00067-4
https://doi.org/10.1016/0145-2126(95)00067-4
Publikováno v:
Anti-Cancer Drugs. 5:223-228
We have investigated the capacity of cyclopentenyl cytosine (CPE-C), a potent inhibitor of CTP synthetase, to modulate the antineoplastic activity of 5-aza-2'-deoxycytidine (DAC) on HL-60 myeloid leukemic cells. The combination of CPE-C and DAC produ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67b42271a4c95e9b4b4049e939021835
https://doi.org/10.1097/00001813-199404000-00014
https://doi.org/10.1097/00001813-199404000-00014
Autor:
Jean-Pierre Marie, Robert Zittoun, David Y. Bouffard, Richard L. Momparler, Jeanine Marquet, Jacqueline Zittoun, Louise F. Momparler
Publikováno v:
International Journal of Cancer. 49:573-576
Drug resistance is one of the major reasons for failure of chemotherapy of acute leukemia with cytosine arabinoside (ARA-C). In order to overcome this problem we have investigated the interaction of ARA-C with 3-deazauridine (3-DU) against HL-60 myel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5b32ac2d986aaad8f22a8b43a9d3cb9
https://doi.org/10.1002/ijc.2910490417
https://doi.org/10.1002/ijc.2910490417
Publikováno v:
Anti-Cancer Drugs. 2:49-56
2',2'-difluorodeoxycytidine (known as dFdC, Gemcitabine and LY188011) is a new analog of deoxycytidine which has demonstrated excellent antineoplastic activity against many kinds of solid tumors and leukemic cell lines. We were interested in the comp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24c409c6db7657adb811e649a9dc06c9
https://doi.org/10.1097/00001813-199102000-00007
https://doi.org/10.1097/00001813-199102000-00007
Autor:
John R. Mackey, Vijaya L. Damaraju, Carol E. Cass, Clarence K W Wong, Lorraine Leblond, David Y. Bouffard, Mike Grey, Marilyn L Clarke, Henriette Gourdeau
Publikováno v:
BMC Cancer, Vol 7, Iss 1, p 121 (2007)
BMC Cancer
BMC Cancer
Background Gemcitabine, a deoxycytidine nucleoside analog, is the current standard chemotherapy used as first-line treatment for patients with locally advanced or metastatic cancer of the pancreas, and extends life survival by 5.7 months. Advanced pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a29ac1c64c98a422d15217124caacad0
https://doi.org/10.1186/1471-2407-7-121
https://doi.org/10.1186/1471-2407-7-121
Autor:
Richard Storer, Ben Tseng, Denis Labreque, John Drewe, Giorgio Attardo, Shailaja Kasibhatla, Jianghong Zhao, Henriette Gourdeau, Yan Wang, Songchun Jiang, David Y. Bouffard, Rabindra Rej, Real Denis, Hong Zhang, William Kemnitzer, Serge Lamothe, Sui Xiong Cai, Karen Meerovitch, John Herich, Charles Blais, Shaojuan Jia
Publikováno v:
Journal of medicinal chemistry. 47(25)
By applying a novel cell- and caspase-based HTS assay, 2-amino-3-cyano-7-(dimethylamino)-4-(3-methoxy-4,5-methylenedioxyphenyl)-4H-chromene (1a) has been identified as a potent apoptosis inducer. Compound 1a was found to induce nuclear fragmentation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28b55f712fbfe080e63799b21a712bb8
https://pubmed.ncbi.nlm.nih.gov/15566300
https://pubmed.ncbi.nlm.nih.gov/15566300