Zobrazeno 1 - 10
of 674
pro vyhledávání: '"David Wan"'
Autor:
Xingfei Zhu, Wei Liu, Xiangcheng Tang, Yulin Chen, Xiangyu Ge, Qin Ke, Xingmiao Liang, Yuwen Gan, Yingfeng Zheng, Ming Zou, Mi Deng, Yizhi Liu, David Wan-Cheng Li, Lili Gong
Publikováno v:
Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-19 (2023)
Abstract Background Chronic inflammation significantly contributes to photoreceptor death in blinding retinal diseases such as age-related macular degeneration (AMD) and retinitis pigmentosa (RP). Bromodomain and extraterminal domain (BET) proteins a
Externí odkaz:
https://doaj.org/article/07da5be290f84d76b80e6df63a3d9aea
Autor:
Jiawen Xiang, Anthony J. Pompetti, Adam P. Faranda, Yan Wang, Samuel G. Novo, David Wan-Cheng Li, Melinda K. Duncan
Publikováno v:
Cells, Vol 12, Iss 22, p 2636 (2023)
The late embryonic mouse lens requires the transcription factor ATF4 for its survival although the underlying mechanisms were unknown. Here, RNAseq analysis revealed that E16.5 Atf4 null mouse lenses downregulate the mRNA levels of lens epithelial ma
Externí odkaz:
https://doaj.org/article/e82b2b3d7e8846e5a2fb05408ab2da61
Autor:
Lan Zhang, Ling Wang, Xue‐Bin Hu, Min Hou, Yuan Xiao, Jia‐Wen Xiang, Jie Xie, Zhi‐Gang Chen, Tian‐Heng Yang, Qian Nie, Jia‐Ling Fu, Yan Wang, Shu‐Yu Zheng, Yun‐Fei Liu, Yu‐Wen Gan, Qian Gao, Yue‐Yue Bai, Jing‐Miao Wang, Rui‐Li Qi, Ming Zou, Qin Ke, Xing‐Fei Zhu, Lili Gong, Yizhi Liu, David Wan‐Cheng Li
Publikováno v:
Advanced Science, Vol 9, Iss 14, Pp n/a-n/a (2022)
Abstract The methyltransferase EZH2 plays an important role in regulating chromatin conformation and gene transcription. Phosphorylation of EZH2 at S21 by AKT kinase suppresses its function. However, protein phosphatases responsible for the dephospho
Externí odkaz:
https://doaj.org/article/8579a5bb1725406199cc47ccb8740c05
Autor:
Emmanuel Attah, Tracey A. Martin, Emily S. Smith, Sunena Tewani, Kaveh Hajifathalian, Reem Z. Sharaiha, Carl V. Crawford, David Wan
Publikováno v:
Endoscopy International Open, Vol 09, Iss 09, Pp E1435-E1444 (2021)
Background and study aim COVID-19 patients are at increased risk for venous thromboembolism (VTE) requiring the use of anticoagulation. Gastrointestinal bleeding (GIB) is increasingly being reported, complicating the decision to initiate or resume an
Externí odkaz:
https://doaj.org/article/ba064421f3fa476fb744fabb7e75e6c3
Autor:
Qian Nie, Huimin Chen, Ming Zou, Ling Wang, Min Hou, Jia-Wen Xiang, Zhongwen Luo, Xiao-Dong Gong, Jia-Ling Fu, Yan Wang, Shu-Yu Zheng, Yuan Xiao, Yu-Wen Gan, Qian Gao, Yue-Yue Bai, Jing-Miao Wang, Lan Zhang, Xiang-Cheng Tang, Xuebin Hu, Lili Gong, Yizhi Liu, David Wan-Cheng Li
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Protein sumoylation is one of the most important post-translational modifications regulating many biological processes (Flotho A & Melchior F. 2013. Ann Rev. Biochem. 82:357–85). Our previous studies have shown that sumoylation plays a fundamental
Externí odkaz:
https://doaj.org/article/cc54ff617256456fb037d204f1f33b7b
Publikováno v:
Stem Cell Research, Vol 53, Iss , Pp 102310- (2021)
MERTK mutations are associate with rod-cone dystrophies. To enable investigations into the mechanism of this disease, we generated a cell line resource of H9 human embryonic stem cells harboring large fragment deletion mutation in a homozygous state
Externí odkaz:
https://doaj.org/article/42674e223d904a38ac50364193d8c0e8
Autor:
Qin Ke, Lili Gong, Xingfei Zhu, Ruili Qi, Ming Zou, Baoxin Chen, Wei Liu, Shan Huang, Yizhi Liu, David Wan-Cheng Li
Publikováno v:
Cells, Vol 11, Iss 9, p 1552 (2022)
Multinucleated retinal pigment epithelium (RPE) cells have been reported in humans and other mammals. Rodents have an extremely high percentage of multinucleated cells (more than 80%). Both mouse and human multinucleated RPE cells exhibit specific re
Externí odkaz:
https://doaj.org/article/b9aafb32e3ce4f4aae2e1227884e6750
Autor:
Xiangcheng Tang, Zhigang Chen, Xuhua Tan, Lixia Luo, Xialin Liu, Lili Gong, David Wan-Cheng Li, Yizhi Liu
Publikováno v:
Stem Cell Research, Vol 49, Iss , Pp 102057- (2020)
Mutations in the CRB1 gene reportedly cause early-onset autosomal recessive retinitis pigmentosa (RP), which can result in severe loss of vision at an early age. To investigate the mechanism of CRB1-knockout (CRB1-/-) induced RP, we generated a subli
Externí odkaz:
https://doaj.org/article/df3cb95cd9e14b5b92ac566c776cf32a
Autor:
Xiangcheng Tang, Xinyu Liu, Zhigang Chen, Lixia Luo, Xialin Liu, Juan Deng, David Wan-Cheng Li, Yizhi Liu
Publikováno v:
Stem Cell Research, Vol 45, Iss , Pp - (2020)
We isolated peripheral blood mononuclear cells from a patient diagnosed with early-onset non-syndromic retinitis pigmentosa caused by compound heterozygous mutations in CRB1 (NM_001257965): c.1369C>T (p.R457X) and c.2027C>T (p.T676M). These cells wer
Externí odkaz:
https://doaj.org/article/bd39e9950e5f49eb8a6ab28caea094fe
Autor:
He-Ge Chen, Wen-Jun Han, Mi Deng, Jichao Qin, Dan Yuan, Jin-Ping Liu, Ling Xiao, Lili Gong, Songping Liang, Jian Zhang, Yun Liu, David Wan-Cheng Li
Publikováno v:
PLoS ONE, Vol 4, Iss 9, p e7019 (2009)
Protein phosphatases-2A (PP-2A) is a major serine/threonine phosphatase and accounts for more than 50% serine/threonine phosphatase activity in eukaryotes. The holoenzyme of PP-2A consists of the scaffold A subunit, the catalytic C subunit and the re
Externí odkaz:
https://doaj.org/article/c32429e7e4a24cf28c23fa725b9d13e1