Zobrazeno 1 - 10
of 137
pro vyhledávání: '"David W. Meek"'
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Abstract The PIM1 serine/threonine protein kinase mediates growth factor and survival signalling, and cooperates potently with c-MYC during tumorigenesis. PIM1 is overexpressed in many human cancers and is a promising target for drug development. PIM
Externí odkaz:
https://doaj.org/article/e921f6e7df054849bf32d4abc8984c40
Supplementary Figures 1-14 from Mage-A Cancer/Testis Antigens Inhibit p53 Function by Blocking Its Interaction with Chromatin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cf11980407ac62d733634b139e42fca
https://doi.org/10.1158/0008-5472.22385280.v1
https://doi.org/10.1158/0008-5472.22385280.v1
The p53 tumor suppressor plays a major protective role in tumor prevention by coordinating changes in gene expression that lead to the elimination of cancer cells. Mage-A proteins comprise a family of metastasis-associated transcriptional regulators
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bb35a8b836e32a276d07fcc2b4d3780
https://doi.org/10.1158/0008-5472.c.6501177
https://doi.org/10.1158/0008-5472.c.6501177
Autor:
Lynnette Marcar, Bianca Ihrig, John Hourihan, Susan E Bray, Philip R Quinlan, Lee B Jordan, Alastair M Thompson, Ted R Hupp, David W Meek
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0127713 (2015)
Melanoma antigen A (MAGE-A) proteins comprise a structurally and biochemically similar sub-family of Cancer/Testis antigens that are expressed in many cancer types and are thought to contribute actively to malignancy. MAGE-A proteins are established
Externí odkaz:
https://doaj.org/article/c3b4f6a5f4cc41249e0423676b0f4cea
Autor:
Anna Estevan, Barber, David W, Meek
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2267
The p53 tumor suppressor has a central role in many key cellular processes including the DNA damage response, aging, stem cell differentiation, and fertility. p53 undergoes extensive regulatory post-translational modification through events such as p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::51263eb7bec0f07f012104570cfce912
https://pubmed.ncbi.nlm.nih.gov/33786782
https://pubmed.ncbi.nlm.nih.gov/33786782
Autor:
David W. Meek, Anna Estevan Barber
Publikováno v:
Cell Cycle Checkpoints ISBN: 9781071612163
The p53 tumor suppressor has a central role in many key cellular processes including the DNA damage response, aging, stem cell differentiation, and fertility. p53 undergoes extensive regulatory post-translational modification through events such as p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b4c76843d6e19978b5478697b6cff981
https://doi.org/10.1007/978-1-0716-1217-0_2
https://doi.org/10.1007/978-1-0716-1217-0_2
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-1 (2018)
The original version of this Article contained a typographical error in the spelling of the author Adrian T. Saurin, which was incorrectly given as Adrian Saurin. This has now been corrected in the PDF and HTML versions of the Article, and in the acc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3696a97aa78b2416a26c72bb374c23b8
https://doi.org/10.1038/s41598-018-23384-5
https://doi.org/10.1038/s41598-018-23384-5
Autor:
Frances V. Fuller-Pace, Manikandan Periyasamy, David W. Meek, Hetal Patel, Holly B. Kramer, Stephan M. Feller, Laki Buluwela, Chun-Fui Lai, Meng-Lay Lin, Simak Ali
Publikováno v:
Nucleic Acids Research
Liver receptor homologue 1 (LRH-1) is an orphan nuclear receptor that has been implicated in the progression of breast, pancreatic and colorectal cancer (CRC). To determine mechanisms underlying growth promotion by LRH-1 in CRC, we undertook global e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29bf4e48bdaeb99e862efeb8455454b4
https://doi.org/10.1093/nar/gkv948
https://doi.org/10.1093/nar/gkv948
Publikováno v:
Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Polo-like kinase-1 (PLK1) plays a major role in driving mitotic events, including centrosome disjunction and separation, and is frequently over-expressed in human cancers. PLK1 inhibition is a promising therapeutic strategy and works by arresting cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d51ef108f5cde0372e3488b678b54fa
http://europepmc.org/articles/PMC5701047
http://europepmc.org/articles/PMC5701047
Autor:
Manikandan, Periyasamy, Anup K, Singh, Carolina, Gemma, Christian, Kranjec, Raed, Farzan, Damien A, Leach, Naveenan, Navaratnam, Hajnalka L, Pálinkás, Beata G, Vértessy, Tim R, Fenton, John, Doorbar, Frances, Fuller-Pace, David W, Meek, R Charles, Coombes, Laki, Buluwela, Simak, Ali
Publikováno v:
Nucleic Acids Research
Cancer genome sequencing has implicated the cytosine deaminase activity of apolipoprotein B mRNA editing enzyme catalytic polypeptide-like (APOBEC) genes as an important source of mutations in diverse cancers, with APOBEC3B (A3B) expression especiall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::08237487eb154c3b1b84f6bb9c3f6211
https://pubmed.ncbi.nlm.nih.gov/28977491
https://pubmed.ncbi.nlm.nih.gov/28977491