Zobrazeno 1 - 10
of 200
pro vyhledávání: '"David W Taylor"'
Autor:
Caitlyn L McCafferty, Ophelia Papoulas, Mareike A Jordan, Gabriel Hoogerbrugge, Candice Nichols, Gaia Pigino, David W Taylor, John B Wallingford, Edward M Marcotte
Publikováno v:
eLife, Vol 11 (2022)
Intraflagellar transport (IFT) is a conserved process of cargo transport in cilia that is essential for development and homeostasis in organisms ranging from algae to vertebrates. In humans, variants in genes encoding subunits of the cargo-adapting I
Externí odkaz:
https://doaj.org/article/5936f1f2344a45909019f9e1c8895338
Publikováno v:
PLoS ONE, Vol 16, Iss 5, p e0245710 (2021)
Buchnera aphidicola is an intracellular bacterial symbiont of aphids and maintains a small genome of only 600 kbps. Buchnera is thought to maintain only genes relevant to the symbiosis with its aphid host. Curiously, the Buchnera genome contains gene
Externí odkaz:
https://doaj.org/article/35a979f942594a0884c0b3b794720358
Autor:
Samuel Wanji, Jonas A Kengne-Ouafo, Mathias E Esum, Patrick W N Chounna, Nicholas Tendongfor, Bridget F Adzemye, Joan E E Eyong, Isaac Jato, Fabrice R Datchoua-Poutcheu, Elvis Kah, Peter Enyong, David W Taylor
Publikováno v:
Parasites & Vectors, Vol 8, Iss 1, Pp 1-21 (2015)
Abstract Background Community-Directed Treatment with Ivermectin (CDTI) is the main strategy adopted by the African Programme for Onchocerciasis control (APOC). Recent reports from onchocerciasis endemic areas of savannah zones have demonstrated the
Externí odkaz:
https://doaj.org/article/ac8d8c57518a471ca0c3a94ea1665aa6
Autor:
Juan F Quintana, Benjamin L Makepeace, Simon A Babayan, Alasdair Ivens, Kenneth M Pfarr, Mark Blaxter, Alexander Debrah, Samuel Wanji, Henrietta F Ngangyung, Germanus S Bah, Vincent N Tanya, David W Taylor, Achim Hoerauf, Amy H Buck
Publikováno v:
Parasites & Vectors, Vol 8, Iss 1, Pp 1-11 (2015)
Abstract Background microRNAs (miRNAs), a class of short, non-coding RNA can be found in a highly stable, cell-free form in mammalian body fluids. Specific miRNAs are secreted by parasitic nematodes in exosomes and have been detected in the serum of
Externí odkaz:
https://doaj.org/article/08ed4d70b09c41eb8d59beed49477bed
Autor:
Peter J Hotez, Maria Elena Bottazzi, Bin Zhan, Benjamin L Makepeace, Thomas R Klei, David Abraham, David W Taylor, Sara Lustigman
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 9, Iss 1, p e0003422 (2015)
Externí odkaz:
https://doaj.org/article/f363a2a6d8e04595a0d2fb3b55265ebc
Autor:
Gnatoulma Katawa, Laura E Layland, Alex Y Debrah, Charlotte von Horn, Linda Batsa, Alexander Kwarteng, Sandra Arriens, David W Taylor, Sabine Specht, Achim Hoerauf, Tomabu Adjobimey
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 9, Iss 1, p e3414 (2015)
Clinical manifestations in onchocerciasis range from generalized onchocerciasis (GEO) to the rare but severe hyperreactive (HO)/sowda form. Since disease pathogenesis is associated with host inflammatory reactions, we investigated whether Th17 respon
Externí odkaz:
https://doaj.org/article/f2da924f6cba47eaa0e98b3bbc948e8c
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 9, Iss 7, p e0003938 (2015)
BACKGROUND:Currently, the predominant onchocerciasis control strategy in Africa is annual mass drug administration (MDA) with ivermectin. However, there is a consensus among the global health community, supported by mathematical modelling, that oncho
Externí odkaz:
https://doaj.org/article/8e6ab60362744b9890d9be1fa8549819
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 6, Iss 12, p e1968 (2012)
Filarial nematodes are tissue-dwelling parasites that can be killed by Th2-driven immune effectors, but that have evolved to withstand immune attack and establish chronic infections by suppressing host immunity. As a consequence, the efficacy of a va
Externí odkaz:
https://doaj.org/article/63e6b2a7c6044c978a2aca9520f41fda
Autor:
Judith E Allen, Ohene Adjei, Odile Bain, Achim Hoerauf, Wolfgang H Hoffmann, Benjamin L Makepeace, Hartwig Schulz-Key, Vincent N Tanya, Alexander J Trees, Samuel Wanji, David W Taylor
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 2, Iss 4, p e217 (2008)
River blindness is a seriously debilitating disease caused by the filarial parasite Onchocerca volvulus, which infects millions in Africa as well as in South and Central America. Research has been hampered by a lack of good animal models, as the para
Externí odkaz:
https://doaj.org/article/9d1f33605a1b4e62a09a3c957b063a9e
Autor:
Evan A. Schwartz, Tess M. McBride, Jack P. K. Bravo, Daniel Wrapp, Peter C. Fineran, Robert D. Fagerlund, David W. Taylor
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
I-D CRISPR-Cascade can target both single-stranded and double-stranded nucleic acids. Here, Schwartz et. al determine these structures and reveal large-scale rearrangements that allow for target discrimination and destruction.
Externí odkaz:
https://doaj.org/article/c6f9cd3cd7a84706b774e67908f2b1ed