Zobrazeno 1 - 10 of 21 pro vyhledávání: '"David W. Old"'
2
Aza-Cope Rearrangement−Mannich Cyclizations for the Formation of Complex Tricyclic Amines: Stereocontrolled Total Synthesis of (±)-Gelsemine
Autor: G. Patrick Meier, William G. Earley, Matthew J. Sharp, Taeboem Oh, Andrew Madin, Jon E. Jacobsen, Larry E. Overman, Christopher J. O’Donnell, David W. Old
Publikováno v: Journal of the American Chemical Society. 127:18046-18053
A detailed examination of the use of aza-Cope rearrangement-Mannich cyclization sequences for assembling the azatricyclo[4.4.0.0(2,8)]decane core of gelsemine is described. Iminium ions and N-acyloxyiminium ions derived from endo-oriented 1-methoxy-
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58f04a2d069a1fa6b7d176fd97ec1af5
https://doi.org/10.1021/ja055710p
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3
Use of the Intramolecular Heck Reaction for Forming Congested Quaternary Carbon Stereocenters. Stereocontrolled Total Synthesis of (±)-Gelsemine
Autor: Taeboem Oh, Matthew J. Sharp, Larry E. Overman, Christopher J. O’Donnell, David W. Old, Andrew Madin
Publikováno v: Journal of the American Chemical Society. 127:18054-18065
Intramolecular Heck reactions of alpha,beta-unsaturated 2-haloanilides derived from azatricyclo[4.4.0.0(2,8)]decanone 5 efficiently install the congested spirooxindole functionality of gelsemine. Depending upon the Heck reaction conditions and the na
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0b4cfc37d9d5f3aafe7deb2e22a6ee5
https://doi.org/10.1021/ja055711h
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4
Novel Electron-Rich Bulky Phosphine Ligands Facilitate the Palladium-Catalyzed Preparation of Diaryl Ethers
Autor: David W. Old, Attila Aranyos, and Joseph P. Sadighi, Ayumu Kiyomori, John P. Wolfe, Stephen L. Buchwald
Publikováno v: Journal of the American Chemical Society. 121:4369-4378
A general method for the palladium-catalyzed formation of diaryl ethers is described. Electron-rich, bulky aryldialkylphosphine ligands, in which the two alkyl groups are either tert-butyl or 1-adamantyl, are the key to the success of the transformat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dcc76a63c79695be12d0b5a438edcf24
https://doi.org/10.1021/ja990324r
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5
Asymmetric Synthesis of Cis-Fused Bicyclic Pyrrolidines and Pyrrolidinones via Chiral Polycyclic Lactams
Autor: N. B. Ghazal, Ennis Michael D, David W. Old, Robert Louis Hoffman, Pamela A. Mooney
Publikováno v: The Journal of Organic Chemistry. 61:5813-5817
Condensation of racemic keto-ester 2 and 1.1 equiv of (R)-(−)-phenylglycinol in toluene with azeotropic removal of water and methanol gave rise to a tetracyclic lactam in greater than 90% yield. Examination of the crude reaction product by 1H and 1
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9c9ed3cad49e4724d1d8e4d8e8ee8166
https://doi.org/10.1021/jo960185l
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6
2-(Di-tert-butylphosphino)biphenyl
Autor: David W. Old, John P. Wolfe
Publikováno v: e-EROS Encyclopedia of Reagents for Organic Synthesis
[224311-51-7] C20H27P (MW 298.41) InChI = 1/C20H27P/c1-19(2,3)21(20(4,5)6)18-15-11-10-14-17(18)16-12-8-7-9-13-16/h7-15H,1-6H3 InChIKey = CNXMDTWQWLGCPE-UHFFFAOYAH (reagent used as a ligand for palladium catalysts in a variety of CN, CO, CSi, and CC b
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cb4d9b4b441d20ecc31179afb40b034e
https://doi.org/10.1002/047084289x.rn00134.pub2
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7
ChemInform Abstract: Enzymatic Resolution of 2-Hydroxymethyl-1,4-benzodioxanes
Autor: Michael D. Ennis, David W. Old
Publikováno v: ChemInform. 24
2-Hydroxymethyl-1,4-benzodioxanes have been shown to be effectively resolved through an enzyme-mediated, stereoselective acylation. Enantiomeric excesses greater than 80% are realized after a single acylation, and enriched material can be upgraded to
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::89fcf570a65d0c3cad298a1bb7bd79d4
https://doi.org/10.1002/chin.199309181
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8
ChemInform Abstract: Asymmetric Synthesis of cis-Fused Bicyclic Pyrrolidines and Pyrrolidinones via Chiral Polycyclic Lactams
Autor: Pamela A. Mooney, N. B. Ghazal, Ennis Michael D, Robert Louis Hoffman, David W. Old
Publikováno v: ChemInform. 28
Condensation of racemic keto-ester 2 and 1.1 equiv of (R)-(−)-phenylglycinol in toluene with azeotropic removal of water and methanol gave rise to a tetracyclic lactam in greater than 90% yield. Examination of the crude reaction product by 1H and 1
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2aafa47ab665e1d32a2e34b1acbc8db7
https://doi.org/10.1002/chin.199706117
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10
Prostaglandin E2 receptor subtype EP2- and EP4-regulated gene expression profiling in human ciliary smooth muscle cells
Autor: Yariv Donde, Larry A. Wheeler, Armin Reitmair, Wha Bin Im, Robert M. Burk, George Sachs, David W. Old, Danny T. Dinh, A.L. Nieves, Nils Lambrecht, Iskandar Yakubov
Publikováno v: Physiological genomics. 42(3)
Prostanoids are an important class of intraocular pressure (IOP)-lowering antiglaucoma agents that act primarily via increased uveo-scleral aqueous humor outflow through the ciliary body. We have developed two novel PGE2analogs that are specific agon
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a82033d96adb6c62fdc179f05fd7d2d9
https://pubmed.ncbi.nlm.nih.gov/20551148
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