Zobrazeno 1 - 10
of 12
pro vyhledávání: '"David W. Souza"'
Autor:
David W. Souza, Donna Armentano
Publikováno v:
BioTechniques, Vol 26, Iss 3, Pp 502-508 (1999)
pAdvantage is a rapid cloning system for generating recombinant adenoviruses. The system is based on manipulating the fulllength adenovirus genome as a stable plasmid in E. coli using intron-encoded endonucleases. These intron-encoded endonucleases c
Externí odkaz:
https://doaj.org/article/dd8bc3ee810645fd8e27bb438981fd35
Autor:
Patricia Berthelette, Bindu Nambiar, Donna Armentano, Cathleen Sookdeo, Brenda Burnham, Susan Piraino, Sirkka Kyostio-Moore, Shelley Nass, Karen A. Vincent, Seng H. Cheng, Catherine R. O'Riordan, David W. Souza, Robert B. Jackson
Publikováno v:
Human gene therapy methods. 28(1)
Several ongoing clinical studies are evaluating recombinant adeno-associated virus (rAAV) vectors as gene delivery vehicles for a variety of diseases. However, the production of vectors with genomes >4.7 kb is challenging, with vector preparations fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f1e64b78540f6afd300d3eb7e89bf64
https://pubmed.ncbi.nlm.nih.gov/28166648
https://pubmed.ncbi.nlm.nih.gov/28166648
Autor:
Scott D. Bercury, John Marshall, Nilesh Pande, Lisa Woodworth, Seng H. Cheng, Ronald K. Scheule, Jennifer B. Nietupski, Mark Bree, David W. Souza, Robin J. Ziegler, Michael Lukason, Elizabeth Meyers, Joseph W. Foley, Gregory D Hurlbut
Publikováno v:
Molecular Therapy. 18:1983-1994
Liver-directed gene therapy with adeno-associated virus (AAV) vectors effectively treats mouse models of lysosomal storage diseases (LSDs). We asked whether these results were likely to translate to patients. To understand to what extent preexisting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4233401d6c87256f502e812872df1557
https://doi.org/10.1038/mt.2010.175
https://doi.org/10.1038/mt.2010.175
Autor:
Donna Armentano, Sirkka Kyostio-Moore, Catherine R. O'Riordan, Robert B. Jackson, Cathleen Sookdeo, Seng H. Cheng, David W. Souza, Shelley Nass, Karen A. Vincent, Brenda Burnham, Patricia Berthelette, Bindu Nambiar
Publikováno v:
Molecular Therapy. 24:S40
Recombinant adeno-associated virus (rAAV) vectors are being evaluated as gene delivery vehicles in several clinical trials. The 4.7 kb wild-type (WT) size genome of AAV presents a challenge for incorporating larger transgenes with incomplete vector g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::012317521e74a92242430f1b0aa1076f
https://doi.org/10.1016/s1525-0016(16)32901-x
https://doi.org/10.1016/s1525-0016(16)32901-x
Autor:
Alan E. Smith, M. J. Welsh, Parthasarathy Manavalan, S H Cheng, Sucharita Paul, D. P. Rich, Matthew P. Anderson, David W. Souza, Richard J. Gregory
Publikováno v:
Molecular and Cellular Biology. 11:3886-3893
One feature of the mutations thus far found to be associated with the disease cystic fibrosis (CF) is that many of them are clustered within the first nucleotide-binding domain (NBD) of the CF transmembrane conductance regulator (CFTR). We sought to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ccb071c669d86c5da624947978225da3
https://doi.org/10.1128/mcb.11.8.3886
https://doi.org/10.1128/mcb.11.8.3886
Autor:
Richard J. Gregory, Catherine R. O'Riordan, Seng H. Cheng, David W. Souza, Sucharita Paul, John Marshall, Gary A. White, Alan E. Smith
Publikováno v:
Cell. 63:827-834
The gene associated with cystic fibrosis (CF) encodes a membrane-associated, N-linked glycoprotein called CFTR. Mutations were introduced into CFTR at residues known to be altered in CF chromosomes and in residues believed to play a role in its funct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b99e5cde8be03decd7ebec852fd828b9
https://doi.org/10.1016/0092-8674(90)90148-8
https://doi.org/10.1016/0092-8674(90)90148-8
Publikováno v:
Gene therapy. 14(1)
Glucagon-like peptide 1 (GLP-1) is a promising candidate for the treatment of type II diabetes. However, the short in vivo half-life of GLP-1 has made peptide-based treatments challenging. Gene therapy aimed at achieving continuous GLP-1 expression p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aeaa2506cb32189af08821a66c859ce7
https://pubmed.ncbi.nlm.nih.gov/16929351
https://pubmed.ncbi.nlm.nih.gov/16929351
Autor:
Maribeth Cherry, Christine M. Barbon, Seng H. Cheng, Christine Ford, Robin J. Ziegler, Guangping Gao, Donna Armentano, David W. Souza, Robert J. Desnick, James M. Wilson, Barrie J. Carter, Chester Li, Scott Lonning, Simon Godwin, Richard J. Gregory, Samuel C. Wadsworth, Richard W. Peluso
Publikováno v:
Molecular therapy : the journal of the American Society of Gene Therapy. 9(2)
The successful application of gene therapy for the treatment of genetic diseases such as Fabry is reliant on the development of vectors that are safe and that facilitate sustained expression of therapeutic levels of the transgene product. Here, we re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bd393094c2f8713852f7267f46108f5
https://pubmed.ncbi.nlm.nih.gov/14759807
https://pubmed.ncbi.nlm.nih.gov/14759807
Autor:
Michiharu Suga, Shaf Keshavjee, David W. Souza, Judith A. St. George, Alexandra A. MacLean, Mingyao Liu
Publikováno v:
American journal of respiratory and critical care medicine. 165(3)
Post-transplant bronchiolitis obliterans (BO) is characterized by fibroproliferation and fibrous obliteration of distal airways in chronically rejected lungs. In this study, using a rat heterotopic allogeneic tracheal transplant model of BO, we evalu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e8438399f3812df3fdf7de870519a0f
https://pubmed.ncbi.nlm.nih.gov/11818331
https://pubmed.ncbi.nlm.nih.gov/11818331
Autor:
Donna Armentano, David W. Souza
Publikováno v:
BioTechniques. 26(3)
pAdvantage is a rapid cloning system for generating recombinant adenoviruses. The system is based on manipulating the fulllength adenovirus genome as a stable plasmid in E. coli using intron-encoded endonucleases. These intron-encoded endonucleases c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95d1c40fe668002c5a547f031c592999
https://pubmed.ncbi.nlm.nih.gov/10090992
https://pubmed.ncbi.nlm.nih.gov/10090992