Zobrazeno 1 - 10
of 24
pro vyhledávání: '"David W. Will"'
Autor:
Nikolaos Karantzelis, Michalis Petropoulos, Valeria De Marco, David A. Egan, Alexander Fish, Evangelos Christodoulou, David W. Will, Joe D. Lewis, Anastassis Perrakis, Zoi Lygerou, Stavros Taraviras
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
DNA replication initiation requires the loading of MCM2-7 complexes at the origins of replication during G1. Replication licensing renders chromatin competent for DNA replication and its tight regulation is essential to prevent aberrant DNA replicati
Externí odkaz:
https://doaj.org/article/a12e5a12cb4d47728c4807ff7f7cae4b
Autor:
María Isabel Fernández-Bachiller, Songhwan Hwang, María Elena Schembri, Peter Lindemann, Mónica Guberman, Svenja Herziger, Edgar Specker, Hans Matter, David W. Will, Jörg Czech, Michael Wagner, Armin Bauer, Herman Schreuder, Kurt Ritter, Matthias Urmann, Volkmar Wehner, Han Sun, Marc Nazaré
Publikováno v:
Journal of Medicinal Chemistry. 65:13013-13028
The accurate prediction of protein-ligand binding affinity belongs to one of the central goals in computer-based drug design. Molecular dynamics (MD)-based free energy calculations have become increasingly popular in this respect due to their accurac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b8a1e421784852173ad676bcf5b0524
https://doi.org/10.1021/acs.jmedchem.2c00865
https://doi.org/10.1021/acs.jmedchem.2c00865
Autor:
David W. Will, Walter Nickel, Carlo A. Beretta, Mennatallah Ahmed, Cyril Legrand, Joe Lewis, Peter Sehr, Hans-Michael Müller, Sabine Wegehingel, Ana Yagüe Relimpio, Alina Muschko
Publikováno v:
FEBS Letters. 593:2162-2176
Fibroblast growth factor 2 (FGF2) is a cell survival factor with crucial functions in tumor-induced angiogenesis. Here, we describe a novel time-resolved FGF2 signaling assay based upon live cell imaging of neuroblastoma cells. To validate this syste
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b56293268b4f34c8b8192f5825ca86f3
https://doi.org/10.1002/1873-3468.13462
https://doi.org/10.1002/1873-3468.13462
Autor:
David W. Will, Nataliia V. Shymanska, Cécile Echalier, Christine Koehler, Christopher D. Reinkemeier, Paul F. Sauter, Edward A. Lemke, Carsten Schultz, Anna Rutkowska
Publikováno v:
Chemistry – A European Journal
Chemistry (Weinheim an Der Bergstrasse, Germany)
Chemistry (Weinheim an Der Bergstrasse, Germany)
Bioorthogonal reactions are ideally suited to selectively modify proteins in complex environments, even in vivo. Kinetics and product stability of these reactions are crucial parameters to evaluate their usefulness for specific applications. Strain p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d54b3cc6465af83c644b8926d335c35
Autor:
Mareike Grotwinkel, Nikolai Hentze, Sabine Wegehingel, Ulrike Uhrig, Eleni Dimou, David W. Will, Walter Nickel, Matthias P. Mayer, Hans-Michael Müller, Peter Sehr, Julia P. Steringer, Giuseppe La Venuta, Joe Lewis
Publikováno v:
Journal of Biological Chemistry. 291:17787-17803
Fibroblast growth factor 2 (FGF2) is a potent mitogen promoting both tumor cell survival and tumor-induced angiogenesis. It is secreted by an unconventional secretory mechanism that is based upon direct translocation across the plasma membrane. Key s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9090e59030196207961d1718e02770d
https://doi.org/10.1074/jbc.m116.729384
https://doi.org/10.1074/jbc.m116.729384
Autor:
Dani Dumitriu, Andréane Lavallée, Jessica L. Riggs, Cynthia A. Frosch, Tyson V. Barker, Debra L. Best, Brenda Blasingame, Jessica Bushar, Dominique Charlot-Swilley, Elizabeth Erickson, Morgan A. Finkel, Bryn Fortune, Leah Gillen, Marty Martinez, Usha Ramachandran, Lee M. Sanders, David W. Willis, Nikki Shearman
Publikováno v:
Frontiers in Pediatrics, Vol 11 (2023)
Here, we introduce the Early Relational Health (ERH) Learning Community's bold, large-scale, collaborative, data-driven and practice-informed research agenda focused on furthering our mechanistic understanding of ERH and identifying feasible and effe
Externí odkaz:
https://doaj.org/article/3fd62bed61744b56b45d374077fde46c
Autor:
Tom Brown, David W. Will
Publikováno v:
Tetrahedron Letters. 33:2729-2732
Compounds have been synthesized which allow the attachment of Vitamin E to the 5′-, and 3′-ends of oligonucleotides, and the attachment of a Vitamin E moiety on an octamethylene spacer to the 5′-end, all during solid-phase synthesis. The effect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f38f3777127a0a3de57710f318dbd99a
https://doi.org/10.1016/s0040-4039(00)79068-x
https://doi.org/10.1016/s0040-4039(00)79068-x
Publikováno v:
Nucleic Acids Research. 20:3411-3417
A number of phosphoramidite monomers have been prepared and used in the synthesis of antisense phosphorothioate oligonucleotides bearing 5'-polyalkyl and cholesterol moieties. Similar groups have also been attached to the 3'-end of oligonucleotides b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::613baac2a945674a1a4544fa694fe8b9
https://doi.org/10.1093/nar/20.13.3411
https://doi.org/10.1093/nar/20.13.3411
Autor:
David W. Will, et al. et al.
Publikováno v:
ChemInform. 35
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7be5bfc7b7ea94eb42a8338d08e71115
https://doi.org/10.1002/chin.200439217
https://doi.org/10.1002/chin.200439217
Publikováno v:
Nucleic acids research. 21(19)
Poly-labelled oligonucleotides can be synthesised using a modified nucleoside phosphoramidite approach (1, 2). However, the use of this approach for the integration of multiple labels into DNA and RNA is expensive and labour intensive because of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87f2d972d7e2c56735757a06ecb81fcf
https://pubmed.ncbi.nlm.nih.gov/8233810
https://pubmed.ncbi.nlm.nih.gov/8233810