Zobrazeno 1 - 10
of 95
pro vyhledávání: '"David Wotton"'
Autor:
Chun-Song Yang, Kasey Jividen, Teddy Kamata, Natalia Dworak, Luke Oostdyk, Bartlomiej Remlein, Yasin Pourfarjam, In-Kwon Kim, Kang-Ping Du, Tarek Abbas, Nicholas E. Sherman, David Wotton, Bryce M. Paschal
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Androgen receptor (AR) signaling is regulated by multiple post-translational modifications. Here, the authors identify the writer and reader enzymes for AR ADP-ribosylation and show how they modulate AR signaling output in prostate cancer cells.
Externí odkaz:
https://doaj.org/article/4e3161d87a9e495bb19ec9d697ca2a8c
Autor:
Teddy Kamata, Chun-Song Yang, Tiffany A. Melhuish, Henry F. Frierson Jr., David Wotton, Bryce M. Paschal
Publikováno v:
Cells, Vol 10, Iss 2, p 363 (2021)
Poly-ADP-ribose polymerases (PARPs) are enzymes that catalyze ADP-ribosylation and play critical roles in normal and disease settings. The PARP family member, PARP7, is a mono-ADP-ribosyltransferase that has been suggested to play a tumor suppressive
Externí odkaz:
https://doaj.org/article/5fa5169fed0144948df558ff176a6223
Autor:
Yi Hao, Glen A Bjerke, Karolina Pietrzak, Tiffany A Melhuish, Yu Han, Stephen D Turner, Henry F Frierson, David Wotton
Publikováno v:
PLoS Genetics, Vol 14, Iss 5, p e1007409 (2018)
Although treatment options for localized prostate cancer (CaP) are initially effective, the five-year survival for metastatic CaP is below 30%. Mutation or deletion of the PTEN tumor suppressor is a frequent event in metastatic CaP, and inactivation
Externí odkaz:
https://doaj.org/article/7418ca9778e14a7289fef43b2453f15a
Autor:
Camilla Pramfalk, Tiffany A. Melhuish, David Wotton, Zhao-Yan Jiang, Mats Eriksson, Paolo Parini
Publikováno v:
Journal of Lipid Research, Vol 55, Iss 4, Pp 709-717 (2014)
Acat2 [gene name: sterol O-acyltransferase 2 (SOAT2)] esterifies cholesterol in enterocytes and hepatocytes. This study aims to identify repressor elements in the human SOAT2 promoter and evaluate their in vivo relevance. We identified TG-interacting
Externí odkaz:
https://doaj.org/article/3c5d58da3a6842ff840aba6230e5c72d
Publikováno v:
PLoS ONE, Vol 11, Iss 5, p e0155837 (2016)
Tgif1 and Tgif2 are transcriptional repressors that inhibit the transcriptional response to transforming growth factor β signaling, and can repress gene expression by direct binding to DNA. Loss of function mutations in TGIF1 are associated with hol
Externí odkaz:
https://doaj.org/article/8d7338ab36cb48ce9da6aee61ca47cb1
Autor:
Glen A Bjerke, Karolina Pietrzak, Tiffany A Melhuish, Henry F Frierson, Bryce M Paschal, David Wotton
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e92800 (2014)
Recent work with mouse models of prostate cancer (CaP) has shown that inactivation of TGFβ signaling in prostate epithelium can cooperate with deletion of the Pten tumor suppressor to drive locally aggressive cancer and metastatic disease. Here, we
Externí odkaz:
https://doaj.org/article/3f8f45fe4bb14b60932ec0d8371e2bd9
Publikováno v:
PLoS Genetics, Vol 8, Iss 2, p e1002524 (2012)
Holoprosencephaly (HPE) is a severe human genetic disease affecting craniofacial development, with an incidence of up to 1/250 human conceptions and 1.3 per 10,000 live births. Mutations in the Sonic Hedgehog (SHH) gene result in HPE in humans and mi
Externí odkaz:
https://doaj.org/article/53e6101c77a64f39bf792acc949d27b5
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e35460 (2012)
Transforming growth factor β (TGFβ) signaling regulates cell cycle progression in several cell types, primarily by inducing a G1 cell cycle arrest. Tgif1 is a transcriptional corepressor that limits TGFβ responsive gene expression. Here we demonst
Externí odkaz:
https://doaj.org/article/847e1aa759ac47f39e947fdd1c4c2a7a
Autor:
Janine C Quijano, Michael J Stinchfield, Brad Zerlanko, Ying Y Gibbens, Norma T Takaesu, Cathy Hyman-Walsh, David Wotton, Stuart J Newfeld
Publikováno v:
PLoS ONE, Vol 5, Iss 7, p e11619 (2010)
The Sno oncogene (Snoo or dSno in Drosophila) is a highly conserved protein and a well-established antagonist of Transforming Growth Factor-beta signaling in overexpression assays. However, analyses of Sno mutants in flies and mice have proven enigma
Externí odkaz:
https://doaj.org/article/eb64cfa888bf476fab06916cc78cdb94
Autor:
Jacqueline C Merrill, Tiffany A Melhuish, Michael H Kagey, Shen-Hsi Yang, Andrew D Sharrocks, David Wotton
Publikováno v:
PLoS ONE, Vol 5, Iss 1, p e8794 (2010)
Modification of proteins by the small ubiquitin like modifier (SUMO) is an essential process in mammalian cells. SUMO is covalently attached to lysines in target proteins via an enzymatic cascade which consists of E1 and E2, SUMO activating and conju
Externí odkaz:
https://doaj.org/article/3d760fa53bf649029a47b25738bbee37