Zobrazeno 1 - 10
of 32
pro vyhledávání: '"David W. Lancki"'
Publikováno v:
Seminars in Immunology. 20:228-235
Considerable progress is being achieved in the analysis of gene regulatory networks that direct cell fate decisions within the hematopoietic system. In addition to transcription factors that are pivotal for cell fate specification and commitment, rec
Autor:
Thomas Treiber, Eric Bertolino, Daniel L. Northrup, Rudolf Grosschedl, Kay L. Medina, Matthew Thomas, David Allman, Jagan M. R. Pongubala, Harinder Singh, David W. Lancki
Publikováno v:
Nature Immunology
Alternative lineage restriction and B cell fate commitment require the transcription factor Pax5, but the function of early B cell factor (EBF) in these processes remains mostly unexplored. Here we show that in the absence of EBF, 'expandable' and cl
Autor:
Matthias Kieslinger, Rodney P. DeKoter, Kay L. Medina, Jagan M. R. Pongubala, David W. Lancki, Karen L. Reddy, Harinder Singh, Rudolf Grosschedl
Publikováno v:
Developmental Cell
The generation of B lymphocyte precursors is dependent on the combinatorial action of the transcription factors PU.1, Ikaros, E2A, EBF, and Pax-5. Loss of PU.1 results in a severe reduction in Flk2+, IL-7R+ lymphoid progenitors as well as impaired ex
Autor:
M. Celeste Simon, Sangeeta R. Iyer, Peter Laslo, Jonathan C Walsh, David W. Lancki, Richard Dahl, Harinder Singh
Publikováno v:
Nature Immunology. 4:1029-1036
Hematopoietic transcription factors are essential for specifying cell fates; however, the function of cytokines in such developmental decisions is unresolved. We demonstrate here that haploinsufficiency for the gene encoding the transcription factor
Publikováno v:
Genes & Development. 17:1703-1708
B-lymphocyte development involves sequential DNA rearrangements of immunoglobulin (Ig) heavy (μ) and light (κ, λ) chain loci and is dependent on transient expression of μ containing pre-antigen receptor complexes (pre-BCR). To date, genetic analy
Autor:
Daniel S. Friend, Michael F. Gurish, Richard L. Stevens, Harinder Singh, Rodney P. DeKoter, John Anastasi, Erica D. Smith, David W. Lancki, Hyun Jun Lee, Jonathan C Walsh
Publikováno v:
Immunity. 17:665-676
PU.1 and GATA transcription factors appear to antagonize each other's function in the development of distinct lineages of the hematopoietic system. In contrast, we demonstrate that PU.1, like GATA-2, is essential for the generation of mast cells. PU.
Publikováno v:
Immunological Reviews. 146:117-144
The OVA-reactive CD4 + Thl clones and alloreactive CD8 + clones derived from wild-type or fyn -l- mice serve as model systems which have allowed us to investigate several aspects of the molecular events associated with T cell-mediated cytotoxicity, i
Publikováno v:
The Journal of Experimental Medicine
Mature CD4+ helper T lymphocytes have been categorized into two major functional phenotypes, TH1 and TH2, which produce distinct arrays of lymphokines and which are thought to arise from a pluripotential precursor cell termed TH0. Clonal anergy can b
Publikováno v:
Annual Review of Immunology. 11:29-48
Signaling pathways in T lymphocytes have been incompletely characterized. It is evident that differences exist among the T cell subsets. We have defined several distinct mechanisms that affect differentially the activities of murine T lymphocyte clon
Autor:
Eric Bertolino, Jagan M. R. Pongubala, Daniel L. Northrup, Rudolf Grosschedl, David W. Lancki, David Allman, Matthew L. Thomas, Harinder Singh, Thomas Treiber, Kay L. Medina
Publikováno v:
The FASEB Journal. 22