Zobrazeno 1 - 10
of 13
pro vyhledávání: '"David W. McClymont"'
Autor:
Lorna Suckling, Ciaran McFarlane, Chelsea Sawyer, Stephen P. Chambers, Richard I. Kitney, David W. McClymont, Paul S. Freemont
Publikováno v:
Synthetic and Systems Biotechnology, Vol 4, Iss 1, Pp 57-66 (2019)
High-throughput preparation of plasmid DNA libraries for next-generation sequencing (NGS) is an important capability for molecular biology laboratories. In particular, it is an essential quality control (QC) check when large numbers of plasmid varian
Externí odkaz:
https://doaj.org/article/e31301f7e061421490a5492bc49c5fe5
Autor:
Richard I. Kitney, Stephen P. Chambers, Lorna Suckling, David W. McClymont, Ciaran McFarlane, Paul S. Freemont, Chelsea Sawyer
Publikováno v:
Synthetic and Systems Biotechnology, Vol 4, Iss 1, Pp 57-66 (2019)
Synthetic and Systems Biotechnology
Synthetic and Systems Biotechnology
High-throughput preparation of plasmid DNA libraries for next-generation sequencing (NGS) is an important capability for molecular biology laboratories. In particular, it is an essential quality control (QC) check when large numbers of plasmid varian
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf5b4e1c60468b219a40811c91e2bde2
https://doi.org/10.1016/j.synbio.2019.01.002
https://doi.org/10.1016/j.synbio.2019.01.002
Autor:
David W. McClymont, Derek Bell, David G. Tew, Marcelo Kern, Glen-Oliver F. Gowers, Soo Mei Chee, Tom Ellis, Lorna Suckling
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-7 (2020)
Nature Communications
Nature Communications
Synthetic biology, genome engineering and directed evolution offer innumerable tools to expedite engineering of strains for optimising biosynthetic pathways. One of the most radical is SCRaMbLE, a system of inducible in vivo deletion and rearrangemen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b024bb18d731eba3425107e5a221462b
http://hdl.handle.net/10044/1/77035
http://hdl.handle.net/10044/1/77035
Autor:
Caoimhe Canavan, Velia Siciliano, Bruno Goetzmann, David W. McClymont, Michael A. Crone, James M. MacDonald, Paul S. Freemont, M. Kopniczky, Lorna Suckling, Kirsten Jensen
Publikováno v:
ACS synthetic biology. 9(1)
The field of mammalian synthetic biology is expanding quickly, and technologies for engineering large synthetic gene circuits are increasingly accessible. However, for mammalian cell engineering, traditional tissue culture methods are slow and cumber
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f341c97f791bc7f0e1a7f04e3f85375
https://pubmed.ncbi.nlm.nih.gov/31899623
https://pubmed.ncbi.nlm.nih.gov/31899623
Autor:
Jørn Skavland, Sonia Gavasso, Bjørn Tore Gjertsen, David W. McClymont, Lucius Bader, Stein-Erik Gullaksen, André Sulen
Publikováno v:
Pharmacological Research. 113:216-227
Hydrogen sulfide (H2S) is an endogenous gasotransmitter in human physiology and inflammatory disease, however, with limited knowledge of how signal transduction pathways are involved in immune cells. To examine the effects of sulfide on relevant intr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bab179af972ccb025aff9c349972841
https://doi.org/10.1016/j.phrs.2016.08.018
https://doi.org/10.1016/j.phrs.2016.08.018
Autor:
A. Foster, Paul S. Freemont, Lorna Suckling, Richard I. Kitney, Priscilla D. Rajakumar, David W. McClymont, Tom Ellis, G-O. F. Gowers
Publikováno v:
SLAS technology. 24(3)
Biofoundries have enabled the ability to automate the construction of genetic constructs using computer-aided design. In this study, we have developed the methodology required to abstract and automate the construction of yeast-compatible designs. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed8fba796eabef59117e5714c88a84dc
https://pubmed.ncbi.nlm.nih.gov/30165777
https://pubmed.ncbi.nlm.nih.gov/30165777
Autor:
Sarah Weinecke, Simon J. Moore, Alka Ishwarbhai, Rochelle Aw, Paul S Freemont, James M. MacDonald, Karen M. Polizzi, David W. McClymont, David J. Bell, Kirsten Jensen, Rebekka Biedendieck, Nicolas Kylilis, Argyro Tsipa
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
E4349
E4340
E4349
E4340
Significance Nonmodel bacteria have essential roles to play in the future development of biotechnology by providing new sources of biocatalysts, antibiotics, hosts for bioproduction, and engineered “living therapies.” The characterization of such
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42452173a3c4891911cb97b9bbb3886a
http://ora.ox.ac.uk/objects/uuid:
http://ora.ox.ac.uk/objects/uuid:
Autor:
Paul S. Freemont, David W. McClymont
Publikováno v:
Nature biotechnology. 35(4)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f34d77b464b5878ca810195d07280ee
https://pubmed.ncbi.nlm.nih.gov/28398329
https://pubmed.ncbi.nlm.nih.gov/28398329
Connexin 43 (Cx43), the predominant gap junction (GJ) protein, directly interacts with the A-kinase-anchoring protein (AKAP) Ezrin in human cytotrophoblasts and a rat liver epithelial cells (IAR20). The Cx43-Ezrin–protein kinase (PKA) complex facil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd7da6e8e42156f8d0aa0bfb8b2112a3
http://hdl.handle.net/10852/65202
http://hdl.handle.net/10852/65202
Autor:
Maria Laura Bolognesi, Ian R. Mellor, José Marco-Contelles, Elena Simoni, Michela Rosini, Barbara Monti, Vincenza Andrisano, Manuela Bartolini, David W. McClymont, Elena Soriano, Birgit Hutter-Paier, Manfred Windisch
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
Inspired by the concept of bivalent ligands, we prepared a small set of analogues of the drug candidate dimebon. They were shown to inhibit AChE, Aβ42 aggregation, and NMDA receptor activation to a greater extent than dimebon. Some of these compound
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e511551adcbeb4d24a671bca5a2b2138
http://hdl.handle.net/10261/114915
http://hdl.handle.net/10261/114915