Zobrazeno 1 - 10
of 10
pro vyhledávání: '"David W. Dales"'
Autor:
Jason L. Townson, Ann F. Chambers, Paula J. Foster, Ian C. MacDonald, Michael B. Sporn, David W. Dales, Benjamin D. Hedley, Karen T. Liby, Lisa Mackenzie
Publikováno v:
Clinical & Experimental Metastasis. 28:309-317
Survival following diagnosis of liver metastasis remains poor and improved treatment strategies to combat liver metastases are needed. Synthetic triterpenoids, including 1-[2-cyano-3-,12-dioxooleana-1,9(11)-dien-28-oyl]imidazole (CDDO-Imidazolide or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86e0e3733ed586b7bb2c299a46f59f9d
https://doi.org/10.1007/s10585-011-9374-z
https://doi.org/10.1007/s10585-011-9374-z
Autor:
Kedar S. Vaidya, Ian C. MacDonald, Carl O. Postenka, Benjamin D. Hedley, Ann F. Chambers, David W. Dales, Pushar Phadke, Lisa Mackenzie
Publikováno v:
Clinical & Experimental Metastasis. 25:727-740
The majority of breast cancer related deaths occur as a result of metastasis. The failure of effective treatments for metastasis is the underlying cause for this. Much remains unknown about the process of metastasis and how best to prevent or treat m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab53eea6356d984f021fca61e5438656
https://doi.org/10.1007/s10585-008-9184-0
https://doi.org/10.1007/s10585-008-9184-0
Autor:
Ann F. Chambers, Hon S. Leong, Amy E. Robertson, Connor D. MacMillan, John D. Lewis, Alan B. Tuck, David W. Dales
Publikováno v:
Scientific Reports
Planar cell polarity (PCP) signaling has been shown in different studies to either promote or inhibit the malignancy of breast cancer. Using the 21T cell lines, which were derived from an individual patient and represent distinct stages of progressio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b684854e1777c4f7eade9b771df1dce1
http://europepmc.org/articles/PMC4303872
http://europepmc.org/articles/PMC4303872
Autor:
Yves A. Muller, David W. Dales, George V. Avvakumov, Geoffrey L. Hammond, Gisela Sklenar, Irina Grishkovskaya
Publikováno v:
The EMBO Journal. 19:504-512
Human sex hormone-binding globulin (SHBG) transports sex steroids in blood and regulates their access to target tissues. In biological fluids, SHBG exists as a homodimer and each monomer comprises two laminin G-like domains (G domains). The crystal s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b55b0d4a5241e0b341bde3b5774d3e1e
https://doi.org/10.1093/emboj/19.4.504
https://doi.org/10.1093/emboj/19.4.504
Publikováno v:
Biochemistry. 34:3231-3238
To determine the minimal sequence requirements for steroid binding and dimerization of human sex hormone-binding globulin (SHBG), the SHBG polypeptide and various SHBG deletion mutants were expressed as glutathione S-transferase (GST) fusion proteins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41abd98bb6531364e00531ab0ead47cf
https://doi.org/10.1021/bi00010a012
https://doi.org/10.1021/bi00010a012
Publikováno v:
Endocrinology. 131:2120-2126
Glucocorticoids promote the development of many organ systems vital for extrauterine survival, and fetal cortisol provides the trigger for birth in sheep. The activity of glucocorticoids may be influenced at a cellular level by 11 beta-hydroxysteroid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de843c253bbbcc585779c10dba8b0bb6
https://doi.org/10.1210/endo.131.5.1425412
https://doi.org/10.1210/endo.131.5.1425412
Autor:
Benjamin D, Hedley, Danny R, Welch, Alison L, Allan, Waleed, Al-Katib, David W, Dales, Carl O, Postenka, Graham, Casey, Ian C, Macdonald, Ann F, Chambers
Publikováno v:
International journal of cancer. 123(3)
Breast cancer metastasis suppressor 1 (BRMS1) inhibits the ability of multiple human and murine cancer cell lines to metastasize to lymph nodes, bones and lungs. Comparison of mRNA expression in metastatic MDA-MB-435 human carcinoma cells (435) and m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5621a81bf7c2449d7c3f8432dc36be96
https://pubmed.ncbi.nlm.nih.gov/18470911
https://pubmed.ncbi.nlm.nih.gov/18470911
Autor:
David W. Dales, Carl O. Postenka, Ann F. Chambers, Allen G. Clifford, Milica Krstic, Siddika Pardhan, Alan B. Tuck, Connor D. MacMillan, Hon S. Leong
Publikováno v:
Cancer Research. 74:4055-4055
The transcriptional regulator TBX3 has been shown to be elevated in metastatic breast cancer and is thought to be involved in promoting malignancy of breast and other carcinomas. In a series of cell lines derived from the same patient with breast can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e375ff5c033fac18e6745d1fab300d6
https://doi.org/10.1158/1538-7445.am2014-4055
https://doi.org/10.1158/1538-7445.am2014-4055
Autor:
Geoffrey L. Hammond, Gisela Sklenar, Joachim Behlke, Yves A. Muller, David W. Dales, Irina Grishkovskaya, George V. Avvakumov
Publikováno v:
Acta crystallographica. Section D, Biological crystallography. 55(Pt 12)
The amino-teminal laminin G-like domain of human sex hormone-binding globulin (SHBG), which contains the steroid-binding site and the dimerization domain, has been produced in Escherichia coli, purified to homogeneity and crystallized in complex with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0322001d23fed02459e60e50ea5704a
https://pubmed.ncbi.nlm.nih.gov/10666590
https://pubmed.ncbi.nlm.nih.gov/10666590
Autor:
Ann F. Chambers, Milica Krstic, Allen G. Clifford, Alan B. Tuck, David W. Dales, Hon S. Leong, Connor D. MacMillan, Lesley H. Souter, Carl O. Postenka
Publikováno v:
BMC Cancer
Background TBX3 is a T-box transcription factor repressor that is elevated in metastatic breast cancer and is believed to promote malignancy of tumor cells, possibly by promoting cell survival and epithelial-mesenchymal transition. Methods The relati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c626328c0efee71c398fbb21f20e951