Zobrazeno 1 - 3
of 3
pro vyhledávání: '"David W. Freund"'
Autor:
David W. Freund, Mark Webster, Timothy A. Ayers, Timothy J. N. Watson, David L. Wenstrup, Stephen W. Horgan, Nik Shah, James P. Carey
Publikováno v:
Organic Process Research & Development. 7:521-532
A series of isoindoline analogues with either an indazole (HMR 2934, HMR 2651) or benzisoxazole (HMR 2543) appendage were prepared for the proposed treatment of psychiatric disorders such as obsessive compulsive disorder and attention deficit disorde
Autor:
Neal J. Fetner, Robert J. Cregge, Mark E. Webster, and Mark A. Nitz, Michael A. DesJardin, David W. Freund, David W. Burkhouse, Hoops John F, Richard E. Donaldson, Robert C. Clouse, Stephen W. Horgan, Gerald P. Heinrich, Daniel R. Henton, J. Russell McConnell, Robert T. Keaten, Christian T. Goralski, Kathy P. Barton, Michael E. LeTourneau, and Alexey Margolin, Sandra K. Stolz-Dunn
Publikováno v:
Organic Process Research & Development. 3:241-247
MDL 28,726 is a key intermediate in the synthesis of the ACE inhibitors MDL 27,210A and MDL 100,240. An efficient nine-step synthesis of this tricyclic acid, which has three chiral centers, was developed beginning with 3,4-dihydro-2H-pyran. A key ste
Autor:
Julie L. Geary, Melinda A. Correll, J. Chuck Poole, Xiao-Gao Liu, Larry D. Bratton, Fred E. Boyer, Thomas N. Thompson, Teng-Man Chen, Arun K. Mandagere, Bryan K. Jones, Kin-Kai Hwang, Mark E. Webster, Robert W. Knippenberg, Maynard George D, Stephen W. Horgan, Deborah E. Logan, Tieu-Binh Le, Kudlacz Elizabeth M, David L. Wenstrup, Burkholder Timothy P, Raymond S. Gross, David W. Freund
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 7:2531-2536
We recently described the synthesis and characterization of MDL 105,212, a non peptide tachykinin antagonist with high affinity for NK1 and NK2 receptors.1 Here we report the synthesis and structure-activity relationships for a series of analogs of M