Výsledky vyhledávání - "David W. Lafleur"

Data from Preclinical Efficacy of BCMA-Directed CAR T Cells Incorporating a Novel D Domain Antigen Recognition Domain

Autor: David M. Hilbert, Laura K. Richman, David A. Tice, David W. LaFleur, Ankit Gupta, Alexandra R. Witter, Liubov Zaritskaya, Justin P. Edwards, Janine M. Buonato

Chimeric antigen receptor (CAR) T-cell therapies directed against B-cell maturation antigen (BCMA) have shown compelling clinical activity and manageable safety in subjects with relapsed and refractory multiple myeloma (RRMM). Prior reported CAR T ce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71900aff4b530f83223fd73889180fb3
https://doi.org/10.1158/1535-7163.c.6543447

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Chimeric Antigen Receptors Incorporating D Domains Targeting CD123 Direct Potent Mono- and Bi-specific Antitumor Activity of T Cells

Autor: C. Jenny Mu, Justin P. Edwards, Haiying Qin, David M. Hilbert, David W. Lafleur, Terry J. Fry, Ankit Gupta, Liubov Zaritskaya

Publikováno v: Mol Ther

Chimeric antigen receptor (CAR) T cell therapies have demonstrated impressive initial response rates in hematologic malignancies. However, relapse rates are significant, and robust efficacies in other indications, such as solid tumors, will likely re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::097320cc5c608b744c15f89c17854114
https://doi.org/10.1016/j.ymthe.2019.04.010

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Preclinical Efficacy of BCMA-Directed CAR T Cells Incorporating a Novel D Domain Antigen Recognition Domain

Autor: Janine M. Buonato, Justin P. Edwards, Liubov Zaritskaya, Alexandra R. Witter, Ankit Gupta, David W. LaFleur, David A. Tice, Laura K. Richman, David M. Hilbert

Publikováno v: Molecular cancer therapeutics. 21(7)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb685885f4ac887da7dac72d8c7dbbf0
https://pubmed.ncbi.nlm.nih.gov/35737298

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Abstract 601: Chimeric antigen receptors incorporating novel binding domains targeting CD123 direct potent antitumor activity of T cells: Correlation between affinity and activity

Autor: Terry J. Fry, Haiying Qin, David W. Lafleur, C. Jenny Mu, Laura K. Richman, Justin P. Edwards, Ankit Gupta, David M. Hilbert, Liubov Zaritskaya

Publikováno v: Cancer Research. 80:601-601

Unlike the tumor targets associated with initial CAR T cell successes, the vast majority of tumor associated antigens are not unique, but rather expressed at elevated levels compared to normal tissue. For example, while CD123 is overexpressed on many

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::553b1a90cecbdd0884bf253ad1b3d871
https://doi.org/10.1158/1538-7445.am2020-601

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Abstract 1549: ACLX-001, a novel BCMA-targeted CAR-T cell therapy that can be activated, silenced, and reprogrammed in vivo with soluble protein adapters in a dose dependent manner

Autor: David A. Tice, Jeffrey S. Swers, Justin P. Edwards, Sinnie Ng, David M. Hilbert, Haiyan Wang, David W. Lafleur, Samantha McCullough, Janine M Buonato, Liubov Zaritskaya, Ankit Gupta, Jenny Mu

Publikováno v: Cancer Research. 81:1549-1549

Genetically engineered T cells have demonstrated great promise in the treatment of hematologic malignancies including Acute Lymphocytic Leukemia, Non-Hodgkin's lymphoma, and Multiple Myeloma. However, those achievements are often associated with unco

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::713cc4839e297f93bb76b7014923b9d7
https://doi.org/10.1158/1538-7445.am2021-1549

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Selective targeting of HER2-overexpressing solid tumors with a next-generation CAR-T cell therapy

Autor: Liubov Zaritskaya, Ankit Gupta, David M. Hilbert, Jeffrey Swers, Jenny Mu, Justin P. Edwards, Laura Richman, David W. Lafleur

Publikováno v: Journal of Clinical Oncology. 38:3041-3041

3041 Background: Conventional chimeric antigen receptor T cell (CAR-T) therapies have achieved limited clinical success in the treatment of solid tumors, in part due to the challenges of identifying tumor antigen(s) that are uniquely expressed on tum

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8b23fca6c8751a937dcda8fb5d7c5aea
https://doi.org/10.1200/jco.2020.38.15_suppl.3041

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