Zobrazeno 1 - 7
of 7
pro vyhledávání: '"David W. Harshaw"'
Autor:
David W. Harshaw, Steven M. Albelda, Aron B. Fisher, Irina V. Balyasnikova, Melpo Christofidou-Solomidou, Vladimir R. Muzykantov, Linda B. Schultz
Publikováno v:
Proceedings of the National Academy of Sciences. 96:2379-2384
Conjugation of drugs with antibodies to surface endothelial antigens is a potential strategy for drug delivery to endothelium. We studied antibodies to platelet-endothelial adhesion molecule 1 (PECAM-1, a stably expressed endothelial antigen) as carr
Skin flap closure by dermal laser soldering: A wound healing model for sutureless hypospadias repair
Autor:
David W. Harshaw, Douglas A. Canning, Andrew J. Kirsch, John W. Duckett, Edward J. Macarak, Howard M. Snyder, Stephen A. Zderic, Pamela S. Howard
Publikováno v:
Urology. 50:263-272
Laser tissue soldering (LTS) with the diode laser and human albumin-hyaluronate-indocyanine green solder is a safe and effective method of providing an immediate leak-free closure during hypospadias repair. In this report, we compare the physiology,
Autor:
Douglas B. Cines, Lauren Koniaris, Melpo Christofidou-Solomidou, Vladimir R. Muzykantov, Steven M. Albelda, Silvia Muro, David W. Harshaw, D. Neil Granger, Juan-Carlos Murciano
Publikováno v:
Blood. 101(10)
Drug targeting to a highly expressed, noninternalizable determinant up-regulated on the perturbed endothelium may help to manage inflammation and thrombosis. We tested whether inter-cellular adhesion molecule-1 (ICAM-1) targeting is suitable to deliv
Autor:
Simon C. Watkins, Melpo Christofidou-Solomidou, Vladimir R. Muzykantov, Elliott Haut, Juan Carlos Murciano, Sean Alder, Marian T. Nakada, Steven M. Albelda, Rainer Wiewrodt, Jonathan J. Rome, David W. Harshaw, Arnaud Scherpereel
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 300(3)
Therapeutic molecules conjugated with antibodies to the platelet-endothelial cell adhesion molecule-1 (PECAM-1) accumulate in the pulmonary endothelium after i.v. injection in mice. In this study, we characterized PECAM-directed targeting to the lung
Autor:
Douglas B. Cines, Vladimir R. Muzykantov, Aron B. Fisher, David G. Neschis, Michael A. Golden, David W. Harshaw, Marian T. Nakada, Sandra Medinilla, Lauren Koniaris, Khalil Bdeir, Juan-Carlos Murciano
Publikováno v:
American journal of physiology. Lung cellular and molecular physiology. 282(3)
Using tracings of125I-labeled fibrin(ogen) in rodents, we examined the hypothesis that platelets impede the lysis of pulmonary emboli.125I-Microemboli (ME, 3–10 micron diameter) lodged homogeneously throughout the lungs after intravenous injection
Autor:
Katarina Pauls, Timothy McDonald, Folker E. Franke, Sergei M. Danilov, Vitaly D. Gavrilyuk, Vladimir R. Muzykantov, David W. Harshaw, David J. Miletich
Publikováno v:
American journal of physiology. Lung cellular and molecular physiology. 280(6)
Vascular immunotargeting is a mean for a site-selective delivery of drugs and genes to endothelium. In this study, we compared recognition of pulmonary and systemic vessels in rats by candidate carrier monoclonal antibodies (MAbs) to endothelial anti
Autor:
David W. Harshaw, Evgenia Arguiris, Giuseppe G. Pietra, Steven M. Albelda, Melpo Christofidou-Solomidou, Vladimir R. Muzykantov, Garret A. FitzGerald, Charalambos C. Solomides
Publikováno v:
American journal of physiology. Lung cellular and molecular physiology. 278(4)
Vascular immunotargeting is a novel approach for site-selective drug delivery to endothelium. To validate the strategy, we conjugated glucose oxidase (GOX) via streptavidin with antibodies to the endothelial cell surface antigen platelet endothelial