Zobrazeno 1 - 10
of 23
pro vyhledávání: '"David W. Brankow"'
Autor:
Brian Mingtung Chan, Kelly A Berry, David W. Brankow, Chadwick T. King, Sylvia Nai-Yu Hu, Nebojsa Kezunovic, Tom Boone, Licheng Shi, Cen Xu, Colin V. Gegg, Matt R. Kelley, Hsieng Sen Lu
Publikováno v:
ACS Pharmacol Transl Sci
[Image: see text] In 2018, the United States Food and Drug Administration (FDA) approved Aimovig (erenumab) for the prevention of migraine. Erenumab is the first FDA approved antibody therapeutic against a G-protein-coupled receptor, the canonical re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0a97f4f56650c1bbf83553db82caa76
https://doi.org/10.1021/acsptsci.9b00061
https://doi.org/10.1021/acsptsci.9b00061
Autor:
David W. Brankow, Harvey R. Herschman
Publikováno v:
Genes and Signal Transduction in Multistage Carcinogenesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f89d6422fbb8cb7afb54bc12b5576d2b
https://doi.org/10.1201/9781003066101-5
https://doi.org/10.1201/9781003066101-5
Autor:
David W. Brankow, Shu-Chen Lu, Jing Xu, Shuying Liu, Shirley Steavenson, Colin V. Gegg, Richard A. Lindberg, Wei Gu, Narumol Chinookoswong, Murielle M. Véniant
Publikováno v:
Molecular Pharmacology. 75:901-907
Ghrelin is a 28-amino acid peptide secreted mainly by the stomach. Acyl-ghrelin, which binds to and activates the growth hormone secretagogue receptor type 1a (GHS-R1a), is considered to be the active form for its orexigenic effects. It has been demo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::295b85dcb2ee6b40eaa2abba9ecd4f50
https://doi.org/10.1124/mol.108.052852
https://doi.org/10.1124/mol.108.052852
Autor:
David W. Brankow, Andrew F. Knudten, Osslund Timothy D, James R. Grant, Tony Lorenzini, Gary Rogers, David Chang, Lynette Buck, Sheilah Asher, Ken Aoki, Steve Elliott, Geri Trail, Rachell Navarro, Joan C. Egrie, Sylvia Hu, Natasha Hernday, Janis Fuller, Renee Komorowski, Leigh Busse, Frank Martin, Nancy Levin, Norma Rogers, Martha Hokum
Publikováno v:
Nature Biotechnology. 21:414-421
Delivery of protein therapeutics often requires frequent injections because of low activity or rapid clearance, thereby placing a burden on patients and caregivers. Using glycoengineering, we have increased and prolonged the activity of proteins, thu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9b2a4147feba2c1f5828f1b58717c5d
https://doi.org/10.1038/nbt799
https://doi.org/10.1038/nbt799
Autor:
Frank Martin, C. Q. Chen, Jeffrey Lewis, Songmei Yin, Raffaella Faggioni, David C. Hill, Russell C. Cattley, Meiying Qi, Harvey Yamane, Heather Brown, Sheila Scully, Silvia Flores, Jane Guo, Tina Meng, Claudia Baikalov, David W. Brankow, Sylvia Hu, Tom Boone, Giorgio Senaldi
Publikováno v:
The Journal of Immunology. 167:5913-5920
IL-18-binding protein (IL-18BP) is a natural IL-18 inhibitor. Human IL-18BP isoform a was produced as fusion construct with human IgG1 Fc and assessed for binding and neutralizing IL-18. IL-18BP-Fc binds human, mouse, and rat IL-18 with high affinity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00b9cdc7efd9d252e13ba8e6d85f8ed3
https://doi.org/10.4049/jimmunol.167.10.5913
https://doi.org/10.4049/jimmunol.167.10.5913
Autor:
Michael G. Sonnenberg, Kent Miner, Ariela Hui, Raffi Manoukian, John M. Delaney, Ming Zhang, Marco A. Coccia, Hong Han, Tom Horan, John Whoriskey, Jeanne Pistillo, Steven Kiyoshi Yoshinaga, Sanjay D. Khare, Tianang Dai, Tom Boone, David W. Brankow, Tadahiko Kohno
Publikováno v:
International Immunology. 12:1439-1447
Optimal T cell activation requires the interactions of co-stimulatory molecules, such as those in the CD28 and B7 protein families. Recently, we described the co-stimulatory properties of the murine ligand to ICOS, which we designated as B7RP-1. Here
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::862e5ff3cec520f50fd1e247ea32e879
https://doi.org/10.1093/intimm/12.10.1439
https://doi.org/10.1093/intimm/12.10.1439
Autor:
Gary Elliott, Grace Shih, Ming Zhang, Gwyneth Van, Pauline Campbell, Christine L. Shaklee, Tak W. Mak, John Whoriskey, Ulla Sarmiento, Jane Guo, Tadahiko Kohno, David Chang, Ariela Hui, Marco A. Coccia, Tom Horan, Tianang Dai, Anna Tafuri-Bladt, Laura Chiu, Giorgio Senaldi, Sheila Scully, David W. Brankow, Susan McCabe, Gordon S. Duncan, Steven Kiyoshi Yoshinaga, Sanjay D. Khare, Arda Shahinian
Publikováno v:
Nature. 402:827-832
T-cell activation requires co-stimulation through receptors such as CD28 and antigen-specific signalling through the T-cell antigen receptor. Here we describe a new murine costimulatory receptor-ligand pair. The receptor, which is related to CD28 and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ff4f55ca403f245339d6b589e29d12e
https://doi.org/10.1038/45582
https://doi.org/10.1038/45582
Autor:
Yueh-Rong Hsu, Morris Charles F, Viswanatham Katta, Sylvia Hu, Julia Tseng, David W. Brankow, Hsu Eric W, Hsieng Sen Lu, William C. Kenney
Publikováno v:
Protein Expression and Purification. 12:189-200
Keratinocyte growth factor (KGF) is a member of the fibroblast growth factor family that acts specifically on epithelial cells in a paracrine mode. We employed a mammalian expression system to synthesize recombinant human KGF and isolated two prepara
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::432f8d7d577f2ebb836736a48895afbf
https://doi.org/10.1006/prep.1997.0840
https://doi.org/10.1006/prep.1997.0840
Autor:
David Chang, Margery Nicolson, John S. Philo, Sylvia Hu, Barry J. Ratzkin, David W. Brankow, Tsutomu Arakawa, Robert E. Pacifici, Duanzhi Wen, Yoshiko Kita, Julia Tseng, Jie Wen, Yi Luo, Tom Horan
Publikováno v:
Biochemical and Biophysical Research Communications. 226:59-69
A panel of mAbs were generated against the purified soluble form of erbB2/Her2 receptor, corresponding to the extracellular region of the receptor, and examined for their ability to mimic the receptor ligand. Some of the mAbs strongly induced tyrosin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a15b3bf4f5f5e1472c7f8ee8a72efd23
https://doi.org/10.1006/bbrc.1996.1311
https://doi.org/10.1006/bbrc.1996.1311
Publikováno v:
Journal of Biological Chemistry. 270:19188-19196
neu differentiation factor (NDF), also known as heregulin, is structurally related to the epidermal growth factor family of growth factors; it stimulates tyrosine phosphorylation of the neu/HER-2 oncogene and causes differentiation of certain human b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::98eacffd054ceff3a403e7ad82073d96
https://doi.org/10.1074/jbc.270.32.19188
https://doi.org/10.1074/jbc.270.32.19188