Zobrazeno 1 - 10
of 139
pro vyhledávání: '"David W Stepp"'
Autor:
Yusi Wang, Paramita Pati, Yiming Xu, Feng Chen, David W Stepp, Yuqing Huo, R Daniel Rudic, David J R Fulton
Publikováno v:
PLoS ONE, Vol 11, Iss 5, p e0155075 (2016)
The circadian clock is a transcriptional network that functions to regulate the expression of genes important in the anticipation of changes in cellular and organ function. Recent studies have revealed that the recognition of pathogens and subsequent
Externí odkaz:
https://doaj.org/article/ce1dc2f6007a48d3841efab58d865b10
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e100102 (2014)
Nox5 is an EF-hand containing, calcium-dependent isoform of the NADPH oxidase family of reactive oxygen species (ROS) generating enzymes. Altered expression and activity of Nox5 has been reported in cardiovascular diseases and cancers but the absence
Externí odkaz:
https://doaj.org/article/a2b1c34bf21443b99b1657ad5396b4b8
Autor:
Feng Chen, Yanfang Yu, Steven Haigh, John Johnson, Rudolf Lucas, David W Stepp, David J R Fulton
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e88405 (2014)
NADPH oxidase5 (Nox5) is a novel Nox isoform which has recently been recognized as having important roles in the pathogenesis of coronary artery disease, acute myocardial infarction, fetal ventricular septal defect and cancer. The activity of Nox5 an
Externí odkaz:
https://doaj.org/article/61af9c061e8448f786d8e5de31bdb73e
Autor:
Ciprian B Anea, Maoxiang Zhang, Feng Chen, M Irfan Ali, C Michael M Hart, David W Stepp, Yevgeniy O Kovalenkov, Ana-Maria Merloiu, Paramita Pati, David Fulton, R Daniel Rudic
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e78626 (2013)
Recent studies have shown that circadian clock disruption is associated with pathological remodeling in the arterial structure and vascular stiffness. Moreover, chronic circadian disruption is associated with dysfunction in endothelial responses and
Externí odkaz:
https://doaj.org/article/9b8c7cdd1aa542c29a788daedc32bc7f
Autor:
Stephen Haigh, Zach L. Brown, Mitch A. Shivers, Hunter G. Sellers, Madison A. West, Scott A. Barman, David W. Stepp, Gabor Csanyi, David J. R. Fulton
Publikováno v:
Antioxidants, Vol 12, Iss 9, p 1689 (2023)
The detection of superoxide anion (O2●−) in biological tissues remains challenging. Barriers to convenient and reproducible measurements include expensive equipment, custom probes, and the need for high sensitivity and specificity. The luminol de
Externí odkaz:
https://doaj.org/article/0a9fab2f08ad48e9b3da209f3c6b8be7
Autor:
Robert K. Batori, Feng Chen, Zsuzsanna Bordan, Stephen Haigh, Yunchao Su, Alexander D. Verin, Scott A. Barman, David W. Stepp, Trinad Chakraborty, Rudolf Lucas, David J. R. Fulton
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Pneumolysin (PLY) is a bacterial pore forming toxin and primary virulence factor of Streptococcus pneumonia, a major cause of pneumonia. PLY binds cholesterol-rich domains of the endothelial cell (EC) plasma membrane resulting in pore assembly and in
Externí odkaz:
https://doaj.org/article/a855244bd2ed44449d1488efd66170f2
Autor:
Adeola A. Sanni‐Ajibaye, Anson M. Blanks, Cassandra C. Derella, Abigayle B. Simon, Paula Rodriguez‐Miguelez, Jacob Looney, Jinhee Jeong, Jeffrey Thomas, David W. Stepp, Neal L. Weintraub, Xiaoling Wang, Ryan A. Harris
Publikováno v:
Physiological Reports, Vol 10, Iss 10, Pp n/a-n/a (2022)
Abstract Upregulation of endothelin‐1 (ET‐1) is the hallmark of various cardiovascular diseases (CVD). The purpose of the present study was to assess the ET‐1 response to an acute bout of whole‐body vibration (WBV) in humans and to determine
Externí odkaz:
https://doaj.org/article/6b8d81ce13d746569de7b459d88885a1
Autor:
Caleb A. Padgett, Joshua T. Butcher, Steven B. Haigh, Andrew C. Speese, Zachary L. Corley, Cody L. Rosewater, Hunter G. Sellers, Sebastian Larion, James D. Mintz, David J. R. Fulton, David W. Stepp
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Obese individuals are at significantly elevated risk of developing cardiovascular disease (CVD). Additionally, obesity has been associated with disrupted circadian rhythm, manifesting in abnormal sleeping and feeding patterns. To date, the mechanisms
Externí odkaz:
https://doaj.org/article/5763db3859c64c93ace487613e1abb87
Autor:
Anson M. Blanks, Paula Rodriguez-Miguelez, Jacob Looney, Matthew A. Tucker, Jinhee Jeong, Jeffrey Thomas, Marsha Blackburn, David W. Stepp, Neal J. Weintraub, Ryan A. Harris
Publikováno v:
Brain, Behavior, & Immunity - Health, Vol 1, Iss , Pp 100011- (2020)
Traditional aerobic exercise reduces the risk of developing chronic diseases by inducing immune, metabolic, and myokine responses. Following traditional exercise, both the magnitude and time-course of these beneficial responses are different between
Externí odkaz:
https://doaj.org/article/911460debd724fe4a0fc515d1150c8a3
Autor:
Sebastian Larion, Caleb A. Padgett, Joshua T. Butcher, James D. Mintz, David J. Fulton, David W. Stepp
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 323:G387-G400
Nonalcoholic fatty liver disease (NAFLD) is associated with disruption of homeostatic lipid metabolism, but underlying processes are poorly understood. One possible mechanism is impairment in hepatic circadian rhythm, which regulates key lipogenic me