Zobrazeno 1 - 10
of 16
pro vyhledávání: '"David W. McKellar"'
Autor:
Andrea Flesken-Nikitin, Coulter Q. Ralston, Dah-Jiun Fu, Andrea J. De Micheli, Daryl J. Phuong, Blaine A. Harlan, Christopher S. Ashe, Amanda P. Armstrong, David W. McKellar, Sangeeta Ghuwalewala, Lora H. Ellenson, John C. Schimenti, Benjamin D. Cosgrove, Alexander Yu. Nikitin
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract The distal region of the uterine (Fallopian) tube is commonly associated with high-grade serous carcinoma (HGSC), the predominant and most aggressive form of ovarian or extra-uterine cancer. Specific cell states and lineage dynamics of the a
Externí odkaz:
https://doaj.org/article/90512a4f897946e0b160380da2b3bd0c
Autor:
Alessandra M. Norris, Ambili Bai Appu, Connor D. Johnson, Lylybell Y. Zhou, David W. McKellar, Marie-Ange Renault, David Hammers, Benjamin D. Cosgrove, Daniel Kopinke
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Successful muscle regeneration relies on the interplay of multiple cell populations. However, the signals required for this coordinated intercellular crosstalk remain largely unknown. Here, we describe how the Hedgehog (Hh) signaling pathway
Externí odkaz:
https://doaj.org/article/e825d6420a8846a289d38a1d5eb31866
Autor:
David W. McKellar, Lauren D. Walter, Leo T. Song, Madhav Mantri, Michael F. Z. Wang, Iwijn De Vlaminck, Benjamin D. Cosgrove
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
David McKellar et al. integrate single-cell and -nuclear transcriptomic analyses of mouse skeletal muscle in homeostatic conditions or following injury. The resulting transcriptomic model of myogenesis identified rare, transitional states and cell su
Externí odkaz:
https://doaj.org/article/c4f3d62d830e41acb90880a9b21a949c
Autor:
Umji Lee, Pascal Stuelsatz, Sonia Karaz, David W. McKellar, Julie Russeil, Maria Deak, Iwijn De Vlaminck, Christoph Lepper, Bart Deplancke, Benjamin D. Cosgrove, Jerome N. Feige
Publikováno v:
iScience, Vol 25, Iss 7, Pp 104589- (2022)
Summary: Apelin (Apln) is a myokine that regulates skeletal muscle plasticity and metabolism and declines during aging. Through a yeast one-hybrid transcription factor binding screen, we identified the TEA domain transcription factor 1 (Tead1) as a n
Externí odkaz:
https://doaj.org/article/5b78ad39c82e4e3080f88739f302cb31
Autor:
Michael F. Z. Wang, Madhav Mantri, Shao-Pei Chou, Gaetano J. Scuderi, David W. McKellar, Jonathan T. Butcher, Charles G. Danko, Iwijn De Vlaminck
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Conventional single-cell RNA sequencing analysis rely on genome annotations that may be incomplete or inaccurate especially for understudied organisms. Here the authors present a bioinformatic tool that leverages single-cell data to uncover biologica
Externí odkaz:
https://doaj.org/article/61a7bc13e77e42f98fc57182ea58774c
Autor:
David W. McKellar, Madhav Mantri, Meleana M. Hinchman, John S. L. Parker, Praveen Sethupathy, Benjamin D. Cosgrove, Iwijn De Vlaminck
Publikováno v:
Nature Biotechnology. 41:513-520
Spatial transcriptomics reveals the spatial context of gene expression, but current methods are limited to assaying polyadenylated (A-tailed) RNA transcripts. Here we demonstrate that enzymatic in situ polyadenylation of RNA enables detection of the
Autor:
Alessandra M. Norris, Connor D. Johnson, Lylybell Y. Zhou, Ambili Appu, David W. McKellar, Benjamin D. Cosgrove, Daniel Kopinke
Failed tissue regeneration often results in fatty fibrosis, the replacement of healthy cells with fibrotic scar and fat tissue. However, the causative signals remain largely unknown. Here, we describe how the Hedgehog (Hh) signaling pathway controls
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1006c9d206e2ae2c1a60806ef848dc0b
https://doi.org/10.1101/2022.08.15.504012
https://doi.org/10.1101/2022.08.15.504012
Autor:
Charles G. Danko, Gaetano J. Scuderi, Michael F. Z. Wang, Iwijn De Vlaminck, Madhav Mantri, David W. McKellar, Jonathan T. Butcher, Shao-Pei Chou
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Nature Communications
Nature Communications
Conventional scRNA-seq expression analyses rely on the availability of a high quality genome annotation. Yet, as we show here with scRNA-seq experiments and analyses spanning human, mouse, chicken, mole rat, lemur and sea urchin, genome annotations a
Autor:
David W. McKellar, Madhav Mantri, Meleana Hinchman, John S.L. Parker, Praveen Sethupathy, Benjamin D. Cosgrove, Iwijn De Vlaminck
Spatial transcriptomics reveals the spatial context of gene expression, but current methods are limited to assaying polyadenylated (A-tailed) RNA transcripts. Here we demonstrate that enzymatic in situ polyadenylation of RNA enables detection of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e0add1ad20ea050f1f0594a2dc6b342b
https://doi.org/10.1101/2022.04.20.488964
https://doi.org/10.1101/2022.04.20.488964
Autor:
Madhav Mantri, Benjamin D. Cosgrove, Leo T. Song, Lauren D. Walter, David W. McKellar, Iwijn De Vlaminck, Michael F. Z. Wang
Publikováno v:
Communications Biology
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
Skeletal muscle repair is driven by the coordinated self-renewal and fusion of myogenic stem and progenitor cells. Single-cell gene expression analyses of myogenesis have been hampered by the poor sampling of rare and transient cell states that are c