Zobrazeno 1 - 10
of 164
pro vyhledávání: '"David W. Raible"'
Autor:
Patricia Wu, Francisco Barros-Becker, Roberto Ogelman, Esra D. Camci, Tor H. Linbo, Julian A. Simon, Edwin W. Rubel, David W. Raible
Publikováno v:
Frontiers in Neurology, Vol 15 (2024)
Mechanosensory hair cells of the inner ears and lateral line of vertebrates display heightened vulnerability to environmental insult, with damage resulting in hearing and balance disorders. An important example is hair cell loss due to exposure to to
Externí odkaz:
https://doaj.org/article/b76764b1f3394af9afc2e2e3a2e0f62d
Autor:
Ethan Bustad, Emma Mudrock, Elizabeth M. Nilles, Andrea Mcquate, Monica Bergado, Alden Gu, Louie Galitan, Natalie Gleason, Henry C. Ou, David W. Raible, Rafael E. Hernandez, Shuyi Ma
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Introduction: Ototoxicity is a debilitating side effect of over 150 medications with diverse mechanisms of action, many of which could be taken concurrently to treat multiple conditions. Approaches for preclinical evaluation of drug-drug interactions
Externí odkaz:
https://doaj.org/article/5b337905b38c463383e4f19a5a9a8ec3
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
Ciliated sensory cells such as photo- and olfactory receptors employ multiple types of opsins or hundreds of unique olfactory G-protein coupled receptors to respond to various wavelengths of light or odorants. With respect to hearing and balance, the
Externí odkaz:
https://doaj.org/article/07f619a01b4b4ce48ed8f9a7f06bf85e
Autor:
Selina Baeza-Loya, David W. Raible
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
The vestibular system of the inner ear provides information about head motion and spatial orientation relative to gravity to ensure gaze stability, balance, and postural control. Zebrafish, like humans, have five sensory patches per ear that serve as
Externí odkaz:
https://doaj.org/article/6a3b4bf5d65149f1aba7c431579b7b3a
Autor:
Joseph A. Bellairs, Van A. Redila, Patricia Wu, Ling Tong, Alyssa Webster, Julian A. Simon, Edwin W. Rubel, David W. Raible
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 15 (2022)
There are no approved therapeutics for the prevention of hearing loss and vestibular dysfunction from drugs like aminoglycoside antibiotics. While the mechanisms underlying aminoglycoside ototoxicity remain unresolved, there is considerable evidence
Externí odkaz:
https://doaj.org/article/730d1673827d458f99d9ea120893dffb
Autor:
Tamara M. Stawicki, Tor Linbo, Liana Hernandez, Lauren Parkinson, Danielle Bellefeuille, Edwin W. Rubel, David W. Raible
Publikováno v:
Biology Open, Vol 8, Iss 1 (2019)
Sensory hair cells are susceptible to numerous insults, including certain therapeutic medications like aminoglycoside antibiotics, and hearing and balance disorders are often a dose-limiting side effect of these medications. We show that mutations in
Externí odkaz:
https://doaj.org/article/80419cca077243c1b54d62b6835b8a75
Autor:
Tamara M. Stawicki, Liana Hernandez, Robert Esterberg, Tor Linbo, Kelly N. Owens, Arish N. Shah, Nihal Thapa, Brock Roberts, Cecilia B. Moens, Edwin W. Rubel, David W. Raible
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 6, Iss 7, Pp 2225-2235 (2016)
Hair cells possess a single primary cilium, called the kinocilium, early in development. While the kinocilium is lost in auditory hair cells of most species it is maintained in vestibular hair cells. It has generally been believed that the primary ro
Externí odkaz:
https://doaj.org/article/b1ded0c795714326a4abdfe48d02ce62
Autor:
Takeshi Yoshimatsu, Florence D. D’Orazi, Clare R. Gamlin, Sachihiro C. Suzuki, Arminda Suli, David Kimelman, David W. Raible, Rachel O. Wong
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
Neurons in the zebrafish retina regenerate. Here, Yoshimatsu and colleagues show that retinal horizontal cells maintain their synaptic preferences for a limited period before circuit remodeling is triggered after photoreceptor loss.
Externí odkaz:
https://doaj.org/article/609b3ef2115b451891d572c441383d66
Autor:
Matthew Ryals, Robert J. Morell, Daniel Martin, Erich T. Boger, Patricia Wu, David W. Raible, Lisa L. Cunningham
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 12 (2018)
Mechanosensory hair cells of the inner ear transduce auditory and vestibular sensory input. Hair cells are susceptible to death from a variety of stressors, including treatment with therapeutic drugs that have ototoxic side effects. There is a need f
Externí odkaz:
https://doaj.org/article/8768a529d8e7418aabe65310ea6eb6d2
The zebrafish merovingian mutant reveals a role for pH regulation in hair cell toxicity and function
Autor:
Tamara M. Stawicki, Kelly N. Owens, Tor Linbo, Katherine E. Reinhart, Edwin W. Rubel, David W. Raible
Publikováno v:
Disease Models & Mechanisms, Vol 7, Iss 7, Pp 847-856 (2014)
Control of the extracellular environment of inner ear hair cells by ionic transporters is crucial for hair cell function. In addition to inner ear hair cells, aquatic vertebrates have hair cells on the surface of their body in the lateral line system
Externí odkaz:
https://doaj.org/article/7e2a24f40b6b460795a785482b196dcf