Zobrazeno 1 - 10
of 289
pro vyhledávání: '"David W. Grainger"'
Autor:
Mitsuyoshi Nakao, Makoto Matsui, Kyungsook Kim, Nobuhiro Nishiyama, David W. Grainger, Teruo Okano, Hideko Kanazawa, Kenichi Nagase
Publikováno v:
Stem Cell Research & Therapy, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Background Human umbilical cord-derived mesenchymal stem cell (hUC-MSC) sheets have recently attracted attention as an alternative approach to injected cell suspensions for stem cell therapy. However, cell engraftment and cytokine expression
Externí odkaz:
https://doaj.org/article/28612099fab3433ba9b9fe1f95d5d0db
Autor:
Sumako Kameishi, Celia M. Dunn, Masatoshi Oka, Kyungsook Kim, Yun-Kyoung Cho, Sun U. Song, David W. Grainger, Teruo Okano
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Allogeneic “off-the-shelf” mesenchymal stem/stromal cell (MSC) therapy requires scalable, quality-controlled cell manufacturing and distribution systems to provide clinical-grade products using cryogenic cell banking. However, previous s
Externí odkaz:
https://doaj.org/article/e91a99820aa44a069683ec20c6c93603
Autor:
Hallie Thorp, Kyungsook Kim, Sophia Bou-Ghannam, Makoto Kondo, Travis Maak, David W. Grainger, Teruo Okano
Publikováno v:
Regenerative Therapy, Vol 18, Iss , Pp 487-496 (2021)
Advanced tissue engineering approaches for direct articular cartilage replacement in vivo employ mesenchymal stem cell (MSC) sources, exploiting innate chondrogenic potential to fabricate hyaline-like constructs in vitro within three-dimensional (3D)
Externí odkaz:
https://doaj.org/article/e3e2a85b4c104a94a2a41d7f88aab775
Autor:
Makoto Kondo, Sumako Kameishi, Kyungsook Kim, Nicolas F. Metzler, Travis G. Maak, Douglas T. Hutchinson, Angela A. Wang, Miki Maehara, Masato Sato, David W. Grainger, Teruo Okano
Publikováno v:
npj Regenerative Medicine, Vol 6, Iss 1, Pp 1-11 (2021)
Abstract Knee cartilage does not regenerate spontaneously after injury, and a gold standard regenerative treatment algorithm has not been established. This study demonstrates preclinical safety and efficacy of scaffold-free, human juvenile cartilage-
Externí odkaz:
https://doaj.org/article/6fdca4955f2f4d8a870ee72a723a6dba
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Mesenchymal stem cells (MSCs) secrete paracrine factors that play crucial roles during tissue regeneration. An increasing body of evidence suggests that this paracrine function is enhanced by MSC cultivation in three-dimensional (3D) tissue-
Externí odkaz:
https://doaj.org/article/f2eaceb8ac6043cdb8dc2f9fddbe681f
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-19 (2021)
Abstract Polyethylene terephthalate (PET) fibers and fabrics are widely used for medical device applications such as vascular and anterior cruciate ligament prostheses. Several years ago, we began functionalizing PET fabrics using anionic polymers to
Externí odkaz:
https://doaj.org/article/401fe1ef416446deac8e45f6db60fce0
Publikováno v:
Cells, Vol 11, Iss 23, p 3738 (2022)
Mesenchymal stromal cells (MSCs) represent a promising treatment for immune-related diseases due to their diverse immunomodulatory paracrine functions. However, progress of culture-expanded MSCs is hindered by inconsistent cell function, poor localiz
Externí odkaz:
https://doaj.org/article/818d1d4f5a4548eebaa9b2deb824f79b
Publikováno v:
Cells, Vol 11, Iss 18, p 2840 (2022)
A focal advantage of cell sheet technology has been as a scaffold-free three-dimensional (3D) cell delivery platform capable of sustained cell engraftment, survival, and reparative function. Recent evidence demonstrates that the intrinsic cell sheet
Externí odkaz:
https://doaj.org/article/d3ac5f494b9c458fbce1ddc15d9ae7cd
Autor:
Mitsuyoshi Nakao, Kyungsook Kim, Kenichi Nagase, David W. Grainger, Hideko Kanazawa, Teruo Okano
Publikováno v:
Stem Cell Research & Therapy, Vol 10, Iss 1, Pp 1-14 (2019)
Abstract Background In most stem cell therapy strategies reported to date, stem cells are introduced to damaged tissue sites to repair and regenerate the original tissue structure and function. MSC therapeutic efficacies are inconsistent, largely att
Externí odkaz:
https://doaj.org/article/52714e60c245451fa4b79109beff78b1
Assessment of a Siloxane Poly(urethane‐urea) Elastomer Designed for Implantable Heart Valve Leaflets
Autor:
Chris Jenney, Peter Millson, David W. Grainger, Robert Grubbs, Pathiraja Gunatillake, Simon J. McCarthy, James Runt, Jason Beith
Publikováno v:
Advanced NanoBiomed Research, Vol 1, Iss 2, Pp n/a-n/a (2021)
Synthetic polymer leaflets in prosthetic cardiac valves hold the potential to reduce calcification and thrombus, while improving blood flow, durability, and device economics. A recently developed siloxane poly(urethane‐urea) (LifePolymer, LP) exhib
Externí odkaz:
https://doaj.org/article/59d2f97d72614ce8b84aff7c5a42af2f