Výsledky vyhledávání - "David W. H. Riches"

Akademický článek

449 Progression of silica-induced pulmonary fibrosis is arrested after selective ablation of Col1a1+ fibroblasts

Autor: Daniel G Foster, Nomin Javkhlan, Jasmine Wilson, Benjamin L. Edelman, David W. H. Riches, Elizabeth F. Redente

Publikováno v: Journal of Clinical and Translational Science, Vol 7, Pp 133-134 (2023)

OBJECTIVES/GOALS: Silicosis is a highly fatal progressive fibrotic disease of the lungs characterized by accumulation and persistence of fibroblasts that excessively deposit Collagen1a1. We sought to eliminate Collagen1a1-expressing fibroblasts throu

Externí odkaz: https://doaj.org/article/5fc1681d4c9945b19ea82670e716be67

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Alveolar epithelial cells and microenvironmental stiffness synergistically drive fibroblast activation in three-dimensional hydrogel lung models

Autor: Thomas Caracena, Rachel Blomberg, Rukshika S. Hewawasam, Zoe E. Fry, David W. H. Riches, Chelsea M. Magin

Publikováno v: Biomaterials Science. 10:7133-7148

Idiopathic pulmonary fibrosis (IPF) is a devastating lung disease that progressively and irreversibly alters the lung parenchyma, eventually leading to respiratory failure. The study of this disease has been historically challenging due to the myriad

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89a0457556f5aa26de5decb451e93f3e
https://doi.org/10.1039/d2bm00827k

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Engineering Hybrid-Hydrogels Comprised of Healthy or Diseased Decellularized Extracellular Matrix to Study Pulmonary Fibrosis

Autor: Kamiel S. Saleh, Rukshika Hewawasam, Predrag Šerbedžija, Rachel Blomberg, Saif E. Noreldeen, Benjamin Edelman, Bradford J. Smith, David W. H. Riches, Chelsea M. Magin

Publikováno v: Cell Mol Bioeng

Idiopathic pulmonary fibrosis is a chronic disease characterized by progressive lung scarring that inhibits gas exchange. Evidence suggests fibroblast-matrix interactions are a prominent driver of disease. However, available preclinical models limit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::486ffa54c942d9eb467e02180088efa2
https://europepmc.org/articles/PMC9700547/

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New Insights into Clinical and Mechanistic Heterogeneity of the Acute Respiratory Distress Syndrome: Summary of the Aspen Lung Conference 2021

Autor: Thomas R. Martin, Rachel L. Zemans, Lorraine B. Ware, Eric P. Schmidt, David W. H. Riches, Lisa Bastarache, Carolyn S. Calfee, Tushar J. Desai, Susanne Herold, Catherine L. Hough, Mark R. Looney, Michael A. Matthay, Nuala Meyer, Samir M. Parikh, Troy Stevens, B. Taylor Thompson

Publikováno v: Am J Respir Cell Mol Biol

Clinical and molecular heterogeneity are common features of human disease. Understanding the basis for heterogeneity has led to major advances in therapy for many cancers and pulmonary diseases such as cystic fibrosis and asthma. Although heterogenei

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::424cf0e8c152886ab2c922b76deecc79
https://europepmc.org/articles/PMC9447141/

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Persistent, Progressive Pulmonary Fibrosis and Epithelial Remodeling in Mice

Autor: Ali N. Bahadur, Bart P. Black, David A. Lynch, Elizabeth F. Redente, David W. H. Riches, Rachel L. Zemans, Stephen M. Humphries, Donald S. Backos, Rubin M. Tuder

Publikováno v: Am J Respir Cell Mol Biol

Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic interstitial lung disease with underlying mechanisms that have been primarily investigated in mice after intratracheal instillation of a single dose of bleomycin. However, the model has si

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1715ca01e8a26116a44cfb26d6af803
https://pubmed.ncbi.nlm.nih.gov/33406369

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Loss of Fas signaling in fibroblasts impairs homeostatic fibrosis resolution and promotes persistent pulmonary fibrosis

Autor: Bart P. Black, Max A. Seibold, Ben L. Edelman, Satria Sajuthi, Sangeeta Chakraborty, Elizabeth F. Redente, David W. H. Riches

Publikováno v: JCI Insight, Vol 6, Iss 1 (2021)
JCI Insight

Idiopathic pulmonary fibrosis (IPF) is a progressive, irreversible fibrotic disease of the distal lung alveoli that culminates in respiratory failure and reduced lifespan. Unlike normal lung repair in response to injury, IPF is associated with the ac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1efed6fef70d5434e4dde078218de699
https://doi.org/10.1172/jci.insight.141618

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Loss of Fas-signaling in pro-fibrotic fibroblasts impairs homeostatic fibrosis resolution and promotes persistent pulmonary fibrosis

Autor: Max A. Seibold, Sangeeta Chakraborty, Bart P. Black, Satria Sajuthi, Benjamin L. Edelman, Elizabeth F. Redente, David W. H. Riches

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c86dca8e843f42cf2fe2c1323c73bab7
https://doi.org/10.1101/2020.08.18.255869

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Protein Tyrosine Phosphatase-N13 Promotes Myofibroblast Resistance to Apoptosis in Idiopathic Pulmonary Fibrosis

Autor: David W. H. Riches, Andrew Thorburn, Alison Bamberg, Steve D. Groshong, Stijn De Langhe, Murry W. Wynes, Bart P. Black, Rubin M. Tuder, Luis A. Ortiz, Douglas Curran-Everett, Gregory P. Cosgrove, Elizabeth F. Redente, Rebecca C. Keith, Carlyne D. Cool, Benjamin L. Edelman

Publikováno v: American Journal of Respiratory and Critical Care Medicine. 198:914-927

Idiopathic pulmonary fibrosis (IPF) is a progressive, fibrotic interstitial lung disease characterized by (myo)fibroblast accumulation and collagen deposition. Resistance to Fas-induced apoptosis is thought to facilitate (myo)fibroblast persistence i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cd75e2038aede8be5471a960260242c
https://doi.org/10.1164/rccm.201707-1497oc

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Overview of Innate Lung Immunity and Inflammation

Autor: David W H, Riches, Thomas R, Martin

Publikováno v: Methods in molecular biology (Clifton, N.J.). 1809

The nasal passages, conducting airways and gas-exchange surfaces of the lung, are constantly exposed to substances contained in the air that we breathe. While many of these suspended substances are relatively harmless, some, for example, pathogenic m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::edda331843d9584efb85743a57214ba7
https://pubmed.ncbi.nlm.nih.gov/29987779

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Nintedanib reduces pulmonary fibrosis in a model of rheumatoid arthritis-associated interstitial lung disease

Autor: David A. Lynch, Ali N. Bahadur, Elizabeth F. Redente, Stephen M. Humphries, Benjamin L. Edelman, Martin A. Aguilar, Bart P. Black, David W. H. Riches, Lutz Wollin

Rheumatoid arthritis (RA)-associated interstitial lung disease (RA-ILD) develops in ~20% of patients with RA. SKG mice, which are genetically prone to development of autoimmune arthritis, develop a pulmonary interstitial pneumonia that resembles huma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6289e875936b0dbbfa435b4778aaf74a
https://europepmc.org/articles/PMC6335004/

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