Zobrazeno 1 - 10
of 43
pro vyhledávání: '"David W. E. Smith"'
Autor:
Darshan V. Desai, Hiromi Aoki-Ogata, W. Sean Fyvie, Hiroaki Mitsuya, Kenji Maeda, Joshua D. Kaufman, Harisha Garimella, Manabu Aoki, Ravikiran S. Yedidi, Arun K. Ghosh, Debananda Das, Simon B. Chang, David W. E. Smith, David A. Davis, Paul T. Wingfield
Publikováno v:
Antimicrobial Agents and Chemotherapy. 58:3679-3688
In the present study, GRL008, a novel nonpeptidic human immunodeficiency virus type 1 (HIV-1) protease inhibitor (PI), and darunavir (DRV), both of which contain a P2- bis -tetrahydrofuranyl urethane ( bis -THF) moiety, were found to exert potent ant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75005cba754684bc82d004fcd9a926a6
https://doi.org/10.1128/aac.00107-14
https://doi.org/10.1128/aac.00107-14
Autor:
David W. E. Smith
Publikováno v:
The Gerontologist. 37:200-207
This article is about the few humans who reach very old ages — here called “longevity outliers.” They are a distinct group, with lower mortality rates than most of the population. Centenarians are human longevity outliers. They are more resista
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bde333808b8161bcc4ef7d61670ed5e5
https://doi.org/10.1093/geront/37.2.200
https://doi.org/10.1093/geront/37.2.200
Autor:
David W. E. Smith
Publikováno v:
Cancer. 77:1367-1372
BACKGROUND Mortality rates of all malignant neoplastic diseases combined and of most individual kinds of cancer increase with age through most of the human life span. What happens to cancer mortality rates near the end of the life span has not been d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b862d0be1bca96f0e5ec67c05d4c8f12
https://doi.org/10.1002/(sici)1097-0142(19960401)77:7<1367::aid-cncr22>3.0.co
https://doi.org/10.1002/(sici)1097-0142(19960401)77:7<1367::aid-cncr22>3.0.co
Autor:
David W. E. Smith
Publikováno v:
OMEGA - Journal of Death and Dying. 31:143-150
The maximum human life span is presently recorded at about 120 years. Maximum life spans are inherited species characteristics and are consequences of evolution. The Human Genome Project will ultimately identify and characterize genes that are determ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ab19234bacb5510919134dbf2588ecca
https://doi.org/10.2190/jua5-4xk9-7ywv-cjum
https://doi.org/10.2190/jua5-4xk9-7ywv-cjum
Autor:
David W. E. Smith
Publikováno v:
Mechanisms of Ageing and Development. 81:51-60
Maximum life span is a characteristic of each species, and a diversity of maximum species life spans is seen in each mammalian order. It is argued here that different clusters of related long-lived species evolved independently. A variety of genes co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f4323d950a2a1015fe951e5f5a22a26
https://doi.org/10.1016/0047-6374(94)01581-6
https://doi.org/10.1016/0047-6374(94)01581-6
Autor:
David W. E. Smith
Publikováno v:
BioEssays. 16:907-911
This article focuses on the occasional individuals of many species that live longer than is usual for their populations – here called longevity outliers. They appear to be exceptions to the usual patterns of mortality rates that increase with age.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c2c23e2c03d079c947facf3fd88be2a
https://doi.org/10.1002/bies.950161209
https://doi.org/10.1002/bies.950161209
Autor:
David W. E. Smith
Publikováno v:
Gerontology. 44(6)
Background: Causes of death have changed greatly in the United States during the 20th century. Objective: To detail these changes in elderly people during 1950–1990. Methods: The source of data was ‘Vital Statistics of the United States’ for th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e287b982545e1ca604a8264425d52634
https://pubmed.ncbi.nlm.nih.gov/9813432
https://pubmed.ncbi.nlm.nih.gov/9813432
Autor:
David W. E. Smith
Publikováno v:
Journal of geriatric psychiatry and neurology. 11(1)
The nosology of dementing conditions of very old people, as described in the International Classification of Diseases, Ninth Revision (ICD-9) and reported in Vital Statistics of the United States, is examined. Methods included a questionnaire of stat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b04ddbe7156e62c96fa1cb66d8e39ee
https://pubmed.ncbi.nlm.nih.gov/9686749
https://pubmed.ncbi.nlm.nih.gov/9686749
Autor:
David W. E. Smith
Publikováno v:
Biotechnology progress. 12(4)
tRNA can have large effects on the expression and overexpression of heterologous genes in microbial expression systems through reduced translation and errors in amino acid sequences of protein products. Examples are given of large effects on gene exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d57ab8b14a61e2594ed9ef8ed5b7e97a
https://pubmed.ncbi.nlm.nih.gov/8987471
https://pubmed.ncbi.nlm.nih.gov/8987471
Autor:
Mary E. Ulmer, F. Wilson Jackson, David W. E. Smith, Jane Straker, Jennifer Snell, Alison W. Brett
Publikováno v:
International journal of aginghuman development. 39(3)
This survey study focuses on stairs in the homes of a substantial number of independently living elderly (60+) residents of a community in which there are mostly multistory houses and apartment buildings with stairs. While the majority could climb th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da9f935350f3ff6eb91db9e3dc6cc523
https://pubmed.ncbi.nlm.nih.gov/7875916
https://pubmed.ncbi.nlm.nih.gov/7875916