Zobrazeno 1 - 10 of 21 pro vyhledávání: '"David W. Draper"'
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Abstract 2749: Preclinical assessment of chimeric antigen receptor (CAR) T persistence and functionality in the disseminated NALM6-Luc human B cell acute lymphoblastic leukemia (ALL) model
Autor: David W. Draper, Derrik Germain, Stacey Roys, Olivia Nelson, Scott Wise
Publikováno v: Cancer Research. 83:2749-2749
Preclinical in vivo models are used to profile or refine CAR T therapies before advancing to human studies. Establishing long-term CAR T persistence and efficacy continues to challenge progress in the CAR T space, thus development of robust platforms
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f1243ca06a9abf0eb10ac2eae9ced346
https://doi.org/10.1158/1538-7445.am2023-2749
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Leucine-rich repeats and calponin homology containing 4 (Lrch4) regulates the innate immune response
Autor: Wan Chi Lin, Michael B. Fessler, Jim J. Aloor, Kathleen M. Azzam, Kristin A. Gabor, Jennifer H. Madenspacher, Artiom Gruzdev, Julie M. Lowe, David W. Draper, B. Alex Merrick, Kymberly M. Gowdy, Geoffrey A. Mueller, John Guardiola, Michael W. Henderson
Publikováno v: Journal of Biological Chemistry. 294:1997-2008
Toll-like receptors (TLRs) are pathogen-recognition receptors that trigger the innate immune response. Recent reports have identified accessory proteins that provide essential support to TLR function through ligand delivery and receptor trafficking.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8f3e066ae4b4c1e24a499a6cfb18983
https://doi.org/10.1074/jbc.ra118.004300
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Abstract 1633: Comprehensive cell- and gene-based tumor profiling using flow cytometry and Nanostring in a murine bladder cancer model
Autor: Philip E. Lapinski, David W. Draper, Scott Wise
Publikováno v: Cancer Research. 82:1633-1633
Background: Five checkpoint immunotherapies that target the PD-1/PD-L1 axis are currently FDA approved. Novel approaches are helping to identify new combination treatment strategies for therapeutic intervention of bladder cancer, which is the thirtee
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::da08b71c7cfd0ddd9222eeee06d62fe3
https://doi.org/10.1158/1538-7445.am2022-1633
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Abstract 5537: Anti-PD-1 reduces the immuno-suppressive phenotype of myeloid subsets in the murine Hepa 1-6 tumor
Autor: Maryland Franklin, Philip Lapinski, Brogan Yarzabek, Scott C. Wise, Hillary Evens, David W. Draper
Publikováno v: Cancer Research. 80:5537-5537
Hepatocellular carcinoma (HCC) is the third leading cause of cancer related deaths and is refractory to standard chemo and radiation therapies. Clinical trials are tackling unresectable HCC through combination approaches using immunotherapies and hav
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d70c9c1201c65f1930fe1e001b96482f
https://doi.org/10.1158/1538-7445.am2020-5537
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7
The Undiagnosed Diseases Program Integrated Collaboration System (UDPICS): One Program’s Experience Developing Custom Software to Support Research for Complex-Disease Families
Autor: Zaheer M. Valivullah, David W. Draper, Guoyun Yu, Jessica Guzman, William A. Gahl, Murat Sincan, Elizabeth M. J. Lee, David R. Adams
Publikováno v: Children, Vol 2, Iss 3, Pp 342-357 (2015)
Children
The Undiagnosed Diseases Program (UDP) was started in 2008 with the goals of making diagnoses and facilitating related translational research. The individuals and families seen by the UDP are often unique and medically complex. Approximately 40% of U
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93ad3072b98b996ee940460bd6dea3fd
http://www.mdpi.com/2227-9067/2/3/342
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Terrestrial and space-based RFI observed by the GPM microwave imager (GMI) within NTIA semi-protected passive earth exploration bands at 10.65 and 18.7 GHz
Autor: David W. Draper
Publikováno v: 2016 Radio Frequency Interference (RFI).
The Global Precipitation Measurement (GPM) Microwave Imager provides a valuable case study to evaluate levels and distribution of observable radio frequency interference (RFI) in semi-protected bands above 10 GHz from terrestrial and space-based sour
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a21a84a7f8ca2e3d20535f499c4f89c8
https://doi.org/10.1109/rfint.2016.7833526
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ATP Binding Cassette Transporter G1 Deletion Induces IL-17–Dependent Dysregulation of Pulmonary Adaptive Immunity
Autor: Jennifer H. Madenspacher, Michael B. Fessler, Donald N. Cook, Hideki Nakano, David W. Draper, Rhonda H. Wilson, Arun R. Pandiri, Kymberly M. Gowdy, Julie F. Foley, Alan T. Remaley, Gregory S. Whitehead
Publikováno v: The Journal of Immunology. 188:5327-5336
Mice with genetic deletion of the cholesterol transporter ATP binding cassette G1 (ABCG1) have pulmonary lipidosis and enhanced innate immune responses in the airway. Whether ABCG1 regulates adaptive immune responses to the environment is unknown. To
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::750929971fc69598120761349a3ba5ba
https://doi.org/10.4049/jimmunol.1101605
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10
Planet Signal Extraction for theTerrestrial Planet FinderInterferometer
Autor: Brent Ware, David W. Draper, Oliver P. Lay, Philip Dumont, M. Charles Noecker, N. M. Elias
Publikováno v: The Astronomical Journal. 131:1822-1836
Signal extraction is a vital link between science and systems-engineering requirements. In this paper we present a Terrestrial Planet Finder (TPF) interferometer planet-signal-extraction algorithm and demonstrate the performance of several nulling-in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3b4945cab0e48d6a2d838ce8f57039ea
https://doi.org/10.1086/499528
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