Zobrazeno 1 - 10
of 30
pro vyhledávání: '"David W. Scheel"'
Autor:
Sara E Vazquez, Elise MN Ferré, David W Scheel, Sara Sunshine, Brenda Miao, Caleigh Mandel-Brehm, Zoe Quandt, Alice Y Chan, Mickie Cheng, Michael German, Michail Lionakis, Joseph L DeRisi, Mark S Anderson
Publikováno v:
eLife, Vol 9 (2020)
The identification of autoantigens remains a critical challenge for understanding and treating autoimmune diseases. Autoimmune polyendocrine syndrome type 1 (APS1), a rare monogenic form of autoimmunity, presents as widespread autoimmunity with T and
Externí odkaz:
https://doaj.org/article/1520599b04384010a0a8ecbeae8656f8
Autor:
Yoshinori Shimajiri, Yasuhiro Kosaka, David W. Scheel, Francis C. Lynn, Nina Kishimoto, Juehu Wang, Shuhong Zhao, Michael S. German
Publikováno v:
Disease Models & Mechanisms, Vol 4, Iss 2, Pp 268-276 (2011)
SUMMARY Transient expression of the transcription factor neurogenin-3 marks progenitor cells in the pancreas as they differentiate into islet cells. We developed a transgenic mouse line in which the surrogate markers secreted alkaline phosphatase (Se
Externí odkaz:
https://doaj.org/article/1f904796f3c549ec97c222899ab17a35
Autor:
David W. Scheel, Sara Sunshine, Michael S. German, Brenda Miao, Michail S. Lionakis, Joseph L. DeRisi, Alice Y. Chan, Elise M. N. Ferré, Sara E. Vazquez, Mickie H. Cheng, Zoe Quandt, Caleigh Mandel-Brehm, Mark S. Anderson
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::71d8b457599e85659e78a4ba9773707a
https://doi.org/10.7554/elife.55053.sa2
https://doi.org/10.7554/elife.55053.sa2
Autor:
Gérard Gradwohl, Jorge Ferrer, Marie Lemper, Christoffer Nord, Paola Bonfanti, Michael S. German, Ruth Shemer, Sofie De Groef, Geert Stangé, Fong Cheng Pan, Harry Heimberg, Luc Bouwens, Luc Baeyens, Ulf Ahlgren, Doris A. Stoffers, Gunter Leuckx, Mark Van de Casteele, Guoqiang Gu, Yuval Dor, David W. Scheel, Christopher V.E. Wright
Publikováno v:
Nature biotechnology, vol 38, iss 3
Reprogramming of pancreatic exocrine cells into cells resembling beta cells may provide a strategy for treating diabetes. Here we show that transient administration of epidermal growth factor and ciliary neurotrophic factor to adult mice with chronic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f215a12379c8050a6180141f908b6c7d
https://pubmed.ncbi.nlm.nih.gov/24240391
https://pubmed.ncbi.nlm.nih.gov/24240391
Autor:
Elise M. N. Ferré, Mickie Cheng, Michail S. Lionakis, Zoe Quandt, Sara Sunshine, Brenda Miao, Michael S. German, Caleigh Mandel-Brehm, Sara E. Vazquez, Alice Y. Chan, Mark S. Anderson, Joseph L. DeRisi, David W. Scheel
The identification of autoantigens remains a critical challenge for understanding and treating autoimmune diseases. Autoimmune polyendocrine syndrome type 1 (APS1), a rare monogenic form of autoimmunity, presents as widespread autoimmunity with T and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05804619cf7beeda76f3c2bc4f2ca4f7
Autor:
Louis Z Sharp, Kosaku Shinoda, Haruya Ohno, David W Scheel, Emi Tomoda, Lauren Ruiz, Houchun Hu, Larry Wang, Zdena Pavlova, Vicente Gilsanz, Shingo Kajimura
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e49452 (2012)
Brown adipose tissue (BAT) dissipates chemical energy and generates heat to protect animals from cold and obesity. Rodents possess two types of UCP-1 positive brown adipocytes arising from distinct developmental lineages: "classical" brown adipocytes
Externí odkaz:
https://doaj.org/article/85bb19d86a734fa4985c9657e0e0deac
Publikováno v:
Diabetes. 68
Geminin (Gmnn) is a coiled-coil nuclear protein originally identified as a DNA replication inhibitor. In addition, nuclear Gmnn regulates gene expression by interacting (through a domain distinct from the Cdt1-interacting domain) with Brg1, the catal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7fdabea6feb25598720b8417e55496d3
https://doi.org/10.2337/db19-106-or
https://doi.org/10.2337/db19-106-or
Autor:
Phuong Hoang, David W. Scheel, Gerard Honig, Hector Macias, Panid Sharifnia, Lisa Yu, Greg M. Ku, Jean B. Regard, Takeshi Miyatsuka, Miles Berger, Angela Liou, Bruce R. Conklin, Juehu Wang, Laurence H. Tecott, Shaun R. Coughlin, Yunshuo Tang, Michael S. German, Evan S. Deneris, Hail Kim
Gi-GPCRs, G protein-coupled receptors that signal via Gα proteins of the i/o class (Gαi/o), acutely regulate cellular behaviors widely in mammalian tissues, but their impact on the development and growth of these tissues is less clear. For example,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2297e85a19261f9af481fa89b3d70d32
https://europepmc.org/articles/PMC4352814/
https://europepmc.org/articles/PMC4352814/
Publikováno v:
Journal of Biological Chemistry. 278:17130-17140
Homeodomain transcription factor Nkx2.2 is required for the final differentiation of the beta-cells in the pancreas and for the production of insulin. Nkx2.2 is expressed in islet cell precursors during pancreatic development and persists in a subset
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49fff314a056bfb87648edf7798e2cc8
https://doi.org/10.1074/jbc.m213196200
https://doi.org/10.1074/jbc.m213196200
Autor:
François Guillemot, Jeffrey Lee, David W. Scheel, Ying Liu, Yingchuan Qi, Michael S. German, Yuanyuan Wu, Haipeng Xue, Mengsheng Qiu, Mahendra S. Rao
Publikováno v:
Developmental Biology. 253:84-98
To study the role of basic helix–loop–helix (bHLH) transcription factors in gliogenesis, we examined whether bHLH transcription factors were expressed in glial precursor cells and participated in regulating oligodendrocyte and astrocyte developme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14d10e1e318f0572e7ab8709c97bb6a6
https://doi.org/10.1006/dbio.2002.0868
https://doi.org/10.1006/dbio.2002.0868