Zobrazeno 1 - 10
of 37
pro vyhledávání: '"David W. Foley"'
Autor:
Ross Collins, Hyunah Lee, D. Heulyn Jones, Jonathan M. Elkins, Jason A. Gillespie, Carys Thomas, Alex G. Baldwin, Kimberley Jones, Loren Waters, Marie Paine, John R. Atack, Simon E. Ward, Olivera Grubisha, David W. Foley
Publikováno v:
Journal of Medicinal Chemistry. 65:13705-13713
LIM domain kinases 1 and 2 (LIMK1 and LIMK2) regulate actin dynamics and subsequently key cellular functions such as proliferation and migration. LIMK1 and LIMK2 phosphorylate and inactivate cofilin leading to increased actin polymerization. As a res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec61e46daab0767af551fe05809ccb38
https://doi.org/10.1021/acs.jmedchem.2c00751
https://doi.org/10.1021/acs.jmedchem.2c00751
Autor:
Atheer Zgair, Leonid Kagan, Jong Bong Lee, Hwi-yeol Yun, Peter Fischer, Min Gi Kim, Tae Hwan Kim, Pavel Gershkovich, Xiaowei Zang, Rui Gao, Ting Qian Ooi, David W. Foley, Hao Shao, Wan Tying Soh, Anthony J. Wilson, Gregory Voronin, Fadi Soukarieh
Publikováno v:
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 165
For treatment of chronic cancers, the oral administration route is preferred as it provides numerous advantages over other delivery routes. However, these benefits of oral chemotherapy can be limited due to unfavorable pharmacokinetics. Accordingly,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d06c6df5d069734a67bb06f9f93664c
https://pubmed.ncbi.nlm.nih.gov/33991611
https://pubmed.ncbi.nlm.nih.gov/33991611
Autor:
Chris Pepper, Frankie Lam, Hao Shao, David W. Foley, Peter Fischer, Tracey D. Bradshaw, Abdullahi Y. Abbas, Shiliang Huang, Shudong Wang, Pavel Gershkovich
Cyclin-dependent kinases (CDKs) are a family of Ser/Thr kinases involved in cell cycle and transcriptional regulation. CDK9 regulates transcriptional elongation and this unique property has made it a potential target for several diseases. Due to the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fa0033351dd727bdb5075ba87dd64aa
Autor:
David W. Foley, Steffan Willetts
Aspirin is a widely used medicine for a variety of indications. It is unique amongst non-steroidal anti-inflammatory drugs (NSAIDs) in that it causes irreversible acetylation of COX enzymes. Like all NSAIDs however, aspirin causes severe gastrointest
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fc1a7a489762bda8c74e87afb518b45
Publikováno v:
MedChemComm. 7:999-1002
The mammalian proton-coupled oligopeptide transporter PepT1 is recognised as an important route of oral drug delivery. Peptide-based compounds offer great potential as drugs but their application is limited by poor membrane permeability, amongst othe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5d68a392ce4caa577bf33bebc1c37f76
https://doi.org/10.1039/c5md00575b
https://doi.org/10.1039/c5md00575b
Autor:
Lesley-Anne Pearson, David W. Foley
Publikováno v:
ACS Medicinal Chemistry Letters. 8:143-144
The complexities of modern drug discovery-an interdisciplinary process that often takes years and costs billions-can be extremely challenging to explain to a public audience. We present details of a 30 minute demonstrative lecture that uses well-know
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87b996a9d6e97af6aba2afab7b7d8a16
https://doi.org/10.1021/acsmedchemlett.7b00015
https://doi.org/10.1021/acsmedchemlett.7b00015
Publikováno v:
Current Computer Aided-Drug Design. 6:68-78
In addition to being responsible for the majority of absorption of dietary nitrogen, the mammalian proton-coupled di- and tri-peptide transporter PepT1 is also recognised as a major route of drug delivery for several important classes of compound, in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a4ae639145729b5924bf4a07e306bd6
https://doi.org/10.2174/157340910790980133
https://doi.org/10.2174/157340910790980133
Autor:
Rachel Pettcrew, Myrtani Pieri, David W. Foley, E. J. Shepherd, David Meredith, Pat D. Bailey, Norma Lister, Philip A. Helliwell, George L. Kellett, Richard Boyd, Julie Affleck, Oliver J. Mace, John R. Bronk, Emma L. Morgan
Publikováno v:
The Journal of Physiology. 587:195-210
T1R taste receptors are present throughout the gastrointestinal tract. Glucose absorption comprises active absorption via SGLT1 and facilitated absorption via GLUT2 in the apical membrane. Trafficking of apical GLUT2 is rapidly up-regulated by glucos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5eadd0302f7a981d2afdd5bad46d9c75
https://doi.org/10.1113/jphysiol.2008.159616
https://doi.org/10.1113/jphysiol.2008.159616
Autor:
Xiangrui Jiang, Peter Fischer, Shiliang Huang, Shenhua Shi, Hao Shao, Frankie Lam, Shudong Wang, Xiangrui Liu, Nadiah Baharin, David W. Foley, Abdullah Y. Abbas
Publikováno v:
European journal of medicinal chemistry. 70
A series of 2,4,5-trisubstituted pyrimidines have been synthesised and characterised, which exhibited potent CDK inhibition and anti-proliferative activities. The structure–activity relationship is analysed and a rational for CDK9 selectivity is di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdfef124e2e13161fb49c3ba523ec15a
https://pubmed.ncbi.nlm.nih.gov/24185375
https://pubmed.ncbi.nlm.nih.gov/24185375
Autor:
Jane A. Endicott, Chris Pepper, Alison J. Hole, Abdullahi Y. Abbas, Shenhua Shi, Frankie Lam, Shudong Wang, Martin E.M. Noble, Sonja Baumli, Hao Shao, Xiangrui Liu, David W. Foley, Shiliang Huang, Peter Fischer
Publikováno v:
Journal of Medicinal Chemistry
Cancer cells often have a high demand for antiapoptotic proteins in order to resist programmed cell death. CDK9 inhibition selectively targets survival proteins and reinstates apoptosis in cancer cells. We designed a series of 4-thiazol-2- anilinopyr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10ca38616b46173ee2f7407ba2de20a5
https://pubmed.ncbi.nlm.nih.gov/23301767
https://pubmed.ncbi.nlm.nih.gov/23301767