Robo signalling controls pancreatic progenitor identity by regulating Tead transcription factors

Autor: Sophie Escot, David Willnow, Heike Naumann, Silvia Di Francescantonio, Francesca M. Spagnoli

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)

A role for Slit/Robo signalling in pancreas development has not been defined. Here, the authors generate Robo1/Robo2 knockout mice to identify both as needed for establishing initial pancreatic cell identity as well as for proliferation and survival

Externí odkaz: https://doaj.org/article/3333c45137184a129f28864d1c262e72

Development of a 3D atlas of the embryonic pancreas for topological and quantitative analysis of heterologous cell interactions

Autor: Laura Glorieux, Aleksandra Sapala, David Willnow, Manon Moulis, Anna Salowka, Jean-Francois Darrigrand, Shlomit Edri, Anat Schonblum, Lina Sakhneny, Laura Schaumann, Harold F. Gómez, Christine Lang, Lisa Conrad, Fabien Guillemot, Shulamit Levenberg, Limor Landsman, Dagmar Iber, Christophe E. Pierreux, Francesca M. Spagnoli

Publikováno v: Development, 149 (3)
Development (Cambridge, England), Vol. 149, no.3, p. dev199655 [1-14] (2022)

Generating comprehensive image maps, while preserving spatial three-dimensional (3D) context, is essential in order to locate and assess quantitatively specific cellular features and cell-cell interactions during organ development. Despite recent adv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::549a2a83bba3bec8803fc07efef75b20
https://hdl.handle.net/20.500.11850/530558

Quantitative lineage analysis identifies a hepato-pancreato-biliary progenitor niche

Autor: David, Willnow, Uwe, Benary, Anca, Margineanu, Maria Lillina, Vignola, Fabian, Konrath, Igor M, Pongrac, Zahra, Karimaddini, Alessandra, Vigilante, Jana, Wolf, Francesca M, Spagnoli

Publikováno v: Nature. 597(7874)

Studies based on single cells have revealed vast cellular heterogeneity in stem cell and progenitor compartments, suggesting continuous differentiation trajectories with intermixing of cells at various states of lineage commitment and notable degrees

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d7d92890cbd3413fbf1eb027a5abff8a
https://pubmed.ncbi.nlm.nih.gov/34433966

A Specialized Niche in the Pancreatic Microenvironment Promotes Endocrine Differentiation

Autor: Licia Selleri, Francesca M. Spagnoli, Jean Francois Darrigrand, David Willnow, Heather Wilson, Nancy Mah, Silvia Ruzittu, Laura Mueller, Corinna Cozzitorto, Amir Ala Mahmoud, Daniel Khosravinia, Maurizio Risolino

Publikováno v: Cozzitorto, C, Mueller, L, Ruzittu, S, Mah, N, Willnow, D, Darrigrand, J F, Wilson, H, Khosravinia, D, Mahmoud, A A, Risolino, M, Selleri, L & Spagnoli, F M 2020, ' A Specialized Niche in the Pancreatic Microenvironment Promotes Endocrine Differentiation ', Developmental Cell, vol. 55, no. 2, pp. 150-162.e6 . https://doi.org/10.1016/j.devcel.2020.08.003
Developmental Cell
Dev Cell

The interplay between pancreatic epithelium and the surrounding microenvironment is pivotal for pancreas formation and differentiation as well as adult organ homeostasis. The mesenchyme is the main component of the embryonic pancreatic microenvironme

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00225b03405ce43e245f4650fade55ea
https://doi.org/10.1016/j.devcel.2020.08.003

Elucidating hepatic and pancreatic fate acquisition in the early mouse embryo

Autor: David Willnow, Igor M. Pongrac, Francesca M. Spagnoli

Publikováno v: Mechanisms of Development. 145:S154

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c86d95f19c9202992c319c46f81d71b8
https://doi.org/10.1016/j.mod.2017.04.437