Zobrazeno 1 - 10
of 236
pro vyhledávání: '"David W. Raible"'
Autor:
Patricia Wu, Francisco Barros-Becker, Roberto Ogelman, Esra D. Camci, Tor H. Linbo, Julian A. Simon, Edwin W. Rubel, David W. Raible
Publikováno v:
Frontiers in Neurology, Vol 15 (2024)
Mechanosensory hair cells of the inner ears and lateral line of vertebrates display heightened vulnerability to environmental insult, with damage resulting in hearing and balance disorders. An important example is hair cell loss due to exposure to to
Externí odkaz:
https://doaj.org/article/b76764b1f3394af9afc2e2e3a2e0f62d
Autor:
Ethan Bustad, Emma Mudrock, Elizabeth M. Nilles, Andrea Mcquate, Monica Bergado, Alden Gu, Louie Galitan, Natalie Gleason, Henry C. Ou, David W. Raible, Rafael E. Hernandez, Shuyi Ma
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Introduction: Ototoxicity is a debilitating side effect of over 150 medications with diverse mechanisms of action, many of which could be taken concurrently to treat multiple conditions. Approaches for preclinical evaluation of drug-drug interactions
Externí odkaz:
https://doaj.org/article/5b337905b38c463383e4f19a5a9a8ec3
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
Ciliated sensory cells such as photo- and olfactory receptors employ multiple types of opsins or hundreds of unique olfactory G-protein coupled receptors to respond to various wavelengths of light or odorants. With respect to hearing and balance, the
Externí odkaz:
https://doaj.org/article/07f619a01b4b4ce48ed8f9a7f06bf85e
Autor:
Selina Baeza-Loya, David W. Raible
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
The vestibular system of the inner ear provides information about head motion and spatial orientation relative to gravity to ensure gaze stability, balance, and postural control. Zebrafish, like humans, have five sensory patches per ear that serve as
Externí odkaz:
https://doaj.org/article/6a3b4bf5d65149f1aba7c431579b7b3a
Activity regulates a cell type-specific mitochondrial phenotype in zebrafish lateral line hair cells
Publikováno v:
eLife, Vol 12 (2023)
Hair cells of the inner ear are particularly sensitive to changes in mitochondria, the subcellular organelles necessary for energy production in all eukaryotic cells. There are over 30 mitochondrial deafness genes, and mitochondria are implicated in
Externí odkaz:
https://doaj.org/article/4fd143e6bd184f7fa9c8965550b48f90
Autor:
Tanya L Brown, Emma C Horton, Evan W Craig, Camille EA Goo, Erik C Black, Madeleine N Hewitt, Nathaniel G Yee, Everett T Fan, David W Raible, Jeffrey P Rasmussen
Publikováno v:
eLife, Vol 12 (2023)
Touch system function requires precise interactions between specialized skin cells and somatosensory axons, as exemplified by the vertebrate mechanosensory Merkel cell-neurite complex. Development and patterning of Merkel cells and associated neurite
Externí odkaz:
https://doaj.org/article/512962c3179e40978dacd297b1dd6b5f
Autor:
Tuo Shi, Marielle O Beaulieu, Lauren M Saunders, Peter Fabian, Cole Trapnell, Neil Segil, J Gage Crump, David W Raible
Publikováno v:
eLife, Vol 12 (2023)
A major cause of human deafness and vestibular dysfunction is permanent loss of the mechanosensory hair cells of the inner ear. In non-mammalian vertebrates such as zebrafish, regeneration of missing hair cells can occur throughout life. While a comp
Externí odkaz:
https://doaj.org/article/453e461ae07245579ef96440d47eaab7
Autor:
Joseph A. Bellairs, Van A. Redila, Patricia Wu, Ling Tong, Alyssa Webster, Julian A. Simon, Edwin W. Rubel, David W. Raible
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 15 (2022)
There are no approved therapeutics for the prevention of hearing loss and vestibular dysfunction from drugs like aminoglycoside antibiotics. While the mechanisms underlying aminoglycoside ototoxicity remain unresolved, there is considerable evidence
Externí odkaz:
https://doaj.org/article/730d1673827d458f99d9ea120893dffb
Autor:
Eric D Thomas, David W Raible
Publikováno v:
eLife, Vol 8 (2019)
Mechanosensory hair cells of the zebrafish lateral line regenerate rapidly following damage. These renewed hair cells arise from the proliferation of surrounding support cells, which undergo symmetric division to produce two hair cell daughters. Give
Externí odkaz:
https://doaj.org/article/05b7a1a990c74d7998548bae744847ab
Autor:
Tamara M. Stawicki, Tor Linbo, Liana Hernandez, Lauren Parkinson, Danielle Bellefeuille, Edwin W. Rubel, David W. Raible
Publikováno v:
Biology Open, Vol 8, Iss 1 (2019)
Sensory hair cells are susceptible to numerous insults, including certain therapeutic medications like aminoglycoside antibiotics, and hearing and balance disorders are often a dose-limiting side effect of these medications. We show that mutations in
Externí odkaz:
https://doaj.org/article/80419cca077243c1b54d62b6835b8a75