Zobrazeno 1 - 10
of 65
pro vyhledávání: '"David Y, Chen"'
Autor:
Tiago H. Zaninelli, Telma Saraiva-Santos, Brielle H. Patlin, Michael Slade Stratton, David Y. Chen, Felipe A. Pinho-Ribeiro
Publikováno v:
STAR Protocols, Vol 5, Iss 4, Pp 103345- (2024)
Summary: Perineural invasion (PNI) is a significant risk factor for cancer recurrence and metastasis; however, its mechanisms relating to cancer aggressiveness remain poorly understood. Here, we present a protocol for a non-surgical model of PNI in m
Externí odkaz:
https://doaj.org/article/17ba86cde3bd4c5385811877d7937da8
Autor:
Leonid Shmuylovich, MD, PhD, Aubriana M. McEvoy, MD, MS, Ryan C. Fields, MD, Leonel Hernandez-Aya, MD, George Ansstas, MD, David Y. Chen, MD, PhD
Publikováno v:
JAAD Case Reports, Vol 29, Iss , Pp 131-133 (2022)
Externí odkaz:
https://doaj.org/article/d8801dba21884d899ff85dcdd8d0b159
Autor:
Zachary J. Jaeger, Neel S. Raval, Natalia K. A. Maverakis, David Y. Chen, George Ansstas, Angela Hardi, Lynn A. Cornelius
Publikováno v:
Frontiers in Medicine, Vol 10 (2023)
IntroductionNRAS mutations are common in melanoma and confer a worse prognosis. Although most patients with metastatic melanoma receive immune checkpoint inhibitors (ICIs), the impact of NRAS mutational status on their efficacy remains under debate.M
Externí odkaz:
https://doaj.org/article/0958feb70c044ae3aadb4356d112f088
Autor:
Amanda M. Smith, Taylor A. LaValle, Marwan Shinawi, Sai M. Ramakrishnan, Haley J. Abel, Cheryl A. Hill, Nicole M. Kirkland, Michael P. Rettig, Nichole M. Helton, Sharon E. Heath, Francesca Ferraro, David Y. Chen, Sangeeta Adak, Clay F. Semenkovich, Diana L. Christian, Jenna R. Martin, Harrison W. Gabel, Christopher A. Miller, Timothy J. Ley
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Germline mutations in the DNMT3A gene can cause an overgrowth syndrome associated with behavioural and hematopoietic phenotypes. Here the authors describe a mouse model of this syndrome that recapitulates many of these features, including conserved a
Externí odkaz:
https://doaj.org/article/5e0d8e3763324ed0920eb1d6b6fbeadf
Autor:
Amanda M. Smith, Angela M. Verdoni, Haley J. Abel, David Y. Chen, Shamika Ketkar, Elizabeth R. Leight, Christopher A. Miller, Timothy J. Ley
Publikováno v:
iScience, Vol 25, Iss 4, Pp 104004- (2022)
Summary: Mutations in the gene encoding DNA methyltransferase 3A (DNMT3A) are the most common cause of clonal hematopoiesis and are among the most common initiating events of acute myeloid leukemia (AML). Studies in germline and somatic Dnmt3a knocko
Externí odkaz:
https://doaj.org/article/01b3d370f1c6454ba941449503cd5b03
Autor:
Allegra A. Petti, Stephen R. Williams, Christopher A. Miller, Ian T. Fiddes, Sridhar N. Srivatsan, David Y. Chen, Catrina C. Fronick, Robert S. Fulton, Deanna M. Church, Timothy J. Ley
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-2 (2022)
Externí odkaz:
https://doaj.org/article/72f3589db36b4708b693e32dec56bdc8
Autor:
Allegra A. Petti, Stephen R. Williams, Christopher A. Miller, Ian T. Fiddes, Sridhar N. Srivatsan, David Y. Chen, Catrina C. Fronick, Robert S. Fulton, Deanna M. Church, Timothy J. Ley
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
The advent of single-cell RNA sequencing has revealed significant transcriptional heterogeneity in cancer, but its relationship to genomic heterogeneity remains unclear. Focusing on acute myeloid leukemia samples, the authors describe a general appro
Externí odkaz:
https://doaj.org/article/e7387f8418fd4439a8a668e9564cc12b
Autor:
Armin Ghobadi, Jack H. Landmann, Alun Carter, Matthew L. Cooper, Mehmet Emrah Selli, Jufang Chang, Matthew Baker, Christopher A. Miller, Francesca Ferraro, David Y. Chen, Amanda M. Smith, Taylor A. LaValle, Eric J. Duncavage, Justin Chou, Victor Tam, Joseph M. Benoun, Jenny Nater, Nathalie Scholler, Francesca Milletti, Remus Vezan, Adrian Bot, John M. Rossi, Nathan Singh
Publikováno v:
Blood Advances. 6:5634-5640
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7d8f41309b64dd6dcd54863fffe9d9b
https://doi.org/10.1182/bloodadvances.2022007705
https://doi.org/10.1182/bloodadvances.2022007705
Autor:
James J-D. Hsieh, Emily H-Y. Cheng, Dongsi Lu, Brian A. Van Tine, Satoru Sasagawa, Ho-Chou Tu, Shugaku Takeda, Han Liu, David Y. Chen
Taspase1, the mixed lineage leukemia and TFIIAα-β cleaving protease, enables cell proliferation and permits oncogenic initiation. Here, we show its critical role in cancer maintenance and thus offer a new anticancer target. Taspase1 is overexpresse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::811fcf0adc78329665f1239670f1898f
https://doi.org/10.1158/0008-5472.c.6500150.v1
https://doi.org/10.1158/0008-5472.c.6500150.v1
Autor:
James J-D. Hsieh, Emily H-Y. Cheng, Dongsi Lu, Brian A. Van Tine, Satoru Sasagawa, Ho-Chou Tu, Shugaku Takeda, Han Liu, David Y. Chen
Supplementary Methods, Figures 1-11, Table 1 from Taspase1 Functions as a Non-Oncogene Addiction Protease that Coordinates Cancer Cell Proliferation and Apoptosis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5522b38fb2f90e0fc0fc407bf08502e7
https://doi.org/10.1158/0008-5472.22382282.v1
https://doi.org/10.1158/0008-5472.22382282.v1