Zobrazeno 1 - 10
of 290
pro vyhledávání: '"David W Threadgill"'
Autor:
Dan Li, Chenhan Zhong, Mengyuan Yang, Li He, Hang Chang, Ning Zhu, Susan E Celniker, David W Threadgill, Antoine M Snijders, Jian-Hua Mao, Ying Yuan
Publikováno v:
Gut Microbes, Vol 16, Iss 1 (2024)
ABSTRACTThe insights into interactions between host genetics and gut microbiome (GM) in colorectal tumor susceptibility (CTS) remains lacking. We used Collaborative Cross mouse population model to identify genetic and microbial determinants of Azoxym
Externí odkaz:
https://doaj.org/article/227e8b75c1d146fb911a9277a62d6dff
Autor:
Phillip Wulfridge, Adam Davidovich, Anna C Salvador, Gabrielle C Manno, Rakel Tryggvadottir, Adrian Idrizi, M Nazmul Huda, Brian J Bennett, L Garry Adams, Kasper D Hansen, David W Threadgill, Andrew P Feinberg
Publikováno v:
PLoS Genetics, Vol 19, Iss 10, p e1010997 (2023)
Diet-related metabolic syndrome is the largest contributor to adverse health in the United States. However, the study of gene-environment interactions and their epigenomic and transcriptomic integration is complicated by the lack of environmental and
Externí odkaz:
https://doaj.org/article/604db79494c6422c98dfaaf4680a4193
Autor:
Kristin Scoggin, Rachel Lynch, Jyotsana Gupta, Aravindh Nagarajan, Maxwell Sheffield, Ahmed Elsaadi, Christopher Bowden, Manuchehr Aminian, Amy Peterson, L Garry Adams, Michael Kirby, David W Threadgill, Helene L Andrews-Polymenis
Publikováno v:
PLoS Genetics, Vol 18, Iss 4, p e1010075 (2022)
Salmonella infections typically cause self-limiting gastroenteritis, but in some individuals these bacteria can spread systemically and cause disseminated disease. Salmonella Typhimurium (STm), which causes severe systemic disease in most inbred mice
Externí odkaz:
https://doaj.org/article/04e6a9cf6fea4f91be13e3d094ea8fbc
Publikováno v:
PLoS Genetics, Vol 17, Iss 11, p e1009931 (2021)
ERBB3 has gained attention as a potential therapeutic target to treat colorectal and other types of cancers. To confirm a previous study showing intestinal polyps are dependent upon ERBB3, we generated an intestinal epithelia-specific ERBB3 deletion
Externí odkaz:
https://doaj.org/article/bd73c639044d469990151c1c47603ca0
Autor:
Koedi S Lawley, Raquel R Rech, Faith Elenwa, Gang Han, Aracely A Perez Gomez, Katia Amstalden, C Jane Welsh, Colin R Young, David W Threadgill, Candice L Brinkmeyer-Langford
Publikováno v:
PLoS ONE, Vol 16, Iss 8, p e0256370 (2021)
Host genetic background is a significant driver of the variability in neurological responses to viral infection. Here, we leverage the genetically diverse Collaborative Cross (CC) mouse resource to better understand how chronic infection by Theiler's
Externí odkaz:
https://doaj.org/article/07223f1805384c1fae1ab5708c93dae4
Autor:
Lisa E Gralinski, Martin T Ferris, David L Aylor, Alan C Whitmore, Richard Green, Matthew B Frieman, Damon Deming, Vineet D Menachery, Darla R Miller, Ryan J Buus, Timothy A Bell, Gary A Churchill, David W Threadgill, Michael G Katze, Leonard McMillan, William Valdar, Mark T Heise, Fernando Pardo-Manuel de Villena, Ralph S Baric
Publikováno v:
PLoS Genetics, Vol 11, Iss 10, p e1005504 (2015)
New systems genetics approaches are needed to rapidly identify host genes and genetic networks that regulate complex disease outcomes. Using genetically diverse animals from incipient lines of the Collaborative Cross mouse panel, we demonstrate a gre
Externí odkaz:
https://doaj.org/article/b8f7d6c3b6f74bfd8dd8a1fd634eea07
Autor:
John P Didion, Andrew P Morgan, Amelia M-F Clayshulte, Rachel C Mcmullan, Liran Yadgary, Petko M Petkov, Timothy A Bell, Daniel M Gatti, James J Crowley, Kunjie Hua, David L Aylor, Ling Bai, Mark Calaway, Elissa J Chesler, John E French, Thomas R Geiger, Terry J Gooch, Theodore Garland, Alison H Harrill, Kent Hunter, Leonard McMillan, Matt Holt, Darla R Miller, Deborah A O'Brien, Kenneth Paigen, Wenqi Pan, Lucy B Rowe, Ginger D Shaw, Petr Simecek, Patrick F Sullivan, Karen L Svenson, George M Weinstock, David W Threadgill, Daniel Pomp, Gary A Churchill, Fernando Pardo-Manuel de Villena
Publikováno v:
PLoS Genetics, Vol 11, Iss 2, p e1004850 (2015)
Significant departures from expected Mendelian inheritance ratios (transmission ratio distortion, TRD) are frequently observed in both experimental crosses and natural populations. TRD on mouse Chromosome (Chr) 2 has been reported in multiple experim
Externí odkaz:
https://doaj.org/article/53c2f98bb98349e2a1907e6090291e44
Autor:
Michael J Large, Margeaux Wetendorf, Rainer B Lanz, Sean M Hartig, Chad J Creighton, Michael A Mancini, Ertug Kovanci, Kuo-Fen Lee, David W Threadgill, John P Lydon, Jae-Wook Jeong, Francesco J DeMayo
Publikováno v:
PLoS Genetics, Vol 10, Iss 6, p e1004451 (2014)
Infertility and adverse gynecological outcomes such as preeclampsia and miscarriage represent significant female reproductive health concerns. The spatiotemporal expression of growth factors indicates that they play an important role in pregnancy. Th
Externí odkaz:
https://doaj.org/article/aa482490e83040538b59855dac1867be
Autor:
Martin T Ferris, David L Aylor, Daniel Bottomly, Alan C Whitmore, Lauri D Aicher, Timothy A Bell, Birgit Bradel-Tretheway, Janine T Bryan, Ryan J Buus, Lisa E Gralinski, Bart L Haagmans, Leonard McMillan, Darla R Miller, Elizabeth Rosenzweig, William Valdar, Jeremy Wang, Gary A Churchill, David W Threadgill, Shannon K McWeeney, Michael G Katze, Fernando Pardo-Manuel de Villena, Ralph S Baric, Mark T Heise
Publikováno v:
PLoS Pathogens, Vol 9, Iss 2, p e1003196 (2013)
Genetic variation contributes to host responses and outcomes following infection by influenza A virus or other viral infections. Yet narrow windows of disease symptoms and confounding environmental factors have made it difficult to identify polymorph
Externí odkaz:
https://doaj.org/article/7b65541d5dda41df84e78d9a797b012a
Autor:
Erica S Rinella, David W Threadgill
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e39552 (2012)
Molecule-targeted therapies are being widely developed and deployed, but they are frequently less effective in clinical trials than predicted based upon preclinical studies. Frequently, only a single model or genetic background is utilized using diet
Externí odkaz:
https://doaj.org/article/66c259a327334307a349494e2fea30b7